RECRUITING

Pembrolizumab vs. Observation in People With Triple-negative Breast Cancer Who Had a Pathologic Complete Response After Chemotherapy Plus Pembrolizumab

Conditions

Anatomic Stage I Breast Cancer AJCC v8 Anatomic Stage II Breast Cancer AJCC v8 Anatomic Stage III Breast Cancer AJCC v8 Early Stage Triple-Negative Breast Carcinoma

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The phase III trial compares the effect of pembrolizumab to observation for the treatment of patients with early-stage triple-negative breast cancer who achieved a pathologic complete response after preoperative chemotherapy in combination with pembrolizumab. Immunotherapy with monoclonal antibodies, such as pembrolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. This trial may help researchers determine if observation will result in the same risk of cancer coming back as pembrolizumab after surgery in triple-negative breast cancer patients who achieve pathologic complete response after preoperative chemotherapy with pembrolizumab.

Official Title

OptimICE-PCR: De-Escalation of Therapy in Early-Stage TNBC Patients Who Achieve pCR After Neoadjuvant Chemotherapy With Checkpoint Inhibitor Therapy

Quick Facts

Study Start:2023-06-14

Study Completion:2033-05-31

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:RECRUITING

Study ID

NCT05812807

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:No

Standard Ages:ADULT, OLDER_ADULT

Inclusion Criteria	Exclusion Criteria
* Age \>= 18 years * Eastern Cooperative Oncology Group (ECOG) Performance Status 0-2 * Triple Negative Breast Cancer: * Patients with a history of stage T1cN1-2 or T2-4N0-2 breast cancer according to the primary tumor-regional lymph node anatomic staging criteria of the American Joint Committee on Cancer (AJCC), 8th edition as determined by the investigator in radiologic assessment, clinical assessment or both * Patients must have no residual invasive disease in the breast or lymph nodes after the completion of neoadjuvant therapy. Residual ductal carcinoma in situ (DCIS) is allowed. Isolated tumor cells are considered node-negative * Estrogen (ER) and progesterone (PR) =\< 10%; HER2-negative by American Society of Clinical Oncology (ASCO)/College of American Pathologists (CAP) guidelines (immunohistochemistry \[IHC\] and fluorescence in situ hybridization \[FISH\]) * If invasive disease was present in both breasts, participation in the study is permitted as long as the eligibility criteria are met for both tumors/breasts * Patients must have received neoadjuvant chemotherapy in combination with pembrolizumab for a minimum of 6 cycles. All systemic chemotherapy and ICI therapy should have been completed preoperatively * An interval of no more than 12 weeks between the completion date of the final surgery and the date of randomization * Use of investigational anti-cancer agents must be discontinued at time of registration * Adequate excision: Surgical removal of all clinically evident disease in the breast and lymph nodes as follows: * Breast surgery: Total mastectomy or breast-conserving surgery with histologically negative margins, including no ink on tumor for DCIS, at the time of excision * Lymph node surgery: * For a patient with clinically N0 disease, a sentinel lymph node biopsy should have been performed at time of surgical evaluation, and if pathologically node positive, the patient is no longer eligible. Isolated tumor cells are considered node-negative * For a patient with clinically N1 disease at diagnosis (with positive results from a fine-needle aspiration, core biopsy, or sentinel node biopsy performed prior to preoperative therapy) additional surgical evaluation of the axilla following preoperative therapy is required * If sentinel node biopsy performed before preoperative therapy was negative, no additional surgical evaluation of the axilla is required after preoperative therapy. If sentinel node biopsy performed before preoperative therapy was positive, an ALND is required after preoperative therapy * If the only sentinel node identified by isotope scan is in the internal mammary chain, surgical evaluation of the axilla is still required * If sentinel node evaluation after preoperative therapy is negative, no further additional surgical evaluation of the axilla is required * Axillary dissection without sentinel node evaluation is permitted as the initial or sole axillary evaluation after preoperative therapy * If breast-conserving surgery was performed but patient will not be receiving breast radiation, the patient is not eligible * Not pregnant and not nursing, because this study involves an agent whose genotoxic, mutagenic and teratogenic effects on the developing fetus and newborn are unknown. Therefore, for women of childbearing potential only, a negative serum or urine pregnancy test done =\< 7 days prior to randomization is required * Absolute neutrophil count (ANC) \>= 1,000/mm\^3 * Platelet Count \>= 100,000/mm\^3 * Estimated glomerular filtration rate (eGFR) \>= 15 mL/min/1.73m\^2 * Total Bilirubin =\<1.5 x upper limit of normal (ULN) * Aspartate aminotransferase (AST) serum aspartate aminotransferase \[SGOT\] / alanine aminotransferase (ALT) serum glutamic pyruvic transaminase \[SGPT\] =\< 3 x institutional ULN * Patients must be willing to provide tumor tissue from the diagnostic core biopsy. If inadequate tumor tissue is available, patients are still eligible to participate in the trial * Patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial * Patients with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, should have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification. To be eligible for this trial, patients should be class 2B or better * Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months prior to registration are eligible for this trial	* No stage IV (metastatic) breast cancer * No history of any prior (ipsi- or contralateral) invasive breast cancer. Prior DCIS is allowed * No evidence of recurrent disease following preoperative therapy and surgery * No known active liver disease, e.g. due to hepatitis B virus (HBV), hepatitis C virus (HCV), autoimmune hepatic disorders, or sclerosing cholangitis * No history of intolerance, including Grade 3 or 4 infusion reaction or hypersensitivity to pembrolizumab or murine proteins or any components of the product * No medical conditions that require chronic systemic steroids (\>10 mg prednisone daily or equivalent) or any other form of immunosuppressive medications and has required such therapy in the last two years. Replacement therapy (e.g. thyroxine, insulin, or physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency, etc.) is not considered a form of systemic therapy * Patients who are unable or unwilling to comply with the requirements of the protocol per investigator assessment are not eligible

Inclusion Criteria

Exclusion Criteria

* Age \>= 18 years
* Eastern Cooperative Oncology Group (ECOG) Performance Status 0-2
* Triple Negative Breast Cancer:
* Patients with a history of stage T1cN1-2 or T2-4N0-2 breast cancer according to the primary tumor-regional lymph node anatomic staging criteria of the American Joint Committee on Cancer (AJCC), 8th edition as determined by the investigator in radiologic assessment, clinical assessment or both
* Patients must have no residual invasive disease in the breast or lymph nodes after the completion of neoadjuvant therapy. Residual ductal carcinoma in situ (DCIS) is allowed. Isolated tumor cells are considered node-negative
* Estrogen (ER) and progesterone (PR) =\< 10%; HER2-negative by American Society of Clinical Oncology (ASCO)/College of American Pathologists (CAP) guidelines (immunohistochemistry \[IHC\] and fluorescence in situ hybridization \[FISH\])
* If invasive disease was present in both breasts, participation in the study is permitted as long as the eligibility criteria are met for both tumors/breasts
* Patients must have received neoadjuvant chemotherapy in combination with pembrolizumab for a minimum of 6 cycles. All systemic chemotherapy and ICI therapy should have been completed preoperatively
* An interval of no more than 12 weeks between the completion date of the final surgery and the date of randomization
* Use of investigational anti-cancer agents must be discontinued at time of registration
* Adequate excision: Surgical removal of all clinically evident disease in the breast and lymph nodes as follows:
* Breast surgery: Total mastectomy or breast-conserving surgery with histologically negative margins, including no ink on tumor for DCIS, at the time of excision
* Lymph node surgery:
* For a patient with clinically N0 disease, a sentinel lymph node biopsy should have been performed at time of surgical evaluation, and if pathologically node positive, the patient is no longer eligible. Isolated tumor cells are considered node-negative
* For a patient with clinically N1 disease at diagnosis (with positive results from a fine-needle aspiration, core biopsy, or sentinel node biopsy performed prior to preoperative therapy) additional surgical evaluation of the axilla following preoperative therapy is required
* If sentinel node biopsy performed before preoperative therapy was negative, no additional surgical evaluation of the axilla is required after preoperative therapy. If sentinel node biopsy performed before preoperative therapy was positive, an ALND is required after preoperative therapy
* If the only sentinel node identified by isotope scan is in the internal mammary chain, surgical evaluation of the axilla is still required
* If sentinel node evaluation after preoperative therapy is negative, no further additional surgical evaluation of the axilla is required
* Axillary dissection without sentinel node evaluation is permitted as the initial or sole axillary evaluation after preoperative therapy
* If breast-conserving surgery was performed but patient will not be receiving breast radiation, the patient is not eligible
* Not pregnant and not nursing, because this study involves an agent whose genotoxic, mutagenic and teratogenic effects on the developing fetus and newborn are unknown. Therefore, for women of childbearing potential only, a negative serum or urine pregnancy test done =\< 7 days prior to randomization is required
* Absolute neutrophil count (ANC) \>= 1,000/mm\^3
* Platelet Count \>= 100,000/mm\^3
* Estimated glomerular filtration rate (eGFR) \>= 15 mL/min/1.73m\^2
* Total Bilirubin =\<1.5 x upper limit of normal (ULN)
* Aspartate aminotransferase (AST) serum aspartate aminotransferase \[SGOT\] / alanine aminotransferase (ALT) serum glutamic pyruvic transaminase \[SGPT\] =\< 3 x institutional ULN
* Patients must be willing to provide tumor tissue from the diagnostic core biopsy. If inadequate tumor tissue is available, patients are still eligible to participate in the trial
* Patients with a prior or concurrent malignancy whose natural history or treatment does not have the potential to interfere with the safety or efficacy assessment of the investigational regimen are eligible for this trial
* Patients with known history or current symptoms of cardiac disease, or history of treatment with cardiotoxic agents, should have a clinical risk assessment of cardiac function using the New York Heart Association Functional Classification. To be eligible for this trial, patients should be class 2B or better
* Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months prior to registration are eligible for this trial

