RECRUITING

Trifecta-Lung cfDNA-MMDx Study

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Demonstrate the relationship between dd-cfDNA levels and HLA antibodies in blood transplant recipient and Demonstrate the Molecular Microscope® (MMDx) Diagnostic System results in indication and protocol biopsies from lung transplants.

Official Title

Trifecta-Lung cfDNA-MMDx Study: Comparing the Dd-cfDNA Test to MMDx Microarray Test and Central HLA Antibody Test

Quick Facts

Study Start:2023-11-01
Study Completion:2027-12
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05837663

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Not specified
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. Age 18 years or older
  2. Willing and able to provide informed consent
  3. Able to understand and follow study procedures
  4. Stable medical condition
  1. Pregnancy or breastfeeding
  2. Severe psychiatric disorders
  3. Active substance abuse
  4. Unstable medical conditions
  5. Inability to comply with study requirements

Contacts and Locations

Study Contact

Konrad S Famulski, PhD DSc
CONTACT
1 780 782 9463
konrad@ualberta.ca
Robert Polakowski, PhD
CONTACT
1 780 492 5091
polakows@ualberta.ca

Principal Investigator

Philip F Halloran, MD PhD
PRINCIPAL_INVESTIGATOR
Alberta Transplant Applied Genomics Centre, University of Alberta

Study Locations (Sites)

Division of Pulmonary, Critical Care and Sleep Medicine, University of Florida, College of Medicine
Gainesville, Florida, 32610
United States
BAYLOR SCOTT & WHITE RESEARCH INSTITUTE , 3409 Worth Street
Dallas, Texas, 75246
United States

Collaborators and Investigators

Sponsor: University of Alberta

  • Philip F Halloran, MD PhD, PRINCIPAL_INVESTIGATOR, Alberta Transplant Applied Genomics Centre, University of Alberta

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-11-01
Study Completion Date2027-12

Study Record Updates

Study Start Date2023-11-01
Study Completion Date2027-12

Terms related to this study

Keywords Provided by Researchers

  • Donor derived cfDNA
  • Gene expression
  • Lung transplant biopsy
  • Blood

Additional Relevant MeSH Terms

  • Lung Transplantation