Blood Pressure Variability and Ischemic Stroke Outcome

Description

The goal of this observational study is to evaluate the role of blood pressure (BPV) variability in patients suffering from acute ischemic stroke. The main questions it aims to answer are: 1. To determine the association of BPV with functional/cognitive outcome after ischemic stroke. 2. To determine a pathophysiologic mechanism of BPV's deleterious effect on functional outcome. 3. To evaluate potential treatment targets to pharmacologically reduce BPV after ischemic stroke.

Conditions

Acute Ischemic Stroke, Blood Pressure Variability

Study Overview

Study Details

Study overview

The goal of this observational study is to evaluate the role of blood pressure (BPV) variability in patients suffering from acute ischemic stroke. The main questions it aims to answer are: 1. To determine the association of BPV with functional/cognitive outcome after ischemic stroke. 2. To determine a pathophysiologic mechanism of BPV's deleterious effect on functional outcome. 3. To evaluate potential treatment targets to pharmacologically reduce BPV after ischemic stroke.

Blood Pressure Variability and Ischemic Stroke Outcome

Blood Pressure Variability and Ischemic Stroke Outcome

Condition
Acute Ischemic Stroke
Intervention / Treatment

-

Contacts and Locations

New Haven

Yale-New Haven Hospital, New Haven, Connecticut, United States, 06510

Chicago

University of Chicago Medical Center, Chicago, Illinois, United States, 60637

Boston

Massachusetts General Hospital, Boston, Massachusetts, United States, 02114

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Ischemic stroke according to the American Heart Association (AHA) definition and either:
  • 1. CT or MRI showing ischemic stroke in the anterior circulation (frontal, parietal or superior temporal lobes), or
  • 2. Occlusion of the internal carotid, middle cerebral or anterior cerebral arteries on computed tomography angiography (CTA) or magnetic resonance angiography (MRA)
  • * Pre-morbid mRS ≥3
  • * Predicted hospital system admission \<72 hours
  • * Pacemaker or other MRI contraindications per American College of Radiology guidelines

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Yale University,

Adam de Havenon, MD, PRINCIPAL_INVESTIGATOR, Yale University

Study Record Dates

2026-03-30