Exploring the Effects of an Intravaginal Lactic Acid Gel on the Vaginal Microbiome

Description

This project aims to investigate if the contraceptive method, Phexxi, causes changes to the composition of the vaginal microbiome. The investigators hypothesize that regular use of Phexxi will cause increased colonization of lactic acid-producing lactobacilli, which could have positive effects in the way of preventing recurrent episodes of BV and candida infections.

Conditions

Bacterial Vaginosis, Vulvovaginal Candidiasis

Study Overview

Study Details

Study overview

This project aims to investigate if the contraceptive method, Phexxi, causes changes to the composition of the vaginal microbiome. The investigators hypothesize that regular use of Phexxi will cause increased colonization of lactic acid-producing lactobacilli, which could have positive effects in the way of preventing recurrent episodes of BV and candida infections.

Exploring the Effects of an Intravaginal Lactic Acid Gel on the Vaginal Microbiome

Exploring the Effects of an Intravaginal Lactic Acid Gel on the Vaginal Microbiome

Condition
Bacterial Vaginosis
Intervention / Treatment

-

Contacts and Locations

Honolulu

Queens Medical Center, 1004 Clinic POB1, Honolulu, Hawaii, United States, 96813

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age 18-54
  • * Female
  • * Pre-menopausal
  • * Can speak and read in English
  • * Displays capacity for informed consent
  • * Has had 2 or more documented and/or self-reported episodes of symptomatic BV or candida infection in the last year, requiring, over-the-counter or prescription treatment
  • * Pregnant or trying to become pregnant
  • * Post-menopausal
  • * Using NuvaRing device
  • * A past medical history of kidney disease, recurrent UTI, and/or urinary tract abnormalities
  • * Current UTI
  • * Using Phexxi as a contraceptive during the collection period of the study

Ages Eligible for Study

18 Years to 54 Years

Sexes Eligible for Study

FEMALE

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Queen's Medical Center,

Olivia Manayan, MD, MPH, PRINCIPAL_INVESTIGATOR, University of Hawaii

Bliss Kaneshiro, MD, MPH, PRINCIPAL_INVESTIGATOR, Queen's Medical Center

Corrie Miller, DO, PRINCIPAL_INVESTIGATOR, University of Hawaii

Study Record Dates

2025-12-30