* No stage IV (metastatic) breast cancer
* No history of any prior (ipsi- or contralateral) invasive breast cancer. Prior DCIS is allowed
* No evidence of recurrent disease following preoperative therapy and surgery
* No known active liver disease, e.g. due to hepatitis B virus (HBV), hepatitis C virus (HCV), autoimmune hepatic disorders, or sclerosing cholangitis
* No history of intolerance, including Grade 3 or 4 infusion reaction or hypersensitivity to pembrolizumab or murine proteins or any components of the product
* No medical conditions that require chronic systemic steroids (\>10 mg prednisone daily or equivalent) or any other form of immunosuppressive medications and has required such therapy in the last two years. Replacement therapy (e.g. thyroxine, insulin, or physiologic corticosteroid replacement therapy for adrenal or pituitary insufficiency, etc.) is not considered a form of systemic therapy
* Patients who are unable or unwilling to comply with the requirements of the protocol per investigator assessment are not eligible

Contacts and Locations

Study Contact

Sara Tolaney, MD

CONTACT

617-632-2335

Sara_Tolaney@dfci.harvard.edu

Laura Hoffman

CONTACT

773-834-2546

lhoffman22@bsd.uchicago.edu

Study Locations (Sites)

University of Alabama at Birmingham Cancer Center

Birmingham, Alabama, 35233

United States

Thomas Hospital

Fairhope, Alabama, 36532

United States

Mobile Infirmary Medical Center

Mobile, Alabama, 36607

United States

CTCA at Western Regional Medical Center

Goodyear, Arizona, 85338

United States

Kingman Regional Medical Center

Kingman, Arizona, 86401

United States

Cancer Center at Saint Joseph's

Phoenix, Arizona, 85004

United States

Mayo Clinic Hospital in Arizona

Phoenix, Arizona, 85054

United States

Highlands Oncology Group - Fayetteville

Fayetteville, Arkansas, 72703

United States

University of Arkansas for Medical Sciences

Little Rock, Arkansas, 72205

United States

Highlands Oncology Group - Rogers

Rogers, Arkansas, 72758

United States

Highlands Oncology Group

Springdale, Arkansas, 72762

United States

PCR Oncology

Arroyo Grande, California, 93420

United States

Tower Cancer Research Foundation

Beverly Hills, California, 90211

United States

Marshall Cancer Center

Cameron Park, California, 95682

United States

Mercy Cancer Center - Carmichael

Carmichael, California, 95608

United States

Mercy San Juan Medical Center

Carmichael, California, 95608

United States

Kaiser Permanente Dublin

Dublin, California, 94568

United States

Mercy Cancer Center - Elk Grove

Elk Grove, California, 95758

United States

Kaiser Permanente-Fremont

Fremont, California, 94538

United States

Kaiser Permanente-Fresno

Fresno, California, 93720

United States

UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care

Irvine, California, 92612

United States

Cedars Sinai Medical Center

Los Angeles, California, 90048

United States

Fremont - Rideout Cancer Center

Marysville, California, 95901

United States

Kaiser Permanente-Modesto

Modesto, California, 95356

United States

Kaiser Permanente-Oakland

Oakland, California, 94611

United States

UC Irvine Health/Chao Family Comprehensive Cancer Center

Orange, California, 92868

United States

Desert Regional Medical Center

Palm Springs, California, 92262

United States

Stanford Cancer Institute Palo Alto

Palo Alto, California, 94304

United States

Huntington Memorial Hospital

Pasadena, California, 91105

United States

Mercy Cancer Center - Rocklin

Rocklin, California, 95765

United States

Kaiser Permanente-Roseville

Roseville, California, 95661

United States

Kaiser Permanente Downtown Commons

Sacramento, California, 95814

United States

Mercy Cancer Center - Sacramento

Sacramento, California, 95816

United States

University of California Davis Comprehensive Cancer Center

Sacramento, California, 95817

United States

Kaiser Permanente-South Sacramento

Sacramento, California, 95823

United States

Salinas Valley Memorial

Salinas, California, 93901

United States

Zuckerberg San Francisco General Hospital

San Francisco, California, 94110

United States

Kaiser Permanente-San Francisco

San Francisco, California, 94115

United States

Kaiser Permanente-Santa Teresa-San Jose

San Jose, California, 95119

United States

Stanford Cancer Center South Bay

San Jose, California, 95124

United States

Kaiser Permanente San Leandro

San Leandro, California, 94577

United States

Kaiser San Rafael-Gallinas

San Rafael, California, 94903

United States

Kaiser Permanente Medical Center - Santa Clara

Santa Clara, California, 95051

United States

Saint John's Cancer Institute

Santa Monica, California, 90404

United States

Kaiser Permanente-Santa Rosa

Santa Rosa, California, 95403

United States

Kaiser Permanente-South San Francisco

South San Francisco, California, 94080

United States

Cedars-Sinai Cancer - Tarzana

Tarzana, California, 91356

United States

Torrance Memorial Physician Network - Cancer Care

Torrance, California, 90505

United States

Gene Upshaw Memorial Tahoe Forest Cancer Center

Truckee, California, 96161

United States

Kaiser Permanente-Vallejo

Vallejo, California, 94589

United States

Kaiser Permanente-Walnut Creek

Walnut Creek, California, 94596

United States

Woodland Memorial Hospital

Woodland, California, 95695

United States

UCHealth University of Colorado Hospital

Aurora, Colorado, 80045

United States

UCHealth Memorial Hospital Central

Colorado Springs, Colorado, 80909

United States

Memorial Hospital North

Colorado Springs, Colorado, 80920

United States

Kaiser Permanente-Franklin

Denver, Colorado, 80205

United States

UCHealth - Cherry Creek

Denver, Colorado, 80206

United States

UCHealth Highlands Ranch Hospital

Highlands Ranch, Colorado, 80129

United States

Kaiser Permanente-Rock Creek

Lafayette, Colorado, 80026

United States

Kaiser Permanente-Lone Tree

Lone Tree, Colorado, 80124

United States

UCHealth Lone Tree Health Center

Lone Tree, Colorado, 80124

United States

Hartford HealthCare - Saint Vincent's Medical Center

Bridgeport, Connecticut, 06606

United States

Danbury Hospital

Danbury, Connecticut, 06810

United States

Smilow Cancer Hospital-Derby Care Center

Derby, Connecticut, 06418

United States

Smilow Cancer Hospital Care Center-Fairfield

Fairfield, Connecticut, 06824

United States

Smilow Cancer Hospital Care Center at Glastonbury

Glastonbury, Connecticut, 06033

United States

Smilow Cancer Hospital Care Center at Greenwich

Greenwich, Connecticut, 06830

United States

Smilow Cancer Hospital Care Center - Guilford

Guilford, Connecticut, 06437

United States

