Effects of Aerobic Exercise on Skeletal Muscle Remodeling in Colorectal Cancer

Description

The goal of this clinical trial is to quantify the effects of aerobic exercise training compared to attention control on intermuscular adipose tissue in colorectal cancer survivors.

Conditions

Colonic Neoplasms, Rectal Neoplasms

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Study Overview

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Study Details

Study overview

The goal of this clinical trial is to quantify the effects of aerobic exercise training compared to attention control on intermuscular adipose tissue in colorectal cancer survivors.

Effects of Aerobic Exercise on Skeletal Muscle Remodeling in Colorectal Cancer

Effects of Aerobic Exercise on Skeletal Muscle Remodeling in Colorectal Cancer

Condition
Colonic Neoplasms
Intervention / Treatment

-

Contacts and Locations

Baton Rouge

Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States, 70808

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age ≥18 years
  • * Histologically confirmed stage I, II, or III colon or rectal cancer
  • * Completed surgical resection with curative intent
  • * Completed other cancer-directed treatments
  • * Engage in \<150 minutes per week of moderate- to vigorous-intensity structured endurance exercise
  • * No planned major surgery during the study period
  • * Readiness to exercise, as determined by a modified version of the Physical Activity Readiness Questionnaire
  • * Ability to provide written informed consent
  • * Provide written approval by a qualified healthcare professional
  • * Willing to be randomized
  • * Evidence of metastatic or recurrent colorectal cancer
  • * Concurrently actively treated other (non-colorectal) cancer
  • * Scheduled to receive other postoperative cancer-directed treatment(s)
  • * Currently pregnant, breastfeeding, or planning to become pregnant within the next 24 weeks
  • * Currently participating in another study with competing outcomes
  • * Contraindications to magnetic resonance imaging
  • * Any dietary condition or restriction that would limit tolerance of a mixed meal challenge
  • * Any other cardiovascular, pulmonary, orthopedic, neurologic, psychiatric, or other condition that, in the investigator's opinion, would preclude participation or successful compliance with the protocol
  • * Any other situation that, in the opinion of the investigator, would negatively impact subject safety or successful compliance with the protocol

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Pennington Biomedical Research Center,

Justin C. Brown, Ph.D., PRINCIPAL_INVESTIGATOR, Pennington Biomedical Research Center

Study Record Dates

2027-03