Vaping and Smoking Withdrawal Project

Description

The proposed research, which will systematically and comprehensively characterize the withdrawal among daily vapers compared to daily smokers of combustible cigarettes, filling critical gaps in the understanding of electronic nicotine delivery systems (ENDS) dependence/abuse liability and contributing to the development of therapies for tobacco/nicotine use, the leading preventable cause of death in the US.

Conditions

Acute Abstinence From Cigarettes vs E-cigarettes (ENDS)

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Study Overview

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Study Details

Study overview

The proposed research, which will systematically and comprehensively characterize the withdrawal among daily vapers compared to daily smokers of combustible cigarettes, filling critical gaps in the understanding of electronic nicotine delivery systems (ENDS) dependence/abuse liability and contributing to the development of therapies for tobacco/nicotine use, the leading preventable cause of death in the US.

A Controlled Evaluation of Abstinence-Induced Withdrawal and Motivation to Vape/Smoke Among Daily ENDS Users vs. Cigarette Smokers

Vaping and Smoking Withdrawal Project

Condition
Acute Abstinence From Cigarettes vs E-cigarettes (ENDS)
Intervention / Treatment

-

Contacts and Locations

Buffalo

University at Buffalo, Buffalo, New York, United States, 14260

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * 6+ months of daily/near-daily nicotine vaping and/or cigarette smoking (to yield 160 vapers, 160 smokers, 50 dual users)
  • * 200+ ng/mL cotinine on a commercially-available quick screen
  • * intention to quit daily/near-daily vaping/smoking in the next month
  • * current (2+ days out of the past 7) use of pipe tobacco, hookah/shisha, smokeless tobacco, dissolvable tobacco, nicotine pouches. For vaping group only, current (2+ days out of past 7) use of cigars, cigarillos, or filtered cigars that are filled with tobacco or a mix of tobacco and marijuana
  • * current use of any smoking cessation medication
  • * current severe substance dependence other than tobacco/nicotine (including cannabis; NIDA Modified ASSIST of 27+)
  • * current (past 2 weeks) suicidal ideation with intent and/or plan
  • * current antipsychotic medications or lifetime history of schizophrenia or bipolar disorder
  • * pregnancy (intake urine screen)
  • * \>1 use in past month of tobacco/nicotine products other than ENDS and combustible cigarettes (modified 5/19/25 - see current exclusion criteria)
  • * alcohol: AUDIT \> 15 for males and \>13 for females (eliminated 7/25/23)
  • * current major depression (PHQ-9\>11) (eliminated 7/25/23)
  • * suicide risk (answer to question #9 on PHQ-9 is anything other than "Not at all") (modified 11/17/23 - see current exclusion criteria)

Ages Eligible for Study

21 Years to 50 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

State University of New York at Buffalo,

Larry Hawk, PhD, PRINCIPAL_INVESTIGATOR, University at Buffalo

Study Record Dates

2026-11-30