RECRUITING

Up-2 Study: Cognitively Engaging Walking Exercise and Neuromodulation to Enhance Brain Function in Older Adults

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Declines in cognitive function and walking function are highly intertwined in older adults. A therapeutic approach that combines complex (cognitively engaging) aerobic walking exercise with non-invasive electrical brain stimulation may be effective at restoring lost function. This study tests whether electrical stimulation of prefrontal brain regions is more beneficial than sham stimulation.

Official Title

Cognitively Engaging Walking Exercise and Neuromodulation to Enhance Brain Function in Older Adults

Quick Facts

Study Start:2024-04-15
Study Completion:2027-04-30
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05830942

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:65 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Age 65+
  2. * Objective executive function decline, based on standardized cognitive assessments.
  3. * Subjective cognitive decline, based on the question: "During the past 12 months, have you experienced confusion or memory loss that is happening more often or getting worse?"
  4. * Ability to walking independently for 6 minutes (use of cane permitted)
  1. * Major cognitive disorder that interferes with independence
  2. * Percentile score less than 10th percentile on standardized cognitive assessments
  3. * Medications that are thought to influence tDCS neuroplasticity.
  4. * Contraindications to tDCS or MRI.

Contacts and Locations

Study Contact

David J Clark, ScD
CONTACT
352-376-1611
davidclark@ufl.edu

Principal Investigator

David J Clark, ScD
PRINCIPAL_INVESTIGATOR
University of Florida

Study Locations (Sites)

University of Florida
Gainesville, Florida, 32610
United States
Brooks Rehabilitation
Jacksonville, Florida, 32653
United States

Collaborators and Investigators

Sponsor: University of Florida

  • David J Clark, ScD, PRINCIPAL_INVESTIGATOR, University of Florida

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-04-15
Study Completion Date2027-04-30

Study Record Updates

Study Start Date2024-04-15
Study Completion Date2027-04-30

Terms related to this study

Additional Relevant MeSH Terms

  • Cognitive Dysfunction
  • Mobility Limitation
  • Frail Elderly