Testing the Effect of ENDS Flavors on Neurotransmission

Description

The overarching goal of this translational proposal is to determine if neuroactive flavor chemicals can enhance the addiction potential of electronic nicotine delivery systems (ENDS) by altering brain function and behavior.

Conditions

Tobacco Dependence

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Study Overview

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Study Details

Study overview

The overarching goal of this translational proposal is to determine if neuroactive flavor chemicals can enhance the addiction potential of electronic nicotine delivery systems (ENDS) by altering brain function and behavior.

Testing the Effect of ENDS Flavors on Neurotransmission

Testing the Effect of ENDS Flavors on Neurotransmission

Condition
Tobacco Dependence
Intervention / Treatment

-

Contacts and Locations

Hershey

Penn State Health, Hershey, Pennsylvania, United States, 17033

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. 21 to 60 years old
  • 2. Regular users of inhaled tobacco products (≥5 days out of the last 28)
  • 3. Not planning to quit tobacco use within next month
  • 4. Able to read and write in English
  • 1. Major neurological conditions or brain trauma
  • 2. Current substance use impairing participation
  • 3. Unstable or significant medical conditions (e.g., COPD, coronary heart disease)
  • 4. Current use of smoking cessation medication (e.g., varenicline, patch)
  • 5. Uncontrolled serious mental illness, suicidality, or inpatient psychiatric hospitalization in the past 6 months
  • 6. Known allergic reaction to ENDS liquids ingredients propylene glycol or vegetable glycerin
  • 7. Unable to use study provided ENDS ad-libitum for at least 3 hours per day
  • 8. Pregnant or breastfeeding as indicated by self-report or urine pregnancy screen

Ages Eligible for Study

21 Years to 60 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Milton S. Hershey Medical Center,

Study Record Dates

2025-12-31