Myopia Control: a Comparison Study Between Atropine and MiSight

Eligibility Criteria

• * Children age of 5-12 years old at their baseline exam
• * Children with a spherical equivalent refractive error of +0.50D (minimal hyperopia) to -7.50 D (high myopia)
• * Gestational age ≥ 32 weeks.
• * Birth weight \>1500g.
• * Current or previous form of myopia control
• * Current or previous use of bifocal, progressive- addition lenses, or multifocal contact lenses
• * Known atropine allergy or contact lens intolerance (allergy to only one can still allow enrollment in the other group)
• * Abnormality of cornea, lens, central retina, iris, or ciliary body
• * Current or prior history of manifest strabismus, amblyopia, or nystagmus
• * Current or previous myopia treatment with atropine, pirenzepine or another anti-muscarinic agent.
• * Current or previous use of bifocals, progressive-addition lenses, or multi-focal contact lenses.
• * Current or previous use of orthoK, rigid gas permeable, or other contact lenses being used to reduce myopia progression.
• * Abnormality of the cornea, lens, central retina, iris, or ciliary body.
• * Prior eyelid, strabismus, intraocular, or refractive surgery.
• * Down syndrome or cerebral palsy.
• * Diseases known to affect accommodation, vergence, or ocular motility (e.g., multiple sclerosis, Grave's disease, myasthenia gravis, diabetes mellitus, Parkinson's disease)
• * Existing ocular conditions (e.g., retinal disease, cataracts, ptosis) or systemic/neurodevelopmental conditions (e.g., Down syndrome) which may influence refractive development
• * Any condition that in the judgement of the investigator could potentially influence refractive development.
• * Existing conditions that may affect the long-term health of the eye or require regular pharmacologic treatment that may adversely interact with study medication (e.g., JIA, glaucoma, diabetes mellitus, pre-diabetes)
• * Inability to comprehend and/or perform any study-related clinical tests