ACTIVE_NOT_RECRUITING

Brain Blood Flow Responses During Exercise

Conditions

Cerebrovascular Circulation Magnetic Resonance Imaging Exercise Brain Blood Flow

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Brain blood flow will be measured during exercise using magnetic resonance imaging.

Official Title

Influence of Biological Sex and Age on Cerebral Blood Flow and Vessel Function During Exercise: a Pilot Study

Quick Facts

Study Start:2024-03-06

Study Completion:2025-07

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:ACTIVE_NOT_RECRUITING

Study ID

NCT05864950

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:55 Years to 69 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:Yes

Standard Ages:ADULT, OLDER_ADULT

Inclusion Criteria	Exclusion Criteria
* Healthy men or women between the ages of 55-69 years * Demonstrate an exercise history of engaging in aerobic physical activity at least 3 times per week for a minimum of 30 continuous minutes * Have experience using cardiovascular exercise equipment (e.g., treadmill, elliptical, upright or recumbent bicycle, stair-stepper)	* Outside of specified age range * Do not have experience using cardiovascular exercise equipment * Do not meet the physical activity criteria * Present with a history or evidence of hepatic, renal, hematological disease, cardiovascular disease including uncontrolled hypertension, peripheral vascular disease, stroke/neurovascular disease, and diabetes * have a body mass index ≥35 kg/m2 * are ≥ 71 inches (180 cm) in height * have any contraindications to MRI * currently use or have a history of use of tobacco or illegal substances * have current and/or a history of depression or other mood related disorders (those with mild depression and/or anxiety that is controlled with medication and/or therapy will not be excluded) * vulnerable populations (e.g., pregnant women, prisoners, individuals lacking capacity to consent) * if the desired moderate/vigorous exercise intensity corresponds to \> 350 watts on the stepper device

Inclusion Criteria

Exclusion Criteria

* Healthy men or women between the ages of 55-69 years
* Demonstrate an exercise history of engaging in aerobic physical activity at least 3 times per week for a minimum of 30 continuous minutes
* Have experience using cardiovascular exercise equipment (e.g., treadmill, elliptical, upright or recumbent bicycle, stair-stepper)

* Outside of specified age range
* Do not have experience using cardiovascular exercise equipment
* Do not meet the physical activity criteria
* Present with a history or evidence of hepatic, renal, hematological disease, cardiovascular disease including uncontrolled hypertension, peripheral vascular disease, stroke/neurovascular disease, and diabetes
* have a body mass index ≥35 kg/m2
* are ≥ 71 inches (180 cm) in height
* have any contraindications to MRI
* currently use or have a history of use of tobacco or illegal substances
* have current and/or a history of depression or other mood related disorders (those with mild depression and/or anxiety that is controlled with medication and/or therapy will not be excluded)
* vulnerable populations (e.g., pregnant women, prisoners, individuals lacking capacity to consent)
* if the desired moderate/vigorous exercise intensity corresponds to \> 350 watts on the stepper device

Contacts and Locations

Principal Investigator

Jill N Barnes, PhD

PRINCIPAL_INVESTIGATOR

University of Wisconsin, Madison

Study Locations (Sites)

University of Wisconsin-Madison

Madison, Wisconsin, 53706

United States

Collaborators and Investigators

Sponsor: University of Wisconsin, Madison

Jill N Barnes, PhD, PRINCIPAL_INVESTIGATOR, University of Wisconsin, Madison

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2024-03-06

Study Completion Date2025-07

Study Record Updates

Study Start Date2024-03-06

Study Completion Date2025-07

Terms related to this study

Keywords Provided by Researchers

Magnetic Resonance Imaging
Exercise
Brain Blood Flow

Additional Relevant MeSH Terms

Cerebrovascular Circulation
Magnetic Resonance Imaging