Neuromodulation and Neuroimaging in Older Children with Mild Traumatic Brain Injury

Description

Mild traumatic brain injury (mTBI) often causes persistent motor and cognitive deficits in children resulting in functional limitations. We are testing a brain stimulation method along with evaluating objective tools to help record and restore communication among affected brain areas, which will facilitate recovery in youth after mTBI.

Conditions

Brain Concussion, Mild Traumatic Brain Injury, Motor Disorders, Cognitive Impairment

Study Overview

Study Details

Study overview

Mild traumatic brain injury (mTBI) often causes persistent motor and cognitive deficits in children resulting in functional limitations. We are testing a brain stimulation method along with evaluating objective tools to help record and restore communication among affected brain areas, which will facilitate recovery in youth after mTBI.

Assessing the Efficacy of Alterations in Subcortical-Cortical Functional Connectivity from Transcranial Direct Current Stimulation in Older Children After Mild Traumatic Brain Injury

Neuromodulation and Neuroimaging in Older Children with Mild Traumatic Brain Injury

Condition
Brain Concussion
Intervention / Treatment

-

Contacts and Locations

Buffalo

Ghazala Saleem, Buffalo, New York, United States, 14214

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * age 10-15 years at enrollment
  • * enrolled after 6 weeks of mTBI injury
  • * exhibiting post-concussive symptoms (e.g., difficulty planning, sequencing, and executing a motor action)
  • * Sustained an mTBI or concussion within the past 12 months
  • * Parent and child proficient in English
  • * loss of consciousness \> 30 minutes
  • * post-traumatic amnesia \> 24 hours
  • * intracranial findings on clinical imaging
  • * history of developmental delay
  • * history of learning disability or ADHD
  • * Sustained a lower limb or upper limb injury that has not healed
  • * History of Seizures
  • * Noticeable skin lesions/burns or any other severe skin problems at the site of the electrodes before the start of the stimulation.
  • * Parent/guardian report metal implants anywhere in the head/ncek/body on the MRI screening form (see attached).
  • * Parent/guardian report shrapnel/bullets in the body on the MRI screening form.
  • * Parent/guardian report any electronic implant such as a cardiac pacemaker, cochlear implant, ventricular shunt, cardiac defibrillator, aneurysm clips, pacing wires, any implant held in place with a magnet, heart valve, or deep brain stimulator on the MRI screening form.
  • * Parent/guardian report a craniotomy or any other surgery in the past 6 weeks on the MRI screening form.
  • * Parent/guardian report being claustrophobic on the MRI screening form.
  • * Parent/guardian report and provide orbit x-ray after the eye injury involving a metal that the subject is cleared as indicated on the MRI screening form.
  • * Pregnant females as reported by parent/guardian on the pre-consent screening form. Pubertal/post-pubertal female participants14 and above will be provided a separate post-consent screening form at each MRI visit to ensure the female reports accurately without fear.

Ages Eligible for Study

10 Years to 15 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

State University of New York at Buffalo,

Ghazala Saleem, EdD, PRINCIPAL_INVESTIGATOR, State University of New York at Buffalo

Study Record Dates

2025-12