Hartford Hospital

Hartford, Connecticut, 06102

United States

Smilow Cancer Hospital Care Center at Saint Francis

Hartford, Connecticut, 06105

United States

Midstate Medical Center

Meriden, Connecticut, 06451

United States

The Hospital of Central Connecticut

New Britain, Connecticut, 06050

United States

Yale University

New Haven, Connecticut, 06520

United States

Yale-New Haven Hospital North Haven Medical Center

North Haven, Connecticut, 06473

United States

Norwalk Hospital

Norwalk, Connecticut, 06856

United States

Smilow Cancer Hospital Care Center at Long Ridge

Stamford, Connecticut, 06902

United States

Smilow Cancer Hospital-Torrington Care Center

Torrington, Connecticut, 06790

United States

Smilow Cancer Hospital Care Center-Trumbull

Trumbull, Connecticut, 06611

United States

Smilow Cancer Hospital-Waterbury Care Center

Waterbury, Connecticut, 06708

United States

Smilow Cancer Hospital Care Center - Waterford

Waterford, Connecticut, 06385

United States

Beebe South Coastal Health Campus

Millville, Delaware, 19967

United States

Helen F Graham Cancer Center

Newark, Delaware, 19713

United States

Medical Oncology Hematology Consultants PA

Newark, Delaware, 19713

United States

Beebe Health Campus

Rehoboth Beach, Delaware, 19971

United States

MedStar Georgetown University Hospital

Washington, District of Columbia, 20007

United States

MedStar Washington Hospital Center

Washington, District of Columbia, 20010

United States

Morton Plant Hospital

Clearwater, Florida, 33756

United States

Broward Health Medical Center

Fort Lauderdale, Florida, 33316

United States

University of Florida Health Science Center - Gainesville

Gainesville, Florida, 32610

United States

Mayo Clinic in Florida

Jacksonville, Florida, 32224-9980

United States

Orlando Health Cancer Institute

Orlando, Florida, 32806

United States

Memorial Hospital West

Pembroke Pines, Florida, 33028

United States

Mease Countryside Hospital

Safety Harbor, Florida, 34695

United States

Tallahassee Memorial HealthCare

Tallahassee, Florida, 32308

United States

Tampa General Hospital

Tampa, Florida, 33606

United States

Saint Joseph's Hospital/Children's Hospital-Tampa

Tampa, Florida, 33607

United States

Phoebe Putney Memorial Hospital

Albany, Georgia, 31701

United States

Grady Health System

Atlanta, Georgia, 30303

United States

Emory University Hospital Midtown

Atlanta, Georgia, 30308

United States

Emory University Hospital/Winship Cancer Institute

Atlanta, Georgia, 30322

United States

Emory Saint Joseph's Hospital

Atlanta, Georgia, 30342

United States

Northside Hospital

Atlanta, Georgia, 30342

United States

Augusta Oncology Associates PC-D'Antignac

Augusta, Georgia, 30901

United States

Augusta Oncology Associates PC-Wheeler

Augusta, Georgia, 30909

United States

Northside Hospital - Duluth

Duluth, Georgia, 30096

United States

Northside Hospital - Gwinnett

Lawrenceville, Georgia, 30046

United States

Lewis Cancer and Research Pavilion at Saint Joseph's/Candler

Savannah, Georgia, 31405

United States

Hawaii Cancer Care - Westridge

'Aiea, Hawaii, 96701

United States

Hawaii Cancer Care Inc - Waterfront Plaza

Honolulu, Hawaii, 96813

United States

Queen's Cancer Cenrer - POB I

Honolulu, Hawaii, 96813

United States

Queen's Medical Center

Honolulu, Hawaii, 96813

United States

Straub Clinic and Hospital

Honolulu, Hawaii, 96813

United States

Queen's Cancer Center - Kuakini

Honolulu, Hawaii, 96817

United States

Kaiser Permanente Moanalua Medical Center

Honolulu, Hawaii, 96819

United States

Kapiolani Medical Center for Women and Children

Honolulu, Hawaii, 96826

United States

Saint Alphonsus Cancer Care Center-Boise

Boise, Idaho, 83706

United States

Saint Luke's Cancer Institute - Boise

Boise, Idaho, 83712

United States

Saint Alphonsus Cancer Care Center-Caldwell

Caldwell, Idaho, 83605

United States

Kootenai Health - Coeur d'Alene

Coeur d'Alene, Idaho, 83814

United States

Saint Luke's Cancer Institute - Fruitland

Fruitland, Idaho, 83619

United States

Saint Luke's Cancer Institute - Meridian

Meridian, Idaho, 83642

United States

Saint Luke's Cancer Institute - Nampa

Nampa, Idaho, 83686

United States

Saint Alphonsus Cancer Care Center-Nampa

Nampa, Idaho, 83687

United States

Kootenai Clinic Cancer Services - Post Falls

Post Falls, Idaho, 83854

United States

Kootenai Clinic Cancer Services - Sandpoint

Sandpoint, Idaho, 83864

United States

Saint Luke's Cancer Institute - Twin Falls

Twin Falls, Idaho, 83301

United States

Advocate Good Shepherd Hospital

Barrington, Illinois, 60010

United States

Illinois CancerCare-Bloomington

Bloomington, Illinois, 61704

United States

Illinois CancerCare-Canton

Canton, Illinois, 61520

United States

SIH Cancer Institute

Carterville, Illinois, 62918

United States

Illinois CancerCare-Carthage

Carthage, Illinois, 62321

United States

Centralia Oncology Clinic

Centralia, Illinois, 62801

United States

Northwestern University

Chicago, Illinois, 60611

United States

University of Illinois

Chicago, Illinois, 60612

United States

University of Chicago Comprehensive Cancer Center

Chicago, Illinois, 60637

United States

Advocate Illinois Masonic Medical Center

Chicago, Illinois, 60657

United States

AMG Crystal Lake - Oncology

Crystal Lake, Illinois, 60014

United States

Carle at The Riverfront

Danville, Illinois, 61832

United States

Cancer Care Specialists of Illinois - Decatur

Decatur, Illinois, 62526

United States

Decatur Memorial Hospital

Decatur, Illinois, 62526

United States

Northwestern Medicine Cancer Center Kishwaukee

DeKalb, Illinois, 60115

United States

Illinois CancerCare-Dixon

Dixon, Illinois, 61021

United States

Advocate Good Samaritan Hospital

Downers Grove, Illinois, 60515

United States

Crossroads Cancer Center

Effingham, Illinois, 62401

United States

Advocate Sherman Hospital

Elgin, Illinois, 60123

United States

Illinois CancerCare-Eureka

Eureka, Illinois, 61530

United States

NorthShore University HealthSystem-Evanston Hospital

Evanston, Illinois, 60201

United States

Illinois CancerCare-Galesburg

Galesburg, Illinois, 61401

United States

Northwestern Medicine Cancer Center Delnor

Geneva, Illinois, 60134

United States

NorthShore University HealthSystem-Glenbrook Hospital

Glenview, Illinois, 60026

United States

Northwestern Medicine Glenview Outpatient Center

Glenview, Illinois, 60026

United States

Northwestern Medicine Grayslake Outpatient Center

Grayslake, Illinois, 60030

United States

Ingalls Memorial Hospital

Harvey, Illinois, 60426

United States

