RECRUITING

Using Indoor Air Filtration to Slow Atherothrombosis Progression in Adults With Ischemic Heart Disease History

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Conditions

Air PollutionAtherosclerosisParticulate matterAir purifierHEPA filterIschemic Heart DiseaseThrombosisCardiovascular Disease

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

This double-blind, randomized, crossover trial aims to test the hypothesis that longer-term indoor air filtration intervention can slow atherothrombosis progression by reducing indoor fine particulate matter (PM2.5) exposure in adults with ischemic heart disease history.

Official Title

Slowing Atherothrombosis Progression Through Indoor Air Filtration: A Crossover Trial in Hispanic and Non-Hispanic Adults With Ischemic Heart Disease History

Quick Facts

Study Start:2023-07-11
Study Completion:2027-06-30
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05867381

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:65 Years to 84 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:No
Standard Ages:OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Age between 65 and 84 years old;
  2. * Weight ≥ 110 pounds;
  3. * Nonsmokers for at least 1 year;
  4. * Have ischemic heart disease history, clinically stable for 6 months, without any deterioration in symptoms or episodes of angina based on past electronic medical records;
  5. * Both English and Spanish speaking participants will be included in the recruitment;
  6. * Live in the Los Angeles County.
  1. * Have history of degenerative disease of the nervous system such as dementia and Alzheimer's;
  2. * Currently have active cancer treatments;
  3. * The residential house has already had HEPA filters;
  4. * Participants will move out from the current residential address in the next 2 years;
  5. * Participants will spend more than 1 month living outside the primary home;
  6. * Have any health conditions that prohibit collecting health and covariate data and biospecimens;
  7. * Participants' residential houses are not feasible for setting up air purifiers and air pollutants monitors.

Contacts and Locations

Study Contact

Zhanghua Chen, PhD
CONTACT
323-442-2109
zhanghuc@usc.edu
Junfeng Zhang, PhD
CONTACT
919-681-7782
junfeng.zhang@duke.edu

Principal Investigator

Zhanghua Chen, PhD
PRINCIPAL_INVESTIGATOR
University of Southern California
Junfeng Zhang, PhD
PRINCIPAL_INVESTIGATOR
Duke University

Study Locations (Sites)

Keck School of Medicine, University of Southern California
Los Angeles, California, 90033
United States

Collaborators and Investigators

Sponsor: University of Southern California

  • Zhanghua Chen, PhD, PRINCIPAL_INVESTIGATOR, University of Southern California
  • Junfeng Zhang, PhD, PRINCIPAL_INVESTIGATOR, Duke University

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-07-11
Study Completion Date2027-06-30

Study Record Updates

Study Start Date2023-07-11
Study Completion Date2027-06-30

Terms related to this study

Keywords Provided by Researchers

  • Air pollution
  • Particulate matter
  • Air purifier
  • HEPA filter
  • Atherosclerosis
  • Ischemic Heart Disease
  • Thrombosis
  • Cardiovascular Disease

Additional Relevant MeSH Terms

  • Air Pollution
  • Atherosclerosis