Fecal Microbiota Transplant for Patients With Chronic Pouchitis

Eligibility Criteria

• * Chronic antibiotic dependent pouchitis: need for continuous antibiotic therapy (\>4 weeks) to maintain clinical remission and a history of at least 2 attempts in the last 24 months to stop antibiotic therapy resulting in pouchitis episodes OR
• * Active pouchitis with a modified Pouchitis Disease Activity Index (mPDAI) ≥5 and a history of ≥4 antibiotic therapies in the last 12 months
• * Allergy to vancomycin, metronidazole, or ingredients present in the FMT
• * Women who are breastfeeding
• * Women who are pregnant
• * Subjects with fever \> 100.4F/38C or other signs of active illness
• * Active treatment with biologics (infliximab, adalimumab, golimumab, vedolizumab, ustekinumab)
• * Active treatment with immunomodulators (azathioprine, 6-mercaptopurine, methotrexate), steroids or any investigational drugs
• * Crohn's disease like pouch inflammation
• * Active enteric infection
• * Isolated cuffitis
• * Clinically significant strictures of the pouch inlet or outlet
• * Participation in a clinical trial in the preceding 30 days
• * Any condition that the physician investigators deems unsafe, including other conditions or medications that the investigator determines will put the subject at greater risk from FMT