Advocate South Suburban Hospital

Hazel Crest, Illinois, 60429

United States

NorthShore University HealthSystem-Highland Park Hospital

Highland Park, Illinois, 60035

United States

Illinois CancerCare-Kewanee Clinic

Kewanee, Illinois, 61443

United States

Northwestern Medicine Lake Forest Hospital

Lake Forest, Illinois, 60045

United States

AMG Libertyville - Oncology

Libertyville, Illinois, 60048

United States

Condell Memorial Hospital

Libertyville, Illinois, 60048

United States

Illinois CancerCare-Macomb

Macomb, Illinois, 61455

United States

Carle Physician Group-Mattoon/Charleston

Mattoon, Illinois, 61938

United States

Trinity Medical Center

Moline, Illinois, 61265

United States

UC Comprehensive Cancer Center at Silver Cross

New Lenox, Illinois, 60451

United States

Cancer Care Center of O'Fallon

O'Fallon, Illinois, 62269

United States

Advocate Christ Medical Center

Oak Lawn, Illinois, 60453-2699

United States

Northwestern Medicine Orland Park

Orland Park, Illinois, 60462

United States

University of Chicago Medicine-Orland Park

Orland Park, Illinois, 60462

United States

Illinois CancerCare-Ottawa Clinic

Ottawa, Illinois, 61350

United States

Advocate Lutheran General Hospital

Park Ridge, Illinois, 60068

United States

Illinois CancerCare-Pekin

Pekin, Illinois, 61554

United States

Illinois CancerCare-Peoria

Peoria, Illinois, 61615

United States

Illinois CancerCare-Peru

Peru, Illinois, 61354

United States

Illinois CancerCare-Princeton

Princeton, Illinois, 61356

United States

OSF Saint Anthony Medical Center

Rockford, Illinois, 61108

United States

UW Health Carbone Cancer Center Rockford

Rockford, Illinois, 61114

United States

Southern Illinois University School of Medicine

Springfield, Illinois, 62702

United States

Springfield Clinic

Springfield, Illinois, 62702

United States

Memorial Medical Center

Springfield, Illinois, 62781

United States

Carle Cancer Center

Urbana, Illinois, 61801

United States

Northwestern Medicine Cancer Center Warrenville

Warrenville, Illinois, 60555

United States

Illinois CancerCare - Washington

Washington, Illinois, 61571

United States

IU Health West Hospital

Avon, Indiana, 46123

United States

IU Health North Hospital

Carmel, Indiana, 46032

United States

Northwest Cancer Center - Main Campus

Crown Point, Indiana, 46307

United States

Northwest Oncology LLC

Dyer, Indiana, 46311

United States

Northwest Cancer Center - Hobart

Hobart, Indiana, 46342

United States

Saint Mary Medical Center

Hobart, Indiana, 46342

United States

Indiana University/Melvin and Bren Simon Cancer Center

Indianapolis, Indiana, 46202

United States

Sidney and Lois Eskenazi Hospital

Indianapolis, Indiana, 46202

United States

Saint Catherine Hospital

Indianapolis, Indiana, 46312

United States

The Community Hospital

Munster, Indiana, 46321

United States

Women's Diagnostic Center - Munster

Munster, Indiana, 46321

United States

Baptist Health Floyd

New Albany, Indiana, 47150

United States

Northwest Cancer Center - Valparaiso

Valparaiso, Indiana, 46383

United States

Physicians' Clinic of Iowa PC

Cedar Rapids, Iowa, 52402

United States

Mercy Hospital

Cedar Rapids, Iowa, 52403

United States

Oncology Associates at Mercy Medical Center

Cedar Rapids, Iowa, 52403

United States

Heartland Oncology and Hematology LLP

Council Bluffs, Iowa, 51503

United States

Methodist Jennie Edmundson Hospital

Council Bluffs, Iowa, 51503

United States

University of Iowa/Holden Comprehensive Cancer Center

Iowa City, Iowa, 52242

United States

Cancer Center of Kansas - Chanute

Chanute, Kansas, 66720

United States

Cancer Center of Kansas - Dodge City

Dodge City, Kansas, 67801

United States

Cancer Center of Kansas - El Dorado

El Dorado, Kansas, 67042

United States

HaysMed

Hays, Kansas, 67601

United States

Cancer Center of Kansas-Independence

Independence, Kansas, 67301

United States

University of Kansas Cancer Center

Kansas City, Kansas, 66160

United States

Cancer Center of Kansas-Kingman

Kingman, Kansas, 67068

United States

Lawrence Memorial Hospital

Lawrence, Kansas, 66044

United States

Cancer Center of Kansas-Liberal

Liberal, Kansas, 67905

United States

Cancer Center of Kansas - McPherson

McPherson, Kansas, 67460

United States

Cancer Center of Kansas - Newton

Newton, Kansas, 67114

United States

Olathe Health Cancer Center

Olathe, Kansas, 66061

United States

Menorah Medical Center

Overland Park, Kansas, 66209

United States

University of Kansas Cancer Center-Overland Park

Overland Park, Kansas, 66210

United States

University of Kansas Hospital-Indian Creek Campus

Overland Park, Kansas, 66211

United States

Cancer Center of Kansas - Parsons

Parsons, Kansas, 67357

United States

Cancer Center of Kansas - Pratt

Pratt, Kansas, 67124

United States

Cancer Center of Kansas - Salina

Salina, Kansas, 67401

United States

Salina Regional Health Center

Salina, Kansas, 67401

United States

University of Kansas Health System Saint Francis Campus

Topeka, Kansas, 66606

United States

Cancer Center of Kansas - Wellington

Wellington, Kansas, 67152

United States

University of Kansas Hospital-Westwood Cancer Center

Westwood, Kansas, 66205

United States

Cancer Center of Kansas-Wichita Medical Arts Tower

Wichita, Kansas, 67208

United States

Ascension Via Christi Hospitals Wichita

Wichita, Kansas, 67214

United States

Cancer Center of Kansas - Wichita

Wichita, Kansas, 67214

United States

Cancer Center of Kansas - Winfield

Winfield, Kansas, 67156

United States

Baptist Health Corbin

Corbin, Kentucky, 40701

United States

Baptist Health Hardin

Elizabethtown, Kentucky, 42701

United States

Baptist Health Lexington

Lexington, Kentucky, 40503

United States

Baptist Health Hamburg

Lexington, Kentucky, 40509

United States

University of Kentucky/Markey Cancer Center

Lexington, Kentucky, 40536

United States

The James Graham Brown Cancer Center at University of Louisville

Louisville, Kentucky, 40202

United States

Baptist Health Louisville

Louisville, Kentucky, 40207

United States

UofL Health Medical Center Northeast

Louisville, Kentucky, 40245

United States

Louisiana Hematology Oncology Associates LLC

Baton Rouge, Louisiana, 70809

United States

Mary Bird Perkins Cancer Center

Baton Rouge, Louisiana, 70809

United States

Medical Center of Baton Rouge

Baton Rouge, Louisiana, 70816

United States

Louisiana Hematology Oncology Associates

Baton Rouge, Louisiana, 70817

United States

Ochsner High Grove

Baton Rouge, Louisiana, 70836

United States

Ochsner Hematology Oncology North Shore - Covington (West Region)

