Tumor Treating Fields for the Treatment of Leptomeningeal Metastases of the Spine in Patients with Breast Cancer

Eligibility Criteria

• * Age \>= 18
• * Prior tissue diagnosis of breast cancer
• * Confirmed diagnosis of leptomeningeal metastases (LM) with positive cerebrospinal fluid (CSF) cytology for malignancy and meningeal enhancement (type 1A, 1B, and 1C)
• * Radiographic evidence on MRI of leptomeningeal enhancement within the cervical, thoracic or lumbar spine on spinal MRI
• * Life expectancy of at least 6 weeks
• * Eastern Cooperative Oncology Group (ECOG) performance status of 0, 1, 2, or 3
• * Recovery from any neurotoxic effects of prior therapy
• * Platelet count greater than 25 x 10\^9/L
• * Absolute neutrophil count (ANC) greater than 0.5 x 10\^9/L
• * Patients must have adequate liver function, total bilirubin \< 2.5 mg/dL, unless elevated total bilirubin is due to elevated indirect bilirubin from known Gilbert's disease, aspartate aminotransferase (AST) =\< 3.5 times upper limits of normal; adequate renal function \[calculated estimated glomerular filtration rate (eGFR) \>= 30 mL/min/ body surface area (BSA)\]
• * Patients or legal medical representative must provide written informed consent
• * Patients must have suitable body habitus for placement of transducer arrays
• * Patients must be willing to wear the device for at least 18 hours a day (averaged over monthly)
• * Patients must be willing to return for the scheduled evaluations and perform the required assessments
• * Patients are without other disease or situation which would significantly compromise adequate assessment of safety and feasibility of the TTF
• * Patient willing to start a study treatment with TTF =\< 14 days from registration
• * Concomitant therapy:
• * Must not be receiving concurrent high-dose methotrexate (\>= 3 g/m\^2), high dose thiotepa, or high-dose cytarabine (\>= 3 g/m\^2). Any other systemic chemotherapy, targeted treatment, hormonal or immunotherapy directed at the primary systemic malignancy is permitted
• * Must not have received radiation therapy (RT) to the brain or spinal cord within 2 weeks of initiation of TTF
• * Must be at least 1 week from cessation of any prior intrathecal chemotherapy
• * Women of childbearing age who are pregnant or lactating. (Male and female patients who are fertile must be willing to use an effective means of birth control to avoid pregnancy)
• * Patients with uncontrolled or untreated infection including active hepatitis, and human immunodeficiency virus (HIV)
• * Patients receiving any other investigational agents and must not have received any other investigational agent within 14 days prior to registration. The 14-day period should be extended if the investigational agent is known to have delayed toxicity
• * Patients known to be allergic to the hydrophilic gel utilized for transducer attachment
• * Patients with surgical hardware within the planned area of treatment in the spine (e.g., titanium rods, screws, fixation devices)