Effect of Dapagliflozin on Microvascular Function in Women With Symptoms of Coronary Artery Disease

Description

The goal of this clinical trial is to test the effects of a drug (in the drug class called sodium-glucose cotransporter 2 inhibitors) in women who have symptoms of ischemic heart disease. The main questions the study aims to answer are: Does blood flow in the heart improve with study drug? Participants will be randomly assigned to a 12-week course of the study drug, dapagliflozin 10mg, or placebo. Blood flow in the heart will be assessed using stress cardiac magnetic resonance imaging at baseline and 12 weeks. The researchers will compare the results from the two groups.

Conditions

Myocardial Ischemia

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Study Overview

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Study Details

Study overview

The goal of this clinical trial is to test the effects of a drug (in the drug class called sodium-glucose cotransporter 2 inhibitors) in women who have symptoms of ischemic heart disease. The main questions the study aims to answer are: Does blood flow in the heart improve with study drug? Participants will be randomly assigned to a 12-week course of the study drug, dapagliflozin 10mg, or placebo. Blood flow in the heart will be assessed using stress cardiac magnetic resonance imaging at baseline and 12 weeks. The researchers will compare the results from the two groups.

A Single-center, Randomized, Double-blind, Placebo-controlled Study to Evaluate Microvascular Disease After 12 Weeks of Therapy With Sodium-glucose Co-transporter 2 Inhibitor Compared to Placebo in Symptomatic Women With Non-obstructive Coronary Artery Disease

Effect of Dapagliflozin on Microvascular Function in Women With Symptoms of Coronary Artery Disease

Condition
Myocardial Ischemia
Intervention / Treatment

-

Contacts and Locations

Charlottesville

University of Virginia, Charlottesville, Virginia, United States, 22908

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Willing to provide written informed consent.
  • * Signs and symptoms of suspected ischemia that prompted referral for further evaluation by cardiac catheterization or coronary computed tomography within two years of consent.
  • * No evidence of obstructive epicardial coronary artery disease (stenosis \>50%) of a major epicardial vessel (\>3mm) or a fractional flow reserve \>0.80 by invasive catheterization or coronary computed tomography. (Participants who have not undergone cardiac catheterization or coronary angiogram within the last 2 years for their clinical care will be screened with computed angiogram of the coronary arteries to confirm eligibility).
  • * Estimated glomerular filtration rate ≥30ml/min/1.73m2 at enrollment
  • * For subjects having a history of type 2 diabetes mellitus: approval of diabetes care/prescribing provider
  • * History of non-ischemic cardiomyopathy with left ventricular ejection fraction \<40% or hypertrophic cardiomyopathy.
  • * History of congestive heart failure, severe pulmonary disease, liver disease
  • * History of Acute coronary syndrome within previous 30 days
  • * Stroke within the last 180 days or intracranial hemorrhage at any time.
  • * Severe Valvular disease
  • * Life expectancy \<3 years, due to non-cardiovascular comorbidity.
  • * Pregnancy or women who are breast-feeding
  • * Type 1 diabetes mellitus
  • * History of diabetic ketoacidosis in subjects with Type 2 Diabetes Mellitus
  • * Symptomatic hypotension or systolic blood pressure \<95 mmHg on 2 consecutive measurements
  • * Active malignancy requiring treatment at the time of visit
  • * Severe, unstable, or rapidly progressing renal disease at the time of randomization
  • * History of recurrent urinary tract, bladder, or kidney infections

Ages Eligible for Study

18 Years to 99 Years

Sexes Eligible for Study

FEMALE

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Virginia,

Caroline L Flournoy, MD, PRINCIPAL_INVESTIGATOR, University of Virginia Health System

Study Record Dates

2025-03-31