RECRUITING

PET/CT Imaging to Evaluate Cardiac Radiation Damage in Patients With Lung or Esophageal Cancer, EUCLID Trial

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This clinical trial examines positron emission tomography (PET)/computed tomography (CT) in evaluating cardiac radiation damage in patients with lung or esophageal cancer. As part of the treatment for lung or esophageal cancer, patients will undergo radiation therapy. Sometimes, during this treatment, the heart is also subjected to some radiation which could affect its function, either increasing or decreasing the function. It is not known the consequences of this change nor is it known if doctors can detect the changes associated with the radiation. Sarcoidosis FDG positron emission tomography (PET)-computed tomography (CT) scans are a common way to image cardiac inflammation and myocardial viability. This study may help doctors image the heart before, during and after radiotherapy to monitor any changes.

Official Title

PET Functional Imaging to Evaluate Cardiac Radiation Damage (EUCLID)

Quick Facts

Study Start:2023-01-20
Study Completion:2026-01-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05775939

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Provide signed and dated informed consent form
  2. * Willing to comply with all study procedures and be available for the duration of the study
  3. * Male or female, aged \>= 18
  4. * Life expectancy \>= 3 months as assessed by Radiation Oncologist
  5. * Mean heart dose estimated by Radiation Oncologist to be \>= 5 Gy (physics dose or biologically equivalent dose)
  6. * Pathologically proven (either histologic or cytologic) proven lung cancer or esophageal cancer
  7. * Planned radiation treatment course for management of lung or esophageal cancer \* Both standard and hypofractionation schedules are permitted
  1. * Contraindication for FDG PET-CT scans as assessed by the radiation oncologist or nuclear medicine radiologist
  2. * Palliative radiation doses defined as 20 Gy in 5 fractions

Contacts and Locations

Study Contact

Yevgeniy Vinogradskiy, MD
CONTACT
215-955-3605
yevgeniy.vinogradskiy@jefferson.edu

Principal Investigator

Yevgeniy Vinogradskiy
PRINCIPAL_INVESTIGATOR
Thomas Jefferson University

Study Locations (Sites)

Thomas Jefferson University Hospital
Philadelphia, Pennsylvania, 19107
United States

Collaborators and Investigators

Sponsor: Thomas Jefferson University

  • Yevgeniy Vinogradskiy, PRINCIPAL_INVESTIGATOR, Thomas Jefferson University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-01-20
Study Completion Date2026-01-01

Study Record Updates

Study Start Date2023-01-20
Study Completion Date2026-01-01

Terms related to this study

Additional Relevant MeSH Terms

  • Lung Carcinoma
  • Esophageal Carcinoma