COMPLETED

Testing the Effect of ENDS Flavors on Neurotransmission

Conditions

Tobacco Dependence Tobacco Nicotine Smoking Addiction

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The overarching goal of this translational proposal is to determine if neuroactive flavor chemicals can enhance the addiction potential of electronic nicotine delivery systems (ENDS) by altering brain function and behavior.

Official Title

Testing the Effect of ENDS Flavors on Neurotransmission

Quick Facts

Study Start:2023-06-01

Study Completion:2025-07-31

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:COMPLETED

Study ID

NCT05836051

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:21 Years to 60 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:No

Standard Ages:ADULT

Inclusion Criteria	Exclusion Criteria
1. 21 to 60 years old 2. Regular users of inhaled tobacco products (≥5 days out of the last 28) 3. Not planning to quit tobacco use within next month 4. Able to read and write in English	1. Major neurological conditions or brain trauma 2. Current substance use impairing participation 3. Unstable or significant medical conditions (e.g., COPD, coronary heart disease) 4. Current use of smoking cessation medication (e.g., varenicline, patch) 5. Uncontrolled serious mental illness, suicidality, or inpatient psychiatric hospitalization in the past 6 months 6. Known allergic reaction to ENDS liquids ingredients propylene glycol or vegetable glycerin 7. Unable to use study provided ENDS ad-libitum for at least 3 hours per day 8. Pregnant or breastfeeding as indicated by self-report or urine pregnancy screen

Inclusion Criteria

Exclusion Criteria

1. 21 to 60 years old
2. Regular users of inhaled tobacco products (≥5 days out of the last 28)
3. Not planning to quit tobacco use within next month
4. Able to read and write in English

1. Major neurological conditions or brain trauma
2. Current substance use impairing participation
3. Unstable or significant medical conditions (e.g., COPD, coronary heart disease)
4. Current use of smoking cessation medication (e.g., varenicline, patch)
5. Uncontrolled serious mental illness, suicidality, or inpatient psychiatric hospitalization in the past 6 months
6. Known allergic reaction to ENDS liquids ingredients propylene glycol or vegetable glycerin
7. Unable to use study provided ENDS ad-libitum for at least 3 hours per day
8. Pregnant or breastfeeding as indicated by self-report or urine pregnancy screen

Contacts and Locations

Study Locations (Sites)

Penn State Health

Hershey, Pennsylvania, 17033

United States

Collaborators and Investigators

Sponsor: Milton S. Hershey Medical Center

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-06-01

Study Completion Date2025-07-31

Study Record Updates

Study Start Date2023-06-01

Study Completion Date2025-07-31

Terms related to this study

Keywords Provided by Researchers

Tobacco
Nicotine
Smoking
Addiction

Additional Relevant MeSH Terms

Tobacco Dependence