COMPLETED

Optimizing CAB-LA as PrEP for Women Who Inject Drugs

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this study is to elicit information crucial for designing strategies to support engagement in cabotegravir, a long-acting injectable form of pre-exposure prophylaxis (PrEP) to reduce HIV risk among women who inject drugs (WWID), a population with high unmet need that has been understudied in all phases of PrEP research. The main questions this study aims to answer are: 1. How do WWID perceive long-acting injectable cabotegravir (CAB-LA) as a HIV prevention tool? 2. If and how their decisions to initiate CAB-LA as PrEP are informed by their experiences with other long-acting medications, experience with daily oral medications, and their personal circumstance (e.g., like housing or addition severity)? 3. Do PrEP outcomes (e.g., adherence) and engagement in care over time differ between WWID prescribed CAB-LA versus daily oral PrEP? The sample for this study will be derived from and ongoing prospective trial of "TIARAS," a multi-component behavioral intervention designed to reduce HIV acquisition risk among women who inject drugs (see NCT05192434).

Official Title

Exploring Engagement and Opportunities to Optimize CAB-LA as Pre-exposure Prophylaxis (PrEP) for Women Who Inject Drugs

Quick Facts

Study Start:2022-01-13
Study Completion:2025-07-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:COMPLETED

Study ID

NCT05799339

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:FEMALE
Accepts Healthy Volunteers:No
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * HIV-negative cisgender female
  2. * age ≥ 18 years
  3. * speaks/reads English
  4. * reporting past 6 months day non-prescription injection drug use
  5. * enrolled in the TIARAS trial (NCT05192434)
  1. Pregnancy or breastfeeding
  2. Severe psychiatric disorders
  3. Active substance abuse
  4. Unstable medical conditions
  5. Inability to comply with study requirements

Contacts and Locations

Principal Investigator

Alexis M Roth, PhD, MPH
PRINCIPAL_INVESTIGATOR
Drexel University

Study Locations (Sites)

Prevention Point Philadelphia
Philadelphia, Pennsylvania, 19143
United States

Collaborators and Investigators

Sponsor: Alexis Roth

  • Alexis M Roth, PhD, MPH, PRINCIPAL_INVESTIGATOR, Drexel University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2022-01-13
Study Completion Date2025-07-31

Study Record Updates

Study Start Date2022-01-13
Study Completion Date2025-07-31

Terms related to this study

Keywords Provided by Researchers

  • PrEP
  • Preexposure Prophylaxis
  • WWID
  • Women who inject drugs
  • CAB-LA
  • Long-acting injectable cabotegravir

Additional Relevant MeSH Terms

  • HIV Infections
  • Opioid Use
  • Trauma, Psychological