RECRUITING

Vaping and Smoking Withdrawal Project

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The proposed research, which will systematically and comprehensively characterize the withdrawal among daily vapers compared to daily smokers of combustible cigarettes, filling critical gaps in the understanding of electronic nicotine delivery systems (ENDS) dependence/abuse liability and contributing to the development of therapies for tobacco/nicotine use, the leading preventable cause of death in the US.

Official Title

A Controlled Evaluation of Abstinence-Induced Withdrawal and Motivation to Vape/Smoke Among Daily ENDS Users vs. Cigarette Smokers

Quick Facts

Study Start:2023-02-14
Study Completion:2026-11-30
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05772845

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:21 Years to 50 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. * 6+ months of daily/near-daily nicotine vaping and/or cigarette smoking (to yield 160 vapers, 160 smokers, 50 dual users)
  2. * 200+ ng/mL cotinine on a commercially-available quick screen
  1. * intention to quit daily/near-daily vaping/smoking in the next month
  2. * current (2+ days out of the past 7) use of pipe tobacco, hookah/shisha, smokeless tobacco, dissolvable tobacco, nicotine pouches. For vaping group only, current (2+ days out of past 7) use of cigars, cigarillos, or filtered cigars that are filled with tobacco or a mix of tobacco and marijuana
  3. * current use of any smoking cessation medication
  4. * current severe substance dependence other than tobacco/nicotine (including cannabis; NIDA Modified ASSIST of 27+)
  5. * current (past 2 weeks) suicidal ideation with intent and/or plan
  6. * current antipsychotic medications or lifetime history of schizophrenia or bipolar disorder
  7. * pregnancy (intake urine screen)
  8. * \>1 use in past month of tobacco/nicotine products other than ENDS and combustible cigarettes (modified 5/19/25 - see current exclusion criteria)
  9. * alcohol: AUDIT \> 15 for males and \>13 for females (eliminated 7/25/23)
  10. * current major depression (PHQ-9\>11) (eliminated 7/25/23)
  11. * suicide risk (answer to question #9 on PHQ-9 is anything other than "Not at all") (modified 11/17/23 - see current exclusion criteria)

Contacts and Locations

Study Contact

Larry Hawk, PhD
CONTACT
716-645-0192
lhawk@buffalo.edu

Principal Investigator

Larry Hawk, PhD
PRINCIPAL_INVESTIGATOR
University at Buffalo

Study Locations (Sites)

University at Buffalo
Buffalo, New York, 14260
United States

Collaborators and Investigators

Sponsor: State University of New York at Buffalo

  • Larry Hawk, PhD, PRINCIPAL_INVESTIGATOR, University at Buffalo

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-02-14
Study Completion Date2026-11-30

Study Record Updates

Study Start Date2023-02-14
Study Completion Date2026-11-30

Terms related to this study

Additional Relevant MeSH Terms

  • Acute Abstinence From Cigarettes vs E-cigarettes (ENDS)