RECRUITING

Supraspinal Processing of Sensory Aspects of Pain

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The goal of this basic science study is to learn about the brain mechanisms of chronic pain across different chronic pain syndromes in pediatric patients. The main questions it aims to answer are: * Are there shared and distinct brain systems engaged by different forms of pediatric chronic pain? * What are predictors of recovery from chronic pain? * What brain systems are associated with the spread of pain? For this study participants will undergo: * Functional Magnetic Resonance Imaging (fMRI) * Quantitative Sensory Testing * Psychological Assessments

Official Title

Supraspinal Processing of Sensory Aspects of Pain

Quick Facts

Study Start:2023-05-01
Study Completion:2027-06-30
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05814497

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:10 Years to 17 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:CHILD
Inclusion CriteriaExclusion Criteria
  1. * Patients will need a diagnosis of a chronic pain derived congruent with ICD-11 criteria related to headache (migraine, daily headache), abdominal (FAPD), localized MSK (single limb/joint, low back or chest pain), diffuse MSK (widespread MSK pain), or CRPS
  2. * If on medications, they need to be on stable doses of prescribed pain and/or psychiatric medications for 4 weeks before the baseline study visit.
  3. * Male or female, age 10 -17 (inclusive)
  4. * English speaking, able to complete interviews and questionnaires in English
  1. * Weight/size incompatible with MRI scanner
  2. * Orthodontic braces, metallic or electronic implants, or other metal objects in the body which obscure or interfere with the MRI, or pose a risk from heating, movement, or malfunction in the MRI environment
  3. * Claustrophobia
  4. * Youth who are pregnant
  5. * Any comorbid rheumatic disease, diagnosis of epilepsy, other neurological diseases, or medical condition (e.g. diabetes, cancer, IBD)
  6. * Present psychiatric disease as defined by DSM IV (e.g. psychosis, bipolar disorder, major depression, generalized anxiety disorder), alcohol or drug dependence, or documented developmental delays or impairments (e.g., autism, cerebral palsy, ADHD, or mental retardation) that, in the opinion of the investigator, would interfere with adherence to study requirements or safe participation in the study
  7. * Skin conditions or past skin damage on the arms or legs in or near sites of sensory testing
  8. * Outside the age range (9 years old or younger; 18 years or older) at the time of consent
  9. * History of \> 1 month opioid treatment.

Contacts and Locations

Study Contact

Catherine Jackson, MSc
CONTACT
5136360669
Catherine.Jackson@cchmc.org
Hannah Schildmeyer, BS
CONTACT
Hannah.Schildmeyer@cchmc.org

Principal Investigator

Robert Coghill, PhD
PRINCIPAL_INVESTIGATOR
Children's Hospital Medical Center, Cincinnati

Study Locations (Sites)

Cincinnati Children's Hospital
Cincinnati, Ohio, 45229
United States

Collaborators and Investigators

Sponsor: Children's Hospital Medical Center, Cincinnati

  • Robert Coghill, PhD, PRINCIPAL_INVESTIGATOR, Children's Hospital Medical Center, Cincinnati

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-05-01
Study Completion Date2027-06-30

Study Record Updates

Study Start Date2023-05-01
Study Completion Date2027-06-30

Terms related to this study

Keywords Provided by Researchers

  • chronic pain

Additional Relevant MeSH Terms

  • Migraine in Children
  • Complex Regional Pain Syndromes
  • Musculoskeletal Pain
  • Functional Abdominal Pain Syndrome
  • Fibromyalgia