RECRUITING

Motivational Refinements for Facilitating Reinforcement Schedule Thinning

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Destructive behavior represents a comorbid condition of developmental disability for which risk increases with intellectual disability severity, communication deficits, and co-occurring autism spectrum disorder. Destructive behavior, such as self-injurious behavior and aggression, causes harm to the child and others and increases the risk for institutionalization, social isolation, physical restraint, medication overuse, and abuse. Clinicians have used functional analyses to identify the variables that reinforce destructive behavior and to develop effective, function-based treatments. Functional communication training (FCT) is an empirically supported, function-based treatment that decreases destructive behavior. Using FCT, the clinician teaches the child to use a functional communication response (FCR) to request the reinforcer maintaining destructive behavior, while placing destructive behavior on extinction. For example, if functional analysis results showed that attention reinforced destructive behavior, the clinician would provide attention when the child used the FCR ("Play with me, please") and would not provide attention for destructive behavior. Two limitations of FCT are that (a) schedules of reinforcement maintaining the FCR must often be thinned gradually to levels that are practical for caregivers to implement consistently in the home and in the community, and (b) this necessary process of reinforcement schedule thinning regularly causes destructive behavior to increase following initially effective treatment, a form of treatment relapse called resurgence. The current project aims to improve these limitations of FCT by (a) hastening the process of reinforcement schedule thinning by removing unnecessary schedule-thinning steps using the results of a progressive interval assessment and (b) mitigating the resurgence of destructive behavior by providing stimuli that highly compete with the reinforcer maintaining destructive behavior. The investigators will conduct a randomized clinical trial to evaluate the extent to which these two promising refinements to FCT improve the process of reinforcement schedule thinning, and an exploratory experiment will examine the interactive effects of these two approaches. This novel project has the potential to substantially improve standards of care guiding the treatment of severe destructive behavior and to improve the long-term outcomes for children and families afflicted by these debilitating behavior disorders.

Official Title

Motivational Refinements for Facilitating Reinforcement Schedule Thinning

Quick Facts

Study Start:2023-10-24
Study Completion:2028-08-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05790668

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:3 Years to 17 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:CHILD
Inclusion CriteriaExclusion Criteria
  1. * boys and girls from ages 3 to 17
  2. * destructive behavior that occurs at least 10 times a day, despite previous treatment
  3. * destructive behavior reinforced by social consequences
  4. * stable protective supports for self-injurious behavior (e.g., helmet) with no anticipated changes during enrollment
  5. * on a stable psychoactive drug regimen for at least 10 half-lives per drug or drug free
  6. * stable educational plan and placement with no anticipated changes during the child's treatment
  1. * patients who do not meet the inclusion criteria
  2. * patients currently receiving 15 or more hours per week of treatment for their destructive behavior
  3. * Diagnostic and Statistical Manual-5 diagnosis of Rett syndrome or other degenerative conditions (e.g., inborn error of metabolism)
  4. * a comorbid health condition or major mental disorder that would interfere with study participation
  5. * occurrence of self-injury during study assessments that presents a risk of serious or permanent harm (e.g., detached retinas) based on routine clinical-risk assessment
  6. * patients requiring changes to protective supports for self-injury or drug treatment, but investigators will invite these patients to participate when protective supports and drug regimen are stable

Contacts and Locations

Study Contact

Brian D Greer, Ph.D.
CONTACT
8488008505
brian.greer@rutgers.edu
Daniel R Mitteer, Ph.D.
CONTACT
8488008506
daniel.mitteer@rutgers.edu

Principal Investigator

Brian D Greer, Ph.D.
PRINCIPAL_INVESTIGATOR
Rutgers, The State University of New Jersey

Study Locations (Sites)

Douglass Developmental Disabilities Center
New Brunswick, New Jersey, 08901
United States
Rutgers University Center for Autism Research, Education, and Services
Somerset, New Jersey, 08873
United States

Collaborators and Investigators

Sponsor: Rutgers, The State University of New Jersey

  • Brian D Greer, Ph.D., PRINCIPAL_INVESTIGATOR, Rutgers, The State University of New Jersey

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-10-24
Study Completion Date2028-08-31

Study Record Updates

Study Start Date2023-10-24
Study Completion Date2028-08-31

Terms related to this study

Keywords Provided by Researchers

  • functional communication training
  • reinforcement schedule thinning
  • resurgence
  • treatment relapse

Additional Relevant MeSH Terms

  • Decreasing Destructive Behavior
  • Increasing Functional Communicative Behavior