Ventilation and Esophageal Pressure Changes

Description

A study to observe the effect of variations in ventilator settings including tidal volume and PEEP on transpulmonary pressure monitored with an esophageal balloon catheter and to correlate intraoperative transpulmonary pressure variations and intraoperative stroke volume variation changes.

Conditions

Mechanical Ventilation

Study Overview

Study Details

Study overview

A study to observe the effect of variations in ventilator settings including tidal volume and PEEP on transpulmonary pressure monitored with an esophageal balloon catheter and to correlate intraoperative transpulmonary pressure variations and intraoperative stroke volume variation changes.

A Study of Intraoperative Transpulmonary and Intrathoracic Pressure Changes Associated With Ventilator Management of Tidal Volume and Positive End-expiratory Pressure (PEEP)

Ventilation and Esophageal Pressure Changes

Condition
Mechanical Ventilation
Intervention / Treatment

-

Contacts and Locations

Sacramento

UC Davis Medical Center, Sacramento, California, United States, 95817

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Patients scheduled for elective surgery requiring general anesthesia and endotracheal intubation.
  • * Age ≥ 18
  • * Patients undergoing planned esophageal surgery
  • * Patients with significant nasal or esophageal pathology
  • * Adults unable to consent
  • * Individuals who are not yet adults (infants, children, teenagers)
  • * Pregnant women
  • * Prisoners

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of California, Davis,

Neal Fleming, MD, PhD, PRINCIPAL_INVESTIGATOR, University of California, Davis

Study Record Dates

2025-01