Low-Intensity Focused Ultrasound for Cocaine Use Disorder

Description

This study aims to understand the role of Low-Intensity Focused Ultrasound on craving levels for cocaine as evidenced by diagnostic imaging of the dorsal anterior insula (dAI) and subjective ratings. Data analysis will serve to show if 1) LIFU is safe and effective and to 2) examine the effects of LIFU on dAI BOLD activity and craving in response to cocaine cue-exposure. The study will screen 60 individuals with Cocaine Use Disorder (CUD) to arrive at 30 enrolled subjects, based on a 2:1 screen/randomization ratio.

Conditions

Cocaine Use Disorder, Cocaine Dependence, Cocaine Abuse, Ultrasound

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Study Overview

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Study Details

Study overview

This study aims to understand the role of Low-Intensity Focused Ultrasound on craving levels for cocaine as evidenced by diagnostic imaging of the dorsal anterior insula (dAI) and subjective ratings. Data analysis will serve to show if 1) LIFU is safe and effective and to 2) examine the effects of LIFU on dAI BOLD activity and craving in response to cocaine cue-exposure. The study will screen 60 individuals with Cocaine Use Disorder (CUD) to arrive at 30 enrolled subjects, based on a 2:1 screen/randomization ratio.

Low-Intensity Focused Ultrasound for Cocaine Use Disorder

Low-Intensity Focused Ultrasound for Cocaine Use Disorder

Condition
Cocaine Use Disorder
Intervention / Treatment

-

Contacts and Locations

Charlottesville

UVA Center for Leading Edge Addiction Research, Charlottesville, Virginia, United States, 22903

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Ages 18 years and older with a history of cocaine use disorder
  • * Have a current (past 6 months) DSM-5 diagnosis of cocaine use disorder (4 or more symptoms) assessed using the MINI neuropsychiatric interview
  • * Have a blood alcohol content by breathalyzer, equal to 0.000 when informed consent document is signed
  • * Ability to abstain from cocaine use at key points during study
  • * Willingness and ability to comply with scheduled visits and study procedures
  • * Ability to lie down for extended periods of time for imaging tests
  • * Will have reliable transportation throughout study
  • * Will have a stable residence during the 2 weeks prior to randomization and not be at risk of losing housing in next 2 months
  • * Must meet criteria to have magnetic resonance imaging (MRI)

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

University of Virginia,

Nassima Ait-Daoud Tiouririne, MD, PRINCIPAL_INVESTIGATOR, University of Virginia, Center for Leading Edge Addiction Research

Study Record Dates

2025-03-01