Replacing Invasive Cystoscopy With Urine Testing for Non-muscle Invasive Bladder Cancer Surveillance

Description

The purpose of this research is to determine whether bladder cancer monitoring can be improved by replacing some cystoscopy procedures with urine testing. Specifically, this study examines whether there are any differences in urinary symptoms, discomfort, number of invasive procedures, anxiety, complications, cancer recurrence or cancer progression when some cystoscopy procedures are replaced with urine testing.

Conditions

Non-muscle-invasive Bladder Cancer

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Study Overview

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Study Details

Study overview

The purpose of this research is to determine whether bladder cancer monitoring can be improved by replacing some cystoscopy procedures with urine testing. Specifically, this study examines whether there are any differences in urinary symptoms, discomfort, number of invasive procedures, anxiety, complications, cancer recurrence or cancer progression when some cystoscopy procedures are replaced with urine testing.

Replacing Invasive Cystoscopy With Urine Testing for Non-muscle Invasive Bladder Cancer Surveillance

Replacing Invasive Cystoscopy With Urine Testing for Non-muscle Invasive Bladder Cancer Surveillance

Condition
Non-muscle-invasive Bladder Cancer
Intervention / Treatment

-

Contacts and Locations

Charleston

Medical University of South Carolina, Charleston, South Carolina, United States, 29425

Dallas

UT Southwestern Medical Center, Dallas, Texas, United States, 75235

White River Junction

White River Junction Veterans Healthcare System, White River Junction, Vermont, United States, 05009

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Aged 18 years or older
  • 2. History of low grade intermediate-risk non-muscle invasive bladder cancer, defined as most recent pathology report showing any of the following:
  • * multifocal low grade non-invasive urothelial carcinoma of any size
  • * solitary low grade non-invasive urothelial carcinoma greater than 3cm in size
  • * recurrent low grade non-invasive urothelial carcinoma
  • 3. Stated willingness to comply with all study procedures and availability for the duration of the study
  • 4. No evidence for recurrence at cystoscopy ≤4 months after most recent tumor resection
  • 5. Ability to consent in English or Spanish
  • 1. History of total cystectomy of the bladder.
  • 2. History of urinary diversion (e.g., neo-bladder, colon pouch, or ileal conduit).
  • 3. History of muscle-invasive bladder tumor.
  • 4. Pregnancy or lactation.
  • 5. History of urothelial carcinoma of the ureter or renal pelvis status post endoscopic treatment or with evidence of recurrent upper tract disease (inclusion allowed if status post nephroureterectomy and recurrence free at time of inclusion)
  • 6. Anatomic constraints making cystoscopy impossible (e.g., history of urethrectomy, obliterated urethra secondary to stricture).
  • 7. Inability to provide a voided urine sample.

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

White River Junction Veterans Affairs Medical Center,

Florian R Schroeck, MD, MS, PRINCIPAL_INVESTIGATOR, White River Junction VA Healthcare System

Study Record Dates

2028-12-30