RECRUITING

PAI-1, tPA, TFPI and HEECs in Uterine Hemostasis

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The purpose of the study is to learn more about the role of blood clotting factor proteins and cells in menstrual (period) bleeding. The investigators are hoping to identify differences in these proteins and cells in the menstrual blood of individuals with heavy periods compared to menstruating individuals who do not have heavy periods.

Official Title

The Role of Plasminogen Activator Inhibitor-1 (PAI-1), Tissue Plasminogen Activator (tPA), Tissue Factor Pathway Inhibitor (TFPI), and Endometrial Endothelial Cells in Uterine Hemostasis in Humans

Quick Facts

Study Start:2023-07-12
Study Completion:2026-07
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05862805

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 45 Years
Sexes Eligible for Study:FEMALE
Accepts Healthy Volunteers:Yes
Standard Ages:ADULT
Inclusion CriteriaExclusion Criteria
  1. * Regularly menstruating participants between 18-45 years of age
  1. * Pregnancy within 3 months of enrollment
  2. * Lactating at the time of enrollment
  3. * Hormonal contraceptive use or use of the copper intrauterine device (IUD)
  4. * Antifibrinolytic use
  5. * Inherited or acquired bleeding disorder or anticoagulant use
  6. * Known structural cause of HMB
  7. * Inability to complete PBACs
  8. * Unwilling to refrain from sexual intercourse for the two weeks prior to endometrial biopsy

Contacts and Locations

Study Contact

Women's Health Research Unit Department of Ob/Gyn
CONTACT
503-494-3666
whru@ohsu.edu

Study Locations (Sites)

OHSU
Portland, Oregon, 97239
United States

Collaborators and Investigators

Sponsor: Oregon Health and Science University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-07-12
Study Completion Date2026-07

Study Record Updates

Study Start Date2023-07-12
Study Completion Date2026-07

Terms related to this study

Additional Relevant MeSH Terms

  • Menstrual Bleeding, Heavy