LUng voluMe reductIoN by DuAl ENergy CT Evaluation (LUMINANCE) Study

Description

The purpose of this research study is to see if a special CT scan (dual-energy CT) provides useful information in patients undergoing bronchsoscopic lung volume reduction (valve placement for emphysema). The investigators will enroll up to 30 participants in this study from University Hospitals Cleveland Medical Center. All of the participants from this study will undergo their valve procedure at University Hospitals Cleveland Medical Center.

Conditions

Lung Perfusion

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Study Overview

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Study Details

Study overview

The purpose of this research study is to see if a special CT scan (dual-energy CT) provides useful information in patients undergoing bronchsoscopic lung volume reduction (valve placement for emphysema). The investigators will enroll up to 30 participants in this study from University Hospitals Cleveland Medical Center. All of the participants from this study will undergo their valve procedure at University Hospitals Cleveland Medical Center.

LUng voluMe reductIoN by DuAl ENergy CT Evaluation (LUMINANCE) Study

LUng voluMe reductIoN by DuAl ENergy CT Evaluation (LUMINANCE) Study

Condition
Lung Perfusion
Intervention / Treatment

-

Contacts and Locations

Cleveland

University Hospitals Cleveland Medical Center, Cleveland, Ohio, United States, 44106

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Adult patients (≥ 18 years of age at the time of written informed consent) with emphysema who have been deemed appropriate candidates for bronchoscopic lung volume reduction
  • * Patients unable to provide consent
  • * Patients who are pregnant or nursing
  • * Women of child-bearing age will undergo pregnancy tests based on University Hospital (UH) standard bronchoscopy pre-procedural testing
  • * Patients unable to undergo a DECT chest (contraindications to a CT chest with intravenous contrast such as a reported or documented allergy to intravenous (IV) contrast or impaired renal function, defined as the following:
  • * Glomerular filtration rate (GFR) \<90 ml/min/1.73 m2 at the time of initial evaluation if patient age is ≤ 59 years
  • * GFR \<85 ml/min/1.73 m2 if patient age is 60-69 years
  • * GFR \<75 ml/min/1.73 m2 if patient age is ≥70 years

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Sameer Avasarala,

Sameer Avasarala, MD, PRINCIPAL_INVESTIGATOR, University Hospitals

Study Record Dates

2024-10-01