Covington, Louisiana, 70433

United States

Terrebonne General Medical Center

Houma, Louisiana, 70360

United States

University Medical Center New Orleans

New Orleans, Louisiana, 70112

United States

Ochsner Medical Center Jefferson

New Orleans, Louisiana, 70121

United States

CHRISTUS Highland Medical Center

Shreveport, Louisiana, 71105

United States

Luminis Health Anne Arundel Medical Center

Annapolis, Maryland, 21401

United States

University of Maryland/Greenebaum Cancer Center

Baltimore, Maryland, 21201

United States

Sinai Hospital of Baltimore

Baltimore, Maryland, 21215

United States

Walter Reed National Military Medical Center

Bethesda, Maryland, 20889-5600

United States

FMH James M Stockman Cancer Institute

Frederick, Maryland, 21702

United States

William E Kahlert Regional Cancer Center/Sinai Hospital

Westminster, Maryland, 21157

United States

Tufts Medical Center

Boston, Massachusetts, 02111

United States

Boston Medical Center

Boston, Massachusetts, 02118

United States

Beth Israel Deaconess Medical Center

Boston, Massachusetts, 02215

United States

Dana-Farber Cancer Institute

Boston, Massachusetts, 02215

United States

Trinity Health Saint Joseph Mercy Hospital Ann Arbor

Ann Arbor, Michigan, 48106

United States

University of Michigan Comprehensive Cancer Center

Ann Arbor, Michigan, 48109

United States

Bronson Battle Creek

Battle Creek, Michigan, 49017

United States

Trinity Health IHA Medical Group Hematology Oncology - Brighton

Brighton, Michigan, 48114

United States

Trinity Health Medical Center - Brighton

Brighton, Michigan, 48114

United States

Trinity Health IHA Medical Group Hematology Oncology - Canton

Canton, Michigan, 48188

United States

Trinity Health Medical Center - Canton

Canton, Michigan, 48188

United States

Chelsea Hospital

Chelsea, Michigan, 48118

United States

Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital

Chelsea, Michigan, 48118

United States

Henry Ford Macomb Hospital-Clinton Township

Clinton Township, Michigan, 48038

United States

Henry Ford Hospital

Detroit, Michigan, 48202

United States

Genesee Cancer and Blood Disease Treatment Center

Flint, Michigan, 48503

United States

Genesee Hematology Oncology PC

Flint, Michigan, 48503

United States

Genesys Hurley Cancer Institute

Flint, Michigan, 48503

United States

Hurley Medical Center

Flint, Michigan, 48503

United States

Corewell Health Grand Rapids Hospitals - Butterworth Hospital

Grand Rapids, Michigan, 49503

United States

Trinity Health Grand Rapids Hospital

Grand Rapids, Michigan, 49503

United States

Bronson Methodist Hospital

Kalamazoo, Michigan, 49007

United States

West Michigan Cancer Center

Kalamazoo, Michigan, 49007

United States

Ascension Borgess Cancer Center

Kalamazoo, Michigan, 49009

United States

Trinity Health Saint Mary Mercy Livonia Hospital

Livonia, Michigan, 48154

United States

Great Lakes Cancer Management Specialists-Macomb Medical Campus

Macomb, Michigan, 48044

United States

Trinity Health Muskegon Hospital

Muskegon, Michigan, 49444

United States

Corewell Health Lakeland Hospitals - Niles Hospital

Niles, Michigan, 49120

United States

Cancer and Hematology Centers of Western Michigan - Norton Shores

Norton Shores, Michigan, 49444

United States

Henry Ford Health Providence Novi Hospital

Novi, Michigan, 48374

United States

Henry Ford Medical Center-Columbus

Novi, Michigan, 48377

United States

Trinity Health Saint Joseph Mercy Oakland Hospital

Pontiac, Michigan, 48341

United States

Corewell Health Reed City Hospital

Reed City, Michigan, 49677

United States

MyMichigan Medical Center Saginaw

Saginaw, Michigan, 48601

United States

Oncology Hematology Associates of Saginaw Valley PC

Saginaw, Michigan, 48604

United States

Corewell Health Lakeland Hospitals - Marie Yeager Cancer Center

Saint Joseph, Michigan, 49085

United States

Corewell Health Lakeland Hospitals - Saint Joseph Hospital

Saint Joseph, Michigan, 49085

United States

Henry Ford Health Providence Southfield Hospital

Southfield, Michigan, 48075

United States

MyMichigan Medical Center Tawas

Tawas City, Michigan, 48764

United States

Munson Medical Center

Traverse City, Michigan, 49684

United States

Henry Ford West Bloomfield Hospital

West Bloomfield, Michigan, 48322

United States

Saint Mary's Oncology/Hematology Associates of West Branch

West Branch, Michigan, 48661

United States

University of Michigan Health - West

Wyoming, Michigan, 49519

United States

Huron Gastroenterology PC

Ypsilanti, Michigan, 48106

United States

Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus

Ypsilanti, Michigan, 48197

United States

Sanford Joe Lueken Cancer Center

Bemidji, Minnesota, 56601

United States

Essentia Health Saint Joseph's Medical Center

Brainerd, Minnesota, 56401

United States

Minnesota Oncology - Burnsville

Burnsville, Minnesota, 55337

United States

Mercy Hospital

Coon Rapids, Minnesota, 55433

United States

Essentia Health - Deer River Clinic

Deer River, Minnesota, 56636

United States

Essentia Health Cancer Center

Duluth, Minnesota, 55805

United States

Fairview Southdale Hospital

Edina, Minnesota, 55435

United States

Essentia Health Hibbing Clinic

Hibbing, Minnesota, 55746

United States

Saint John's Hospital - Healtheast

Maplewood, Minnesota, 55109

United States

Abbott-Northwestern Hospital

Minneapolis, Minnesota, 55407

United States

Hennepin County Medical Center

Minneapolis, Minnesota, 55415

United States

University of Minnesota/Masonic Cancer Center

Minneapolis, Minnesota, 55455

United States

North Memorial Medical Health Center

Robbinsdale, Minnesota, 55422

United States

Mayo Clinic in Rochester

Rochester, Minnesota, 55905

United States

Coborn Cancer Center at Saint Cloud Hospital

Saint Cloud, Minnesota, 56303

United States

Park Nicollet Clinic - Saint Louis Park

Saint Louis Park, Minnesota, 55416

United States

Regions Hospital

Saint Paul, Minnesota, 55101

United States

United Hospital

Saint Paul, Minnesota, 55102

United States

Essentia Health Sandstone

Sandstone, Minnesota, 55072

United States

Essentia Health Virginia Clinic

Virginia, Minnesota, 55792

United States

Baptist Memorial Hospital and Cancer Center-Golden Triangle

Columbus, Mississippi, 39705

United States

Baptist Cancer Center-Grenada

Grenada, Mississippi, 38901

United States

University of Mississippi Medical Center

Jackson, Mississippi, 39216

United States

Baptist Memorial Hospital and Cancer Center-Union County

New Albany, Mississippi, 38652

United States

Baptist Memorial Hospital and Cancer Center-Oxford

Oxford, Mississippi, 38655

United States

Baptist Memorial Hospital and Cancer Center-Desoto

Southhaven, Mississippi, 38671

United States

Saint Francis Medical Center

Cape Girardeau, Missouri, 63703

United States

MU Health - University Hospital/Ellis Fischel Cancer Center

Columbia, Missouri, 65212

United States

Siteman Cancer Center at West County Hospital

Creve Coeur, Missouri, 63141

United States

Parkland Health Center - Farmington

Farmington, Missouri, 63640

United States

Centerpoint Medical Center LLC

Independence, Missouri, 64057

United States

University Health Truman Medical Center

Kansas City, Missouri, 64108

United States

Saint Luke's Hospital of Kansas City

Kansas City, Missouri, 64111

United States

Research Medical Center

Kansas City, Missouri, 64132

United States

University of Kansas Cancer Center - North

Kansas City, Missouri, 64154

United States

University of Kansas Cancer Center - Lee's Summit

Lee's Summit, Missouri, 64064

United States

Saint Luke's East - Lee's Summit

Lee's Summit, Missouri, 64086

United States

University of Kansas Cancer Center at North Kansas City Hospital

North Kansas City, Missouri, 64116

United States

Heartland Regional Medical Center

Saint Joseph, Missouri, 64506

United States

Washington University School of Medicine

