TERMINATED

A Phase 1 Study of ZL-1218 in Subjects With Advanced Solid Tumors

Conditions

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of this study is to characterize the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary antitumor activity of ZL-1218 as a single agent and as combination therapy in subjects with advanced solid tumor malignancies.

Official Title

A Phase I, Open-label, Multicenter Study of ZL-1218 as a Single Agent and as Combination Therapy With Anti-PD-1 Antibody to Evaluate the Safety, Tolerability, and Pharmacokinetics in Subjects With Advanced Solid Tumor Malignancies

Quick Facts

Study Start:2023-07-24

Study Completion:2025-08-28

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:TERMINATED

Study ID

NCT05859464

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:No

Standard Ages:ADULT, OLDER_ADULT

Inclusion Criteria	Exclusion Criteria
* Adult men and women ≥ 18 years of age. If 18 years is not the age of majority, then adult men and women ≥ age of majority per local regulation. * Eastern Cooperative Oncology Group (ECOG) performance status of 0-1. * Life expectancy \> 12 weeks. * Subjects must have histologically confirmed and documented diagnosis of locally advanced unresectable or metastatic advanced solid tumor that is refractory to standard treatment, or intolerant to standard treatment, or for which no standard treatment exists.Subjects must have at least one target lesion as defined by RECIST v1.1 on CT, PET/CT, or MRI scan. * Subjects must have a site of disease which is not previously irradiated and is safe and amenable to biopsy per the treating institution's guidelines. Subjects must be willing to undergo a tumor biopsy at screening and on treatment, per the protocol guidelines. * Subjects must have a site of disease which is not previously irradiated and is safe and amenable to biopsy per the treating institution's guidelines. Subjects must be willing to undergo a tumor biopsy at screening and on treatment, per the protocol guidelines.	* Symptomatic or uncontrolled brain metastasis requiring concurrent treatment, inclusive of but not limited to surgery, radiation, and/or corticosteroids. * Prior exposure to CCR8 inhibitor (anti-CCR8 antibody) or hypersensitivity to any ingredient of the study drug. * Out of range value within 10 days prior to the first dose of study treatment. * Subjects have received a live or live-attenuated vaccine within 30 days of planned start of study therapy. * Subjects with known history of, or any evidence of active, non-infectious pneumonitis. * Impaired cardiac function or clinically significant cardiac disease within the last 3 months before administration of the first dose of the study drug. * Treatment with any systemic anti-cancer treatment (including investigational products) within 4 weeks before first dose of study drug. * Non-palliative radiotherapy within 2 weeks prior to first dose of study drug or have had history of radiation pneumonitis. * Major surgery within 4 weeks of the first dose of study drug. * Infections requiring systemic antibiotic therapy. * Any medical conditions that would, in the investigator's judgement, prevent the subject's participation in the clinical study due to safety concerns, compliance with the study procedures, or interpretation of the study results.

Inclusion Criteria

Exclusion Criteria

* Adult men and women ≥ 18 years of age. If 18 years is not the age of majority, then adult men and women ≥ age of majority per local regulation.
* Eastern Cooperative Oncology Group (ECOG) performance status of 0-1.
* Life expectancy \> 12 weeks.
* Subjects must have histologically confirmed and documented diagnosis of locally advanced unresectable or metastatic advanced solid tumor that is refractory to standard treatment, or intolerant to standard treatment, or for which no standard treatment exists.Subjects must have at least one target lesion as defined by RECIST v1.1 on CT, PET/CT, or MRI scan.
* Subjects must have a site of disease which is not previously irradiated and is safe and amenable to biopsy per the treating institution's guidelines. Subjects must be willing to undergo a tumor biopsy at screening and on treatment, per the protocol guidelines.
* Subjects must have a site of disease which is not previously irradiated and is safe and amenable to biopsy per the treating institution's guidelines. Subjects must be willing to undergo a tumor biopsy at screening and on treatment, per the protocol guidelines.

* Symptomatic or uncontrolled brain metastasis requiring concurrent treatment, inclusive of but not limited to surgery, radiation, and/or corticosteroids.
* Prior exposure to CCR8 inhibitor (anti-CCR8 antibody) or hypersensitivity to any ingredient of the study drug.
* Out of range value within 10 days prior to the first dose of study treatment.
* Subjects have received a live or live-attenuated vaccine within 30 days of planned start of study therapy.
* Subjects with known history of, or any evidence of active, non-infectious pneumonitis.
* Impaired cardiac function or clinically significant cardiac disease within the last 3 months before administration of the first dose of the study drug.
* Treatment with any systemic anti-cancer treatment (including investigational products) within 4 weeks before first dose of study drug.
* Non-palliative radiotherapy within 2 weeks prior to first dose of study drug or have had history of radiation pneumonitis.
* Major surgery within 4 weeks of the first dose of study drug.
* Infections requiring systemic antibiotic therapy.
* Any medical conditions that would, in the investigator's judgement, prevent the subject's participation in the clinical study due to safety concerns, compliance with the study procedures, or interpretation of the study results.

Contacts and Locations

Study Locations (Sites)

Zai Lab Site 2005

Irvine, California, 92618

United States

Zai Lab Site 2007

Detroit, Michigan, 48201

United States

Zai Lab Site 2001

Hackensack, New Jersey, 07601

United States

Zai Lab Site 2002

New York, New York, 10029

United States

Zai Lab Site 2003

Spokane, Washington, 99208

United States

Collaborators and Investigators

Sponsor: Zai Lab (Hong Kong), Ltd.

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-07-24

Study Completion Date2025-08-28

Study Record Updates

Study Start Date2023-07-24

Study Completion Date2025-08-28

Terms related to this study

Additional Relevant MeSH Terms

Malignant Solid Tumor