Liquid Biopsy Based NGS in Newly Diagnosed NSCLC

Description

This study expands the application of an electronic health record (EHR) "nudge" used to prompt physicians' clinical practice to order molecular testing at the time of initial diagnosis for patients with specific types of advanced lung cancer. The primary goal is to have these test results available prior to starting treatment so that physicians can make molecularly-informed treatment decisions. The second goal is to better understand factors that contribute to whether or not the EHR-nudge implementation is successful.

Conditions

Non Small Cell Lung Cancer Metastatic, Newly Diagnosed NSCLC, Non-Squamous Non-Small Cell Neoplasm of Lung

Study Overview

Study Details

Study overview

This study expands the application of an electronic health record (EHR) "nudge" used to prompt physicians' clinical practice to order molecular testing at the time of initial diagnosis for patients with specific types of advanced lung cancer. The primary goal is to have these test results available prior to starting treatment so that physicians can make molecularly-informed treatment decisions. The second goal is to better understand factors that contribute to whether or not the EHR-nudge implementation is successful.

iNUDGE: INtegration of liqUiD Biopsy Based Next Generation Gene sEquencing in Newly Diagnosed NSCLC - A Stepped Wedge Cluster Randomized Clinical Trial

Liquid Biopsy Based NGS in Newly Diagnosed NSCLC

Condition
Non Small Cell Lung Cancer Metastatic
Intervention / Treatment

-

Contacts and Locations

Cherry Hill

Penn Medicine Cherry Hill, Cherry Hill, New Jersey, United States, 08003

Plainsboro

Penn Medicine Princeton Health, Plainsboro, New Jersey, United States, 08536

Sewell

Penn Medicine Washington Township, Sewell, New Jersey, United States, 08080

Voorhees

Penn Medicine Voorhees, Voorhees, New Jersey, United States, 08043

Lancaster

Penn Medicine Lancaster General Health, Lancaster, Pennsylvania, United States, 17602

Philadelphia

Penn Presbyterian Medical Center, Philadelphia, Pennsylvania, United States, 19104

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Participants with a histological, or cytological diagnosis of metastatic non-squamous (mNSq) non-small cell lung cancer (NSCLC) who have not yet received systemic treatment for metastatic disease.
  • * Participants must be seen at Lancaster General Health (LGH), Penn Presbyterian Medical Center (PPMC), Penn Medicine Cherry Hill (PMCH), Penn Medicine Princeton Health (PMPH), Penn Medicine Voorhees (PMV) or Penn Medicine Washington Township (PMWT) for mNSq NSCLC.
  • * Participants with incomplete staging information.
  • * Children, pregnant women, fetuses, neonates, or prisoners are not included in this research study.

Ages Eligible for Study

to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Charu Aggarwal,

Charu Aggarwal, MD, MPH, PRINCIPAL_INVESTIGATOR, Penn Medicine

Study Record Dates

2025-12