Up-2 Study: Cognitively Engaging Walking Exercise and Neuromodulation to Enhance Brain Function in Older Adults

Description

Declines in cognitive function and walking function are highly intertwined in older adults. A therapeutic approach that combines complex (cognitively engaging) aerobic walking exercise with non-invasive electrical brain stimulation may be effective at restoring lost function. This study tests whether electrical stimulation of prefrontal brain regions is more beneficial than sham stimulation.

Conditions

Cognitive Dysfunction, Mobility Limitation, Frail Elderly

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Study Overview

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Study Details

Study overview

Declines in cognitive function and walking function are highly intertwined in older adults. A therapeutic approach that combines complex (cognitively engaging) aerobic walking exercise with non-invasive electrical brain stimulation may be effective at restoring lost function. This study tests whether electrical stimulation of prefrontal brain regions is more beneficial than sham stimulation.

Cognitively Engaging Walking Exercise and Neuromodulation to Enhance Brain Function in Older Adults

Up-2 Study: Cognitively Engaging Walking Exercise and Neuromodulation to Enhance Brain Function in Older Adults

Condition
Cognitive Dysfunction
Intervention / Treatment

-

Contacts and Locations

Gainesville

University of Florida, Gainesville, Florida, United States, 32610

Jacksonville

Brooks Rehabilitation, Jacksonville, Florida, United States, 32653

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age 65+
  • * Objective executive function decline, based on standardized cognitive assessments.
  • * Subjective cognitive decline, based on the question: "During the past 12 months, have you experienced confusion or memory loss that is happening more often or getting worse?"
  • * Ability to walking independently for 6 minutes (use of cane permitted)
  • * Major cognitive disorder that interferes with independence
  • * Percentile score less than 10th percentile on standardized cognitive assessments
  • * Medications that are thought to influence tDCS neuroplasticity.
  • * Contraindications to tDCS or MRI.

Ages Eligible for Study

65 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Florida,

David J Clark, ScD, PRINCIPAL_INVESTIGATOR, University of Florida

Study Record Dates

2027-04-30