RECRUITING

Reversal of Battle-Related Aging (ROBRA) in a Special Operations Forces Cohort

Conditions

Post-Traumatic Stress Disorder Traumatic Brain Injury

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this study is to examine measures of GrimAge clock in SOF members undergoing treatment for PTSD/TBI using CSB.

Official Title

Reversal of Battle-Related Aging (ROBRA) in a Special Operations Forces Cohort

Quick Facts

Study Start:2023-07-05

Study Completion:2024-04-05

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:RECRUITING

Study ID

NCT05855876

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:40 Years to 60 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:No

Standard Ages:ADULT

Inclusion Criteria	Exclusion Criteria
* Recruited from SOF with an active duty history of at least 5 years. * Subjects may be in active duty or retired, male and female, between the ages of 40 and 60 years old. * The participants must have a confirmed diagnosis of PTSD, identified by Posttraumatic Stress Disorder Checklist for DSM-5 (PCL-5) scores higher than 40. * The participants must have been on a stable pharmacological or psychotherapeutic therapy for at least three months (if applicable), and continue this treatment throughout the duration of the study. * They must be able and willing to consent for the study. Individuals who are able to become pregnant must adhere to a medically accepted method of contraception (eg. hormonal birth control, barrier birth control, intrauterine device, abstinence).	* Existing Horner syndrome; * Allergy to local anesthetics or contrast; * Previous history of stellate ganglion block with psychosis; * Admission to in-patient psychiatric facility within last 3 months; * History of moderate of severe TBI; * Currently pregnant or breastfeeding; * Current substance use disorder, or test positive for 1 or more illegal or controlled drugs on the initial urine drug screen, such as cocaine, marijuana, amphetamines, opioids, benzodiazepines, amongst others; * Previous behavioral health diagnoses (bipolar I, psychosis, etc); * Currently undergoing exposure therapy.

Inclusion Criteria

Exclusion Criteria

* Recruited from SOF with an active duty history of at least 5 years.
* Subjects may be in active duty or retired, male and female, between the ages of 40 and 60 years old.
* The participants must have a confirmed diagnosis of PTSD, identified by Posttraumatic Stress Disorder Checklist for DSM-5 (PCL-5) scores higher than 40.
* The participants must have been on a stable pharmacological or psychotherapeutic therapy for at least three months (if applicable), and continue this treatment throughout the duration of the study.
* They must be able and willing to consent for the study. Individuals who are able to become pregnant must adhere to a medically accepted method of contraception (eg. hormonal birth control, barrier birth control, intrauterine device, abstinence).

* Existing Horner syndrome;
* Allergy to local anesthetics or contrast;
* Previous history of stellate ganglion block with psychosis;
* Admission to in-patient psychiatric facility within last 3 months;
* History of moderate of severe TBI;
* Currently pregnant or breastfeeding;
* Current substance use disorder, or test positive for 1 or more illegal or controlled drugs on the initial urine drug screen, such as cocaine, marijuana, amphetamines, opioids, benzodiazepines, amongst others;
* Previous behavioral health diagnoses (bipolar I, psychosis, etc);
* Currently undergoing exposure therapy.

Contacts and Locations

Principal Investigator

Eugene Lipov, MD

PRINCIPAL_INVESTIGATOR

Stella Center

Study Locations (Sites)

Stella Center

Westmont, Illinois, 60656

United States

Collaborators and Investigators

Sponsor: Stella Center

Eugene Lipov, MD, PRINCIPAL_INVESTIGATOR, Stella Center

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-07-05

Study Completion Date2024-04-05

Study Record Updates

Study Start Date2023-07-05

Study Completion Date2024-04-05

Terms related to this study

Additional Relevant MeSH Terms

Post-Traumatic Stress Disorder
Traumatic Brain Injury