RECRUITING

The Role of Macrophage Activation in Lung Injury Following Ozone Exposure

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of the study is to better understand the mechanisms of lung injury from ozone exposure. Subjects will participate in two exposure sessions: filtered air and 0.2 ppm ozone. The exposure visits will be at least 2 weeks apart. Subjects will be asked to produce sputum through coughing after each exposure. The samples will be analyzed for macrophage activity.

Official Title

Activated Macrophages and Ozone Toxicity II

Quick Facts

Study Start:2023-02-07
Study Completion:2027-06-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05794087

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 40 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. * Vaccinated against COVID-19
  1. * Cardiovascular disease
  2. * Respiratory disease
  3. * Recent (within 4 weeks) respiratory or COVID-19 symptoms
  4. * Diabetes
  5. * Pregnancy
  6. * HIV Infection
  7. * History of smoking within the past 5 years.
  8. * Orthopedic or rheumatologic conditions which would interfere with cycle use
  9. * Inability to produce a sputum plug at screening
  10. * Daily use of antioxidant supplements, excluding those in a multivitamin. These supplements include Vitamin C or E, selenium, beta-carotene, lycopene, lutein, zeaxanthin and ginkgo biloba. Supplements taken less frequently but at least once a week will be reviewed by the principal investigator for eligibility determination.

Contacts and Locations

Study Contact

Kathleen Black, PhD
CONTACT
8484456049
kgblack@eohsi.rutgers.edu
Adriana De Resende
CONTACT
848-445-0178
ad998@eohsi.rutgers.edu

Principal Investigator

Howard M Kipen, MD
PRINCIPAL_INVESTIGATOR
Rutgers School of Public Health

Study Locations (Sites)

Rutgers - EOHSI
Piscataway, New Jersey, 08854
United States

Collaborators and Investigators

Sponsor: Rutgers, The State University of New Jersey

  • Howard M Kipen, MD, PRINCIPAL_INVESTIGATOR, Rutgers School of Public Health

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-02-07
Study Completion Date2027-06-01

Study Record Updates

Study Start Date2023-02-07
Study Completion Date2027-06-01

Terms related to this study

Keywords Provided by Researchers

  • Macrophage

Additional Relevant MeSH Terms

  • Air Pollution