The Role of Macrophage Activation in Lung Injury Following Ozone Exposure

Description

The purpose of the study is to better understand the mechanisms of lung injury from ozone exposure. Subjects will participate in two exposure sessions: filtered air and 0.2 ppm ozone. The exposure visits will be at least 2 weeks apart. Subjects will be asked to produce sputum through coughing after each exposure. The samples will be analyzed for macrophage activity.

Conditions

Air Pollution

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Study Overview

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Study Details

Study overview

The purpose of the study is to better understand the mechanisms of lung injury from ozone exposure. Subjects will participate in two exposure sessions: filtered air and 0.2 ppm ozone. The exposure visits will be at least 2 weeks apart. Subjects will be asked to produce sputum through coughing after each exposure. The samples will be analyzed for macrophage activity.

Activated Macrophages and Ozone Toxicity II

The Role of Macrophage Activation in Lung Injury Following Ozone Exposure

Condition
Air Pollution
Intervention / Treatment

-

Contacts and Locations

Piscataway

Rutgers - EOHSI, Piscataway, New Jersey, United States, 08854

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Vaccinated against COVID-19
  • * Cardiovascular disease
  • * Respiratory disease
  • * Recent (within 4 weeks) respiratory or COVID-19 symptoms
  • * Diabetes
  • * Pregnancy
  • * HIV Infection
  • * History of smoking within the past 5 years.
  • * Orthopedic or rheumatologic conditions which would interfere with cycle use
  • * Inability to produce a sputum plug at screening
  • * Daily use of antioxidant supplements, excluding those in a multivitamin. These supplements include Vitamin C or E, selenium, beta-carotene, lycopene, lutein, zeaxanthin and ginkgo biloba. Supplements taken less frequently but at least once a week will be reviewed by the principal investigator for eligibility determination.

Ages Eligible for Study

18 Years to 40 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Rutgers, The State University of New Jersey,

Howard M Kipen, MD, PRINCIPAL_INVESTIGATOR, Rutgers School of Public Health

Study Record Dates

2027-06-01