Saint Louis, Missouri, 63110

United States

Siteman Cancer Center-South County

Saint Louis, Missouri, 63129

United States

Missouri Baptist Medical Center

Saint Louis, Missouri, 63131

United States

Siteman Cancer Center at Christian Hospital

Saint Louis, Missouri, 63136

United States

Mercy Hospital Saint Louis

Saint Louis, Missouri, 63141

United States

Siteman Cancer Center at Saint Peters Hospital

Saint Peters, Missouri, 63376

United States

Sainte Genevieve County Memorial Hospital

Sainte Genevieve, Missouri, 63670

United States

Mercy Hospital Springfield

Springfield, Missouri, 65804

United States

CoxHealth South Hospital

Springfield, Missouri, 65807

United States

Missouri Baptist Sullivan Hospital

Sullivan, Missouri, 63080

United States

BJC Outpatient Center at Sunset Hills

Sunset Hills, Missouri, 63127

United States

Community Hospital of Anaconda

Anaconda, Montana, 59711

United States

Billings Clinic Cancer Center

Billings, Montana, 59101

United States

Bozeman Health Deaconess Hospital

Bozeman, Montana, 59715

United States

Benefis Sletten Cancer Institute

Great Falls, Montana, 59405

United States

Kalispell Regional Medical Center

Kalispell, Montana, 59901

United States

Saint Patrick Hospital - Community Hospital

Missoula, Montana, 59802

United States

Community Medical Center

Missoula, Montana, 59804

United States

Nebraska Medicine-Bellevue

Bellevue, Nebraska, 68123

United States

Mary Lanning Memorial Hospital

Hastings, Nebraska, 68901

United States

Nebraska Cancer Specialists/Oncology Hematology West PC - MECC

Omaha, Nebraska, 68114

United States

Nebraska Methodist Hospital

Omaha, Nebraska, 68114

United States

Oncology Associates PC

Omaha, Nebraska, 68114

United States

Nebraska Medicine-Village Pointe

Omaha, Nebraska, 68118

United States

University of Nebraska Medical Center

Omaha, Nebraska, 68198

United States

OptumCare Cancer Care at Seven Hills

Henderson, Nevada, 89052

United States

OptumCare Cancer Care at Charleston

Las Vegas, Nevada, 89102

United States

OptumCare Cancer Care at Fort Apache

Las Vegas, Nevada, 89148

United States

Renown Regional Medical Center

Reno, Nevada, 89502

United States

New Hampshire Oncology Hematology PA-Concord

Concord, New Hampshire, 03301

United States

Solinsky Center for Cancer Care

Manchester, New Hampshire, 03103

United States

Englewood Hospital and Medical Center

Englewood, New Jersey, 07631

United States

Hackensack University Medical Center

Hackensack, New Jersey, 07601

United States

The Cancer Institute of New Jersey Hamilton

Hamilton, New Jersey, 08690

United States

Jersey City Medical Center

Jersey City, New Jersey, 07302

United States

Monmouth Medical Center Southern Campus

Lakewood, New Jersey, 08701

United States

Saint Barnabas Medical Center

Livingston, New Jersey, 07039

United States

Monmouth Medical Center

Long Branch, New Jersey, 07740

United States

Morristown Medical Center

Morristown, New Jersey, 07960

United States

Inspira Medical Center Mullica Hill

Mullica Hill, New Jersey, 08062

United States

Rutgers Cancer Institute of New Jersey

New Brunswick, New Jersey, 08903

United States

The Valley Hospital - Luckow Pavilion

Paramus, New Jersey, 07652

United States

Valley Health System Ridgewood Campus

Ridgewood, New Jersey, 07450

United States

Sidney Kimmel Cancer Center Washington Township

Sewell, New Jersey, 08080

United States

Robert Wood Johnson University Hospital Somerset

Somerville, New Jersey, 08876

United States

Overlook Hospital

Summit, New Jersey, 07902

United States

University of New Mexico Cancer Center

Albuquerque, New Mexico, 87106

United States

Presbyterian Kaseman Hospital

Albuquerque, New Mexico, 87110

United States

Presbyterian Rust Medical Center/Jorgensen Cancer Center

Rio Rancho, New Mexico, 87124

United States

Northwell Health Imbert Cancer Center

Bay Shore, New York, 11706

United States

Montefiore Medical Center-Einstein Campus

Bronx, New York, 10461

United States

Maimonides Medical Center

Brooklyn, New York, 11219

United States

NYU Langone Hospital - Brooklyn

Brooklyn, New York, 11220

United States

Roswell Park Cancer Institute

Buffalo, New York, 14263

United States

Hematology Oncology Associates of CNY at Camillus

Camillus, New York, 13031

United States

Hematology Oncology Associates of Central New York-East Syracuse

East Syracuse, New York, 13057

United States

Northwell Health Cancer Institute at Huntington

Greenlawn, New York, 11740

United States

Northwell Health/Center for Advanced Medicine

Lake Success, New York, 11042

United States

NYU Langone Hospital - Long Island

Mineola, New York, 11501

United States

Northern Westchester Hospital

Mount Kisco, New York, 10549

United States

Mount Sinai Chelsea

New York, New York, 10011

United States

Laura and Isaac Perlmutter Cancer Center at NYU Langone

New York, New York, 10016

United States

Mount Sinai West

New York, New York, 10019

United States

Lenox Hill Hospital

New York, New York, 10021

United States

Mount Sinai Hospital

New York, New York, 10029

United States

NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center

New York, New York, 10032

United States

Manhattan Eye Ear and Throat Hospital

New York, New York, 10065

United States

Vassar Brothers Medical Center

Poughkeepsie, New York, 12601

United States

Pluta Cancer Center

Rochester, New York, 14623

United States

University of Rochester

Rochester, New York, 14642

United States

Phelps Memorial Hospital Center

Sleepy Hollow, New York, 10591

United States

Staten Island University Hospital

Staten Island, New York, 10305

United States

Stony Brook University Medical Center

Stony Brook, New York, 11794

United States

Wilmot Cancer Institute at Webster

Webster, New York, 14580

United States

Cone Health Cancer Center at Asheboro

Asheboro, North Carolina, 27203

United States

Randolph Health Cancer Center

Asheboro, North Carolina, 27203

United States

Cone Health Cancer Center at Alamance Regional

Burlington, North Carolina, 27215

United States

Rex Hematology Oncology Associates-Cary

Cary, North Carolina, 27518

United States

UNC Lineberger Comprehensive Cancer Center

Chapel Hill, North Carolina, 27599

United States

Novant Health Presbyterian Medical Center

Charlotte, North Carolina, 28204

United States

Rex Hematology Oncology Associates-Garner

Garner, North Carolina, 27529

United States

Cone Health Cancer Center

Greensboro, North Carolina, 27403

United States

Cone Health Cancer Center at Drawbridge Parkway

Greensboro, North Carolina, 27410

United States

East Carolina University

Greenville, North Carolina, 27834

United States

Margaret R Pardee Memorial Hospital

Hendersonville, North Carolina, 28791

United States

Novant Health Cancer Institute - Huntersville

Huntersville, North Carolina, 28078

United States

Novant Health Presbyterian Medical Center Huntersville

Huntersville, North Carolina, 28078

United States

Novant Health Cancer Institute - Kernersville

Kernersville, North Carolina, 27284

United States

Novant Health Cancer Institute - Matthews

Matthews, North Carolina, 28105

United States

Novant Health Cancer Institute - Mooresville

Mooresville, North Carolina, 28117

United States

Novant Health Cancer Institute - Mount Airy

Mount Airy, North Carolina, 27030

United States

FirstHealth of the Carolinas-Moore Regional Hospital

Pinehurst, North Carolina, 28374

United States

UNC Rex Healthcare

Raleigh, North Carolina, 27607

United States

UNC Rex Cancer Center of Wakefield

Raleigh, North Carolina, 27614

United States

Annie Penn Memorial Hospital

Reidsville, North Carolina, 27320

United States

Novant Health Cancer Institute - Rowan

Salisbury, North Carolina, 28144

United States

Rowan Regional Medical Center

Salisbury, North Carolina, 28144

United States

Novant Health Cancer Institute - Thomasville

