The Effects of Two Exercise Interventions on Breast Cancer Patients Undergoing Cardiotoxic Chemotherapies

Description

The purpose of this study is to determine if exercise preconditioning can mitigate the off target effects of chemotherapy treatment on measures of cardiovascular function, inflammatory responses, and quality of life.

Conditions

Breast Cancer, Cardiotoxicity, Cardiovascular Diseases

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Study Overview

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Study Details

Study overview

The purpose of this study is to determine if exercise preconditioning can mitigate the off target effects of chemotherapy treatment on measures of cardiovascular function, inflammatory responses, and quality of life.

A Feasibility Study to Examine Two Remotely-monitored Exercise Interventions on Breast Cancer Patients Undergoing Cardiotoxic Chemotherapies

The Effects of Two Exercise Interventions on Breast Cancer Patients Undergoing Cardiotoxic Chemotherapies

Condition
Breast Cancer
Intervention / Treatment

-

Contacts and Locations

Charlottesville

University of Virginia University Hospital, Charlottesville, Virginia, United States, 22903

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age 18 years or over
  • * diagnosis of breast cancer (Stage I-III or IV with minimal burden) and prescribed chemotherapy (TC (Docetaxel/Cyclophosphamide), AC (Doxorubicin/Cyclophosphamide followed by Paclitaxel), TCHP (Docetaxel, Carboplatin, Trastuzumab, Pertuzumab), TCH (Docetaxel/Carboplatin/Trastuzumab) with or without Pembrolizumab)
  • * Physician clearance for exercise training
  • * Speak/understand English
  • * previous treatment with cardiotoxic chemotherapy
  • * medical/orthopedic comorbidities that preclude stationary cycling
  • * significant cardiac/renal/hepatic/hematological/pulmonary disease precluding exercise training
  • * unstable angina or myocardial infarction within 4-weeks prior to treatment
  • * complex ventricular arrhythmias or New York Heart Association class IV symptoms
  • * symptomatic severe aortic stenosis
  • * acute pulmonary embolus
  • * acute myocarditis
  • * History of untreated high-risk proliferative retinopathy
  • * History of retinal hemorrhage
  • * uncontrolled hypertension (systolic blood pressure \> 180 mm Hg or diastolic blood pressure \> 120 mm Hg)
  • * severe baseline electrolyte abnormalities
  • * medication non-compliance
  • * uncontrolled metabolic disease (diabetes with fasting blood sugar \>300 mg/dl, thyrotoxicosis, myxedema)
  • * symptomatic peripheral vascular disease
  • * Pregnant women

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

FEMALE

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Virginia,

Study Record Dates

2025-03-15