Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
For general information about clinical research, read Learn About Studies.
Eligibility Criteria
- * Males and females between 40 and 75 years of age capable and willing to provide informed consent
- * Participant has high CAD PRS as defined on a clinical test
- * Participant with a history of cardiovascular disease, defined by a diagnosis of coronary artery disease, peripheral artery disease, or cerebrovascular disease
- * Participant with quantifiable plaque on a coronary computed tomography angiography
- * Participant with a history of Liver disease (cirrhosis, active hepatitis, or severe hepatic disease) or any of the following recent lab results and determined to be non-transient: alanine aminotransferase greater than 3 times the upper limit of normal or total bilirubin greater than 2 times the upper limit of normal (unless due to Gilbert syndrome)
- * Participant with estimated glomerular filtration rate \<60 mL/min/1.73 m2 or creatinine greater than 2 times the upper limit of normal
- * Patient with history of an allergic reaction or significant sensitivity to iodinated contrast, colchicine, or statins
- * Patient currently taking LDL cholesterol lowering or anti- inflammatory medications including colchicine
- * Participants requiring regular drugs known to be potent CY2P inhibitors (eg. ketoconazole, clarithromycin)
- * Female patient who is pregnant, or breast-feeding or is considering becoming pregnant during the study
- * Participant with BMI ≥ 40 kg/m2
- * Participant unable to provide informed consent
- * Participant unable to hold breath for 10 seconds
Ages Eligible for Study
40 Years to 75 Years
Sexes Eligible for Study
ALL
Accepts Healthy Volunteers
No