Thomasville, North Carolina, 27360

United States

Marion L Shepard Cancer Center - ECU Health Beaufort Hospital

Washington, North Carolina, 27889

United States

Novant Health Forsyth Medical Center

Winston-Salem, North Carolina, 27103

United States

Sanford Bismarck Medical Center

Bismarck, North Dakota, 58501

United States

Essentia Health Cancer Center-South University Clinic

Fargo, North Dakota, 58103

United States

Sanford Broadway Medical Center

Fargo, North Dakota, 58122

United States

Sanford Roger Maris Cancer Center

Fargo, North Dakota, 58122

United States

Summa Health System - Akron Campus

Akron, Ohio, 44304

United States

Summa Health System - Barberton Campus

Barberton, Ohio, 44203

United States

Strecker Cancer Center-Belpre

Belpre, Ohio, 45714

United States

Miami Valley Hospital South

Centerville, Ohio, 45459

United States

Adena Regional Medical Center

Chillicothe, Ohio, 45601

United States

University of Cincinnati Cancer Center-UC Medical Center

Cincinnati, Ohio, 45219

United States

Good Samaritan Hospital - Cincinnati

Cincinnati, Ohio, 45220

United States

Ohio State University Comprehensive Cancer Center

Columbus, Ohio, 43210

United States

Mount Carmel East Hospital

Columbus, Ohio, 43213

United States

The Mark H Zangmeister Center

Columbus, Ohio, 43219

United States

Premier Blood and Cancer Center

Dayton, Ohio, 45409

United States

Dayton Physician LLC - Englewood

Dayton, Ohio, 45415

United States

Miami Valley Hospital North

Dayton, Ohio, 45415

United States

Atrium Medical Center-Middletown Regional Hospital

Franklin, Ohio, 45005-1066

United States

Miami Valley Cancer Care and Infusion

Greenville, Ohio, 45331

United States

Mount Carmel Grove City Hospital

Grove City, Ohio, 43123

United States

Zangmeister Center Grove City

Grove City, Ohio, 43123

United States

Kettering Medical Center

Kettering, Ohio, 45429

United States

Fairfield Medical Center

Lancaster, Ohio, 43130

United States

Memorial Hospital

Marysville, Ohio, 43040

United States

Summa Health Medina Medical Center

Medina, Ohio, 44256

United States

Licking Memorial Hospital

Newark, Ohio, 43055

United States

Mercy Health Perrysburg Cancer Center

Perrysburg, Ohio, 43551

United States

Southern Ohio Medical Center

Portsmouth, Ohio, 45662

United States

Springfield Regional Cancer Center

Springfield, Ohio, 45504

United States

ProMedica Flower Hospital

Sylvania, Ohio, 43560

United States

Mercy Health - Saint Anne Hospital

Toledo, Ohio, 43623

United States

Toledo Clinic Cancer Centers-Toledo

Toledo, Ohio, 43623

United States

Upper Valley Medical Center

Troy, Ohio, 45373

United States

University of Cincinnati Cancer Center-West Chester

West Chester, Ohio, 45069

United States

Saint Ann's Hospital

Westerville, Ohio, 43081

United States

Genesis Healthcare System Cancer Care Center

Zanesville, Ohio, 43701

United States

University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, 73104

United States

Mercy Hospital Oklahoma City

Oklahoma City, Oklahoma, 73120

United States

Clackamas Radiation Oncology Center

Clackamas, Oregon, 97015

United States

Providence Cancer Institute Clackamas Clinic

Clackamas, Oregon, 97015

United States

Three Rivers Community Hospital

Grants Pass, Oregon, 97527

United States

Legacy Mount Hood Medical Center

Gresham, Oregon, 97030

United States

Asante Rogue Regional Medical Center

Medford, Oregon, 97504

United States

Providence Newberg Medical Center

Newberg, Oregon, 97132

United States

Saint Alphonsus Cancer Care Center-Ontario

Ontario, Oregon, 97914

United States

Providence Willamette Falls Medical Center

Oregon City, Oregon, 97045

United States

Legacy Good Samaritan Hospital and Medical Center

Portland, Oregon, 97210

United States

Providence Portland Medical Center

Portland, Oregon, 97213

United States

Providence Saint Vincent Medical Center

Portland, Oregon, 97225

United States

Kaiser Permanente Northwest

Portland, Oregon, 97227

United States

Legacy Meridian Park Hospital

Tualatin, Oregon, 97062

United States

Lehigh Valley Hospital-Cedar Crest

Allentown, Pennsylvania, 18103

United States

Lehigh Valley Hospital - Muhlenberg

Bethlehem, Pennsylvania, 18017

United States

Geisinger Medical Center

Danville, Pennsylvania, 17822

United States

Pocono Medical Center

East Stroudsburg, Pennsylvania, 18301

United States

Saint Vincent Hospital

Erie, Pennsylvania, 16544

United States

Penn State Milton S Hershey Medical Center

Hershey, Pennsylvania, 17033-0850

United States

Jefferson Hospital

Jefferson Hills, Pennsylvania, 15025

United States

Forbes Hospital

Monroeville, Pennsylvania, 15146

United States

Thomas Jefferson University Hospital

Philadelphia, Pennsylvania, 19107

United States

Jefferson Torresdale Hospital

Philadelphia, Pennsylvania, 19114

United States

Allegheny General Hospital

Pittsburgh, Pennsylvania, 15212

United States

Guthrie Medical Group PC-Robert Packer Hospital

Sayre, Pennsylvania, 18840

United States

Community Medical Center

Scranton, Pennsylvania, 18510

United States

Wexford Health and Wellness Pavilion

Wexford, Pennsylvania, 15090

United States

Geisinger Wyoming Valley/Henry Cancer Center

Wilkes-Barre, Pennsylvania, 18711

United States

Asplundh Cancer Pavilion

Willow Grove, Pennsylvania, 19090

United States

Rhode Island Hospital

Providence, Rhode Island, 02903

United States

Women and Infants Hospital

Providence, Rhode Island, 02905

United States

Smilow Cancer Hospital Care Center - Westerly

Westerly, Rhode Island, 02891

United States

Saint Joseph's/Candler - Bluffton Campus

Bluffton, South Carolina, 29910

United States

Prisma Health Cancer Institute - Spartanburg

Boiling Springs, South Carolina, 29316

United States

Medical University of South Carolina

Charleston, South Carolina, 29425

United States

Prisma Health Cancer Institute - Easley

Easley, South Carolina, 29640

United States

McLeod Regional Medical Center

Florence, South Carolina, 29506

United States

Tidelands Georgetown Memorial Hospital

Georgetown, South Carolina, 29440

United States

Saint Francis Hospital

Greenville, South Carolina, 29601

United States

Prisma Health Cancer Institute - Butternut

Greenville, South Carolina, 29605

United States

Prisma Health Cancer Institute - Faris

Greenville, South Carolina, 29605

United States

Saint Francis Cancer Center

Greenville, South Carolina, 29607

United States

Prisma Health Cancer Institute - Eastside

Greenville, South Carolina, 29615

United States

Self Regional Healthcare

Greenwood, South Carolina, 29646

United States

Prisma Health Cancer Institute - Greer

Greer, South Carolina, 29650

United States

South Carolina Cancer Specialists PC

Hilton Head Island, South Carolina, 29926-3827

United States

Prisma Health Cancer Institute - Seneca

Seneca, South Carolina, 29672

United States

Lexington Medical Center

West Columbia, South Carolina, 29169

United States

Avera Cancer Institute-Aberdeen

Aberdeen, South Dakota, 57401

United States

Avera Cancer Institute at Pierre

Pierre, South Dakota, 57501

United States

Sanford Cancer Center Oncology Clinic

Sioux Falls, South Dakota, 57104

United States

Avera Cancer Institute

Sioux Falls, South Dakota, 57105

United States

Sanford USD Medical Center - Sioux Falls

Sioux Falls, South Dakota, 57117-5134

United States

Baptist Memorial Hospital and Cancer Center-Collierville

Collierville, Tennessee, 38017

United States

University of Tennessee - Knoxville

Knoxville, Tennessee, 37920

United States

Baptist Memorial Hospital and Cancer Center-Memphis

Memphis, Tennessee, 38120

United States

Vanderbilt Breast Center at One Hundred Oaks

Nashville, Tennessee, 37204

United States

Vanderbilt University/Ingram Cancer Center

Nashville, Tennessee, 37232

United States

Houston Methodist San Jacinto Hospital

Baytown, Texas, 77521

United States

MD Anderson in The Woodlands

