RECRUITING

Feasibility of Semaglutide in Advanced Lung Disease

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this clinical trial is to learn whether semaglutide, an FDA-approved treatment for diabetes and obesity, is feasible and tolerable in patients with advanced lung disease. The main question\[s\] it aims to answer are: 1. Are patients with advanced lung disease able to tolerate semaglutide therapy? 2. Are we able to titrate semaglutide therapy to a target weight? Participants will be asked to perform pulmonary function, physical function and body composition testing, as well as a blood draw before and after 12-weeks of semaglutide therapy. While on therapy, subjects will be surveyed regarding any adverse events or side effects.

Official Title

Feasibility of Semaglutide Therapy for Weight Loss in Advanced Lung Disease: A Pilot Study

Quick Facts

Study Start:2024-01-29
Study Completion:2024-12-28
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05746039

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 80 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Diagnosis of one of the following lung diseases: interstitial lung disease, sarcoidosis, chronic obstructive pulmonary disease, or pulmonary hypertension
  2. * Age \> 18
  3. * BMI \> 30 kg/m2
  4. * Requires supplemental oxygen on exertion
  5. * Stable treatment regimen X 90 days
  6. * Use of disease-modifying therapy
  1. * Diabetes
  2. * Pregnant or Breastfeeding
  3. * Recent weight loss
  4. * Recent or chronic GI complaints
  5. * History of gastroparesis
  6. * History of scleroderma
  7. * Hospitalized at time of evaluation
  8. * Use of weight loss medication in last 90 days
  9. * Personal or family history of medullary thyroid cancer or multiple endocrine neoplasia (type 2)
  10. * Uncontrolled thyroid disease
  11. * History of acute/chronic pancreatitis
  12. * Prior suicide attempt
  13. * Suicidal ideation in last 90 days
  14. * Presence of a pacemaker or defibrillator

Contacts and Locations

Study Contact

Michaela R Anderson, MD
CONTACT
215-662-3202
michaela.anderson@pennmedicine.upenn.edu

Principal Investigator

Michaela R Anderson, MD
PRINCIPAL_INVESTIGATOR
University of Pennsylvania

Study Locations (Sites)

University of Pennsylvania Perelman School of Medicine
Philadelphia, Pennsylvania, 19104
United States

Collaborators and Investigators

Sponsor: University of Pennsylvania

  • Michaela R Anderson, MD, PRINCIPAL_INVESTIGATOR, University of Pennsylvania

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-01-29
Study Completion Date2024-12-28

Study Record Updates

Study Start Date2024-01-29
Study Completion Date2024-12-28

Terms related to this study

Keywords Provided by Researchers

  • semaglutide

Additional Relevant MeSH Terms

  • Obesity
  • Interstitial Lung Disease
  • Chronic Obstructive Pulmonary Disease
  • Sarcoidosis, Pulmonary
  • Pulmonary Hypertension