Disentangling the Role of Depression in Hypersomnia

Description

Individuals who have disorders of hypersomnolence (excessive sleepiness) often report symptoms of depression. The goal of this study is to further understand of the relationship between depression and hypersomnia by examining mood-relevant domains of slow wave sleep and reward function.

Conditions

Hypersomnia

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Study Overview

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Study Details

Study overview

Individuals who have disorders of hypersomnolence (excessive sleepiness) often report symptoms of depression. The goal of this study is to further understand of the relationship between depression and hypersomnia by examining mood-relevant domains of slow wave sleep and reward function.

Disentangling the Role of Depression in Hypersomnia

Disentangling the Role of Depression in Hypersomnia

Condition
Hypersomnia
Intervention / Treatment

-

Contacts and Locations

Philadelphia

The University of Pennsylvania, Philadelphia, Pennsylvania, United States, 19104

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Males and females between the age of 21 and 55
  • * Meet DSM5 criteria for Idiopathic Hypersomnia or Hypersomnia Associated with a Psychiatry Disorder
  • * Ability to read and speak English
  • * Unable or unwilling to provide informed consent
  • * Untreated obstructive sleep apnea (apnea-hypopnea index /= 15 events/hr)
  • * Meeting diagnostic criteria for narcolepsy
  • * A clinically unstable medical condition as defined by a new diagnosis or change in medical management in the previous 2 months (e.g., pneumonia, thyroid disease, ventricular arrhythmias, cirrhosis, surgery, or recently diagnosed cancer) because these changes could impact daytime hypersomnia and confound results
  • * Substance abuse/dependence, delirium, dementia, amnestic disorder, schizophrenia, and other psychotic disorders
  • * Prominent current suicidal or homicidal ideation.
  • * Unable to perform tests due to inability to communicate verbally, inability to read and write; less than a 5th grade reading level; visal, hearing, or cognitive impairment (e.g. previous head injury)
  • * Use of medications or OTC products that might impact sleep

Ages Eligible for Study

21 Years to 55 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Pennsylvania,

Philip Gehrman, PhD, PRINCIPAL_INVESTIGATOR, University of Pennsylvania

Study Record Dates

2025-06-30