Omega-3 Fatty Acids as Regulators of Brown Adipose Tissue During Cold Exposure

Description

This clinical trial will assess the whether fish oil supplementation can modulate brown fat activation, shivering, thermal comfort and skin blood flow during cold exposure.

Conditions

Cold Exposure

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Study Overview

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Study Details

Study overview

This clinical trial will assess the whether fish oil supplementation can modulate brown fat activation, shivering, thermal comfort and skin blood flow during cold exposure.

Omega-3 Fatty Acid Modulation of Brown Adipose Tissue for Arctic Resilience

Omega-3 Fatty Acids as Regulators of Brown Adipose Tissue During Cold Exposure

Condition
Cold Exposure
Intervention / Treatment

-

Contacts and Locations

Bloomington

Human Perfromance Lab, Indiana University, Bloomington, Indiana, United States, 47405

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Male and female, between the ages of 18 to 40 years.
  • * Body Mass Index (BMI) of 18.5 to 24.9 kg/m2
  • * Considered "moderately to highly active" by the International Physical Activity Questionnaire (IPAQ) and the Physical Activity Readiness Questionnaire (PAR-Q+)
  • * History of smoking or recreational smoking, hyperlipidemia, hypertension/cardiovascular disease, diabetes, renal disease, neurological disease, metabolic disease, and bleeding disorders or delayed clotting time.
  • * Taking SSRI's (antidepressants and anxiety medication), ADD/ADHD medication, and chronically consume pain medication (Aleve, Tylenol, CBD, etc).
  • * Have or have had chronic disorders of the rectum (e.g., cancer, surgery, active hemorrhoids, etc.) or who currently have related acute conditions (diarrhea, constipation, etc.).
  • * Have or have had a diagnosis of disorders related to immune suppression and/or autoimmune disease.
  • * Are pregnant or planning on being pregnant.
  • * Resting blood pressure of \> 130mmHg systolic or 90 mmHg diastolic.
  • * Resting Pulse rate of \> 100 bpm.
  • * History of regularly consuming fish oil supplements and/or regularly eating more than one fish meal per week.
  • * Consuming more than one fish meal per week during the study.

Ages Eligible for Study

18 Years to 40 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Indiana University,

Timothy D Mickleborough, PhD, PRINCIPAL_INVESTIGATOR, Indiana University

Study Record Dates

2024-12