Herniorrhaphy for Postoperative Pain

Eligibility Criteria

• * Able to sign Informed Consent
• * Scheduled to have inguinal hernia repair
• * Be a reasonably healthy adult 18 - 75 years of age
• * Body mass index ≤ 39 kg/m2
• * If biologically female, not pregnant or planning to become pregnant
• * If biologically male, using acceptable birth control
• * Be willing and able to complete study procedures
• * Previously inguinal herniorrhaphy
• * Concurrent painful condition that may require analgesic treatment
• * History or clinical manifestation of significant medical, neuropsychiatric, or other condition, significant abnormal clinical laboratory test value, or known bleeding abnormality that could preclude or impair study participation
• * Clinically significant existing arrhythmia, bundle branch block or abnormal ECG, myocardial infarction, or coronary arterial bypass graft surgery within the prior 12 months
• * History of malignant hyperthermia or glucose-6-phosphate dehydrogenase deficiency.
• * Impaired liver function (e.g., alanine aminotransferase \[ALT\] \> 3 × upper limit of normal \[ULN\] or total bilirubin \> 2 × ULN), active hepatic disease, or cirrhosis.
• * Impaired renal function (e.g., creatinine \> 1.5 × ULN).
• * Malignancy in the past year
• * Known or suspected daily use of opioids for 7 or more consecutive days within the previous 6 months.