Conroe, Texas, 77384

United States

Parkland Memorial Hospital

Dallas, Texas, 75235

United States

UT Southwestern Simmons Cancer Center - RedBird

Dallas, Texas, 75237

United States

UT Southwestern/Simmons Cancer Center-Dallas

Dallas, Texas, 75390

United States

Tarrant County Hospital District/JPS Health Network

Fort Worth, Texas, 76104

United States

UT Southwestern/Simmons Cancer Center-Fort Worth

Fort Worth, Texas, 76104

United States

Lyndon Baines Johnson General Hospital

Houston, Texas, 77026-1967

United States

Baylor College of Medicine/Dan L Duncan Comprehensive Cancer Center

Houston, Texas, 77030

United States

Ben Taub General Hospital

Houston, Texas, 77030

United States

Houston Methodist Hospital

Houston, Texas, 77030

United States

M D Anderson Cancer Center

Houston, Texas, 77030

United States

Methodist Willowbrook Hospital

Houston, Texas, 77070

United States

MD Anderson West Houston

Houston, Texas, 77079

United States

Houston Methodist West Hospital

Houston, Texas, 77094

United States

MD Anderson League City

League City, Texas, 77573

United States

Houston Methodist Saint John Hospital

Nassau Bay, Texas, 77058

United States

UT Southwestern Clinical Center at Richardson/Plano

Richardson, Texas, 75080

United States

MD Anderson in Sugar Land

Sugar Land, Texas, 77478

United States

Houston Methodist Sugar Land Hospital

Sugar Land, Texas, 77479

United States

Houston Methodist The Woodlands Hospital

The Woodlands, Texas, 77385

United States

University of Vermont Medical Center

Burlington, Vermont, 05401

United States

Inova Schar Cancer Institute

Fairfax, Virginia, 22031

United States

Inova Fair Oaks Hospital

Fairfax, Virginia, 22033

United States

Inova Fairfax Hospital

Falls Church, Virginia, 22042

United States

Augusta Health Center for Cancer and Blood Disorders

Fishersville, Virginia, 22939

United States

Bon Secours Memorial Regional Medical Center

Mechanicsville, Virginia, 23116

United States

Bon Secours Saint Francis Medical Center

Midlothian, Virginia, 23114

United States

Bon Secours Saint Mary's Hospital

Richmond, Virginia, 23226

United States

VCU Massey Cancer Center at Stony Point

Richmond, Virginia, 23235

United States

Virginia Commonwealth University/Massey Cancer Center

Richmond, Virginia, 23298

United States

Swedish Cancer Institute-Edmonds

Edmonds, Washington, 98026

United States

Swedish Cancer Institute-Issaquah

Issaquah, Washington, 98029

United States

Valley Medical Center

Renton, Washington, 98055

United States

Fred Hutchinson Cancer Center

Seattle, Washington, 98109

United States

Swedish Medical Center-First Hill

Seattle, Washington, 98122

United States

University of Washington Medical Center - Montlake

Seattle, Washington, 98195

United States

Legacy Cancer Institute Medical Oncology and Day Treatment

Vancouver, Washington, 98684

United States

Legacy Salmon Creek Hospital

Vancouver, Washington, 98686

United States

North Star Lodge Cancer Center at Yakima Valley Memorial Hospital

Yakima, Washington, 98902

United States

Edwards Comprehensive Cancer Center

Huntington, West Virginia, 25701

United States

Camden Clark Medical Center

Parkersburg, West Virginia, 26101

United States

Langlade Hospital and Cancer Center

Antigo, Wisconsin, 54409

United States

ThedaCare Regional Cancer Center

Appleton, Wisconsin, 54911

United States

Duluth Clinic Ashland

Ashland, Wisconsin, 54806

United States

ThedaCare Cancer Care - Berlin

Berlin, Wisconsin, 54923

United States

Aurora Cancer Care-Southern Lakes VLCC

Burlington, Wisconsin, 53105

United States

Marshfield Medical Center-EC Cancer Center

Eau Claire, Wisconsin, 54701

United States

Aurora Health Care Germantown Health Center

Germantown, Wisconsin, 53022

United States

Aurora Cancer Care-Grafton

Grafton, Wisconsin, 53024

United States

Saint Vincent Hospital Cancer Center Green Bay

Green Bay, Wisconsin, 54301

United States

Saint Vincent Hospital Cancer Center at Saint Mary's

Green Bay, Wisconsin, 54303

United States

Aurora BayCare Medical Center

Green Bay, Wisconsin, 54311

United States

Mercyhealth Hospital and Cancer Center - Janesville

Janesville, Wisconsin, 53548

United States

University of Wisconsin Carbone Cancer Center - Johnson Creek

Johnson Creek, Wisconsin, 53038

United States

Aurora Cancer Care-Kenosha South

Kenosha, Wisconsin, 53142

United States

Gundersen Lutheran Medical Center

La Crosse, Wisconsin, 54601

United States

University of Wisconsin Carbone Cancer Center - University Hospital

Madison, Wisconsin, 53792

United States

Aurora Bay Area Medical Group-Marinette

Marinette, Wisconsin, 54143

United States

Marshfield Medical Center-Marshfield

Marshfield, Wisconsin, 54449

United States

Aspirus Medford Hospital

Medford, Wisconsin, 54451

United States

Froedtert Menomonee Falls Hospital

Menomonee Falls, Wisconsin, 53051

United States

Aurora Cancer Care-Milwaukee

Milwaukee, Wisconsin, 53209

United States

Aurora Saint Luke's Medical Center

Milwaukee, Wisconsin, 53215

United States

Medical College of Wisconsin

Milwaukee, Wisconsin, 53226

United States

Aurora Sinai Medical Center

Milwaukee, Wisconsin, 53233

United States

Marshfield Clinic-Minocqua Center

Minocqua, Wisconsin, 54548

United States

ProHealth D N Greenwald Center

Mukwonago, Wisconsin, 53149

United States

ThedaCare Regional Medical Center - Neenah

Neenah, Wisconsin, 54956

United States

ThedaCare Cancer Care - New London

New London, Wisconsin, 54961

United States

Drexel Town Square Health Center

Oak Creek, Wisconsin, 53154

United States

ProHealth Oconomowoc Memorial Hospital

Oconomowoc, Wisconsin, 53066

United States

Saint Vincent Hospital Cancer Center at Oconto Falls

Oconto Falls, Wisconsin, 54154

United States

ThedaCare Cancer Care - Oshkosh

Oshkosh, Wisconsin, 54904

United States

Vince Lombardi Cancer Clinic - Oshkosh

Oshkosh, Wisconsin, 54904

United States

Aurora Cancer Care-Racine

Racine, Wisconsin, 53406

United States

Ascension Saint Mary's Hospital

Rhinelander, Wisconsin, 54501

United States

ThedaCare Cancer Care - Shawano

Shawano, Wisconsin, 54166

United States

Saint Vincent Hospital Cancer Center at Sheboygan

Sheboygan, Wisconsin, 53081

United States

Vince Lombardi Cancer Clinic-Sheboygan

Sheboygan, Wisconsin, 53081

United States

Ascension Saint Michael's Hospital

Stevens Point, Wisconsin, 54481

United States

Marshfield Medical Center-River Region at Stevens Point

Stevens Point, Wisconsin, 54482

United States

Saint Vincent Hospital Cancer Center at Sturgeon Bay

Sturgeon Bay, Wisconsin, 54235-1495

United States

Aurora Medical Center in Summit

Summit, Wisconsin, 53066

United States

Vince Lombardi Cancer Clinic-Two Rivers

Two Rivers, Wisconsin, 54241

United States

UW Cancer Center at ProHealth Care

Waukesha, Wisconsin, 53188

United States

ThedaCare Cancer Care - Waupaca

Waupaca, Wisconsin, 54981

United States

Aspirus Regional Cancer Center

Wausau, Wisconsin, 54401

United States

Aurora Cancer Care-Milwaukee West

Wauwatosa, Wisconsin, 53226

United States

Aurora West Allis Medical Center

West Allis, Wisconsin, 53227

United States

Froedtert West Bend Hospital/Kraemer Cancer Center

West Bend, Wisconsin, 53095

United States

Marshfield Medical Center - Weston

Weston, Wisconsin, 54476

United States

Aspirus Cancer Care - Wisconsin Rapids

Wisconsin Rapids, Wisconsin, 54494

United States

Collaborators and Investigators

Sponsor: Alliance for Clinical Trials in Oncology

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-06-14

Study Completion Date2033-05-31

Study Record Updates

Study Start Date2023-06-14

Study Completion Date2033-05-31

Terms related to this study

Additional Relevant MeSH Terms

Anatomic Stage I Breast Cancer AJCC v8
Anatomic Stage II Breast Cancer AJCC v8
Anatomic Stage III Breast Cancer AJCC v8
Early Stage Triple-Negative Breast Carcinoma