Exercise Response in Humans With Obesity

Description

This study is being done to understand how chronic inflammation affects muscle function and responses to exercise.

Conditions

Obese

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Study Overview

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Study Details

Study overview

This study is being done to understand how chronic inflammation affects muscle function and responses to exercise.

Exercise Response in Humans With Obesity

Exercise Response in Humans With Obesity

Condition
Obese
Intervention / Treatment

-

Contacts and Locations

Rochester

Mayo Clinic in Rochester, Rochester, Minnesota, United States, 55905

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Obese men and women ≥ 20 and ≤ 45 years of age.
  • * Diabetes or fasting plasma glucose \>126 mg/dL
  • * Anemia (female subjects hemoglobin of \<11 g/dl and male subjects hemoglobin \<12 g/dl)
  • * Active coronary artery disease or history of unstable macrovascular disease (unstable angina, myocardial infarction, stroke, and revascularization of coronary, peripheral or carotid artery within 3 months of recruitment)
  • * Renal failure (serum creatinine \> 1.5mg/dl)
  • * Chronic active liver disease defined as aspartate aminotransferase (AST)\>144 IU/L or alanine transaminase (ALT) \>165 IU/L)
  • * Oral warfarin group medications or history of blood clotting disorders.
  • * Smoking
  • * Pregnancy or breastfeeding
  • * Alcohol consumption greater than 2 glasses/day or other substance abuse
  • * Untreated or uncontrolled hypothyroidism
  • * Debilitating chronic disease (at the discretion of the investigators)

Ages Eligible for Study

20 Years to 45 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Mayo Clinic,

Ian Lanza, PhD, PRINCIPAL_INVESTIGATOR, Mayo Clinic

Study Record Dates

2029-07