RECRUITING

Quality of Life Assessment of Radiotherapy in Recurrent Head and Neck Cancer

Conditions

Head and Neck Cancer Radiation Therapy Mobile Health QUADSHOT Quality of Life

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this study is to examine the uses of a mobile health-based assessment and symptom monitoring platform.

Official Title

Quality of Life Assessment of Hypofractionated Radiotherapy in Recurrent Head and Neck Cancer: CPC-CT Pilot

Quick Facts

Study Start:2024-11-30

Study Completion:2026-08-30

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:RECRUITING

Study ID

NCT05850663

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:No

Standard Ages:ADULT, OLDER_ADULT

Inclusion Criteria	Exclusion Criteria
* Age 18 years and older * Written informed consent and any locally-required authorization obtained from the patients prior to performing any protocol-related procedures, including screening evaluations * Pathologically (histologically or cytologically) proven diagnosis of cancer of the head and neck (nasopharynx, oral cavity, oropharynx, hypopharynx, larynx, or unknown primary) * Locally recurrent or metastatic HNC not deemed amenable to curative-intent salvage therapy, in whom at least six months have passed since their prior RT, if received * Must have evaluable lesion per RECIST v1.1 * Patients agree to provide their smoking history prior to registration * ECOG performance status of 0-2	* Prior radiotherapy to the region of the study cancer within less than 6 months * Patients who have received prior radiation therapy and who, in the opinion of the treating radiation oncologist, cannot be reirradiated safely without excess risk of severe toxicity given prior radiation dose to critical structures. * Patients with known contraindications to radiotherapy, including inherited syndromes associated with hypersensitivity to ionizing radiation (e.g., Ataxia-Telangiectasia, Nijmegen Breakage Syndrome) * Female patients who are pregnant

Inclusion Criteria

Exclusion Criteria

* Age 18 years and older
* Written informed consent and any locally-required authorization obtained from the patients prior to performing any protocol-related procedures, including screening evaluations
* Pathologically (histologically or cytologically) proven diagnosis of cancer of the head and neck (nasopharynx, oral cavity, oropharynx, hypopharynx, larynx, or unknown primary)
* Locally recurrent or metastatic HNC not deemed amenable to curative-intent salvage therapy, in whom at least six months have passed since their prior RT, if received
* Must have evaluable lesion per RECIST v1.1
* Patients agree to provide their smoking history prior to registration
* ECOG performance status of 0-2

* Prior radiotherapy to the region of the study cancer within less than 6 months
* Patients who have received prior radiation therapy and who, in the opinion of the treating radiation oncologist, cannot be reirradiated safely without excess risk of severe toxicity given prior radiation dose to critical structures.
* Patients with known contraindications to radiotherapy, including inherited syndromes associated with hypersensitivity to ionizing radiation (e.g., Ataxia-Telangiectasia, Nijmegen Breakage Syndrome)
* Female patients who are pregnant

Contacts and Locations

Study Contact

SCC IIT Office

CONTACT

1-405-271-8777

SCC-IIT-Office@ouhsc.edu

Study Locations (Sites)

Stephenson Cancer Center

Oklahoma City, Oklahoma, 73104

United States

Collaborators and Investigators

Sponsor: University of Oklahoma

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-11-30

Study Completion Date2026-08-30

Study Record Updates

Study Start Date2024-11-30

Study Completion Date2026-08-30

Terms related to this study

Keywords Provided by Researchers

Radiation Therapy
Mobile Health
QUADSHOT
Quality of Life

Additional Relevant MeSH Terms

Head and Neck Cancer