A Study on the Effects of Exercise on Side Effects From Treatment for Gastrointestinal Cancers

Description

The purpose of this study is to find the level of aerobic exercise (AT) that is practical, is safe, and has positive effects on the body that may reduce the side effects of therapy. The study will also look at the way the body responds to exercise and whether there are differences in treatment. This will include looking at the highest treatment dose participants receive, how many people stop, delay, or reduce the treatment, and whether additional medication is needed to treat side effects of therapy.

Conditions

Gastrointestinal Cancer

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Study Overview

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Study Details

Study overview

The purpose of this study is to find the level of aerobic exercise (AT) that is practical, is safe, and has positive effects on the body that may reduce the side effects of therapy. The study will also look at the way the body responds to exercise and whether there are differences in treatment. This will include looking at the highest treatment dose participants receive, how many people stop, delay, or reduce the treatment, and whether additional medication is needed to treat side effects of therapy.

Dose-response of Aerobic Training During Neoadjuvant Chemotherapy for Gastrointestinal Cancers

A Study on the Effects of Exercise on Side Effects From Treatment for Gastrointestinal Cancers

Condition
Gastrointestinal Cancer
Intervention / Treatment

-

Contacts and Locations

Hartford

Hartford Healthcare Alliance (Data Collection Only), Hartford, Connecticut, United States, 06102

Basking Ridge

Memorial Sloan Kettering Basking Ridge (Limited Protocol Activities), Basking Ridge, New Jersey, United States, 07920

Middletown

Memorial Sloan Kettering Monmouth (Limited Protocol Activities), Middletown, New Jersey, United States, 07748

Montvale

Memorial Sloan Kettering Bergen (Limited Protocol Activities), Montvale, New Jersey, United States, 07645

Commack

Memorial Sloan Kettering Suffolk - Commack (Limited Protocol Activities), Commack, New York, United States, 11725

Harrison

Memorial Sloan Kettering Westchester (Limited Protocol Activities), Harrison, New York, United States, 10604

New York

Memorial Sloan Kettering Cancer Center (All Protocol Activities), New York, New York, United States, 10065

Rockville Centre

Memorial Sloan Kettering Nassau (Limited Protocol Activities), Rockville Centre, New York, United States, 11553

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Aged ≥18 years
  • * Diagnosed with locally advanced colorectal or esophago/gastric solid tumors as defined by one of the following:
  • * Histological confirmation
  • * As per standard of care imaging
  • * Scheduled to receive neoadjuvant chemotherapy
  • * Performing ≤90 minutes of structured moderate-intensity or strenuous-intensity exercise per week, as evaluated by self-report
  • * Willingness to comply with all study-related procedures
  • * Cleared for exercise participation as per screening clearance via the Physical Activity Readiness Questionnaire
  • * Enrollment onto any other interventional investigational study, except interventions determined by the PI not to confound study outcomes
  • * Receiving treatment for any other diagnosis of invasive cancer
  • * Distant metastatic malignancy of any kind
  • * Mental impairment leading to inability to cooperate
  • * Any other condition or intercurrent illness that, in the opinion of the investigator, makes the subject a poor candidate for study participation

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Memorial Sloan Kettering Cancer Center,

Jessica Scott, PhD, PRINCIPAL_INVESTIGATOR, Memorial Sloan Kettering Cancer Center

Study Record Dates

2027-04-18