Using Indoor Air Filtration to Slow Atherothrombosis Progression in Adults With Ischemic Heart Disease History

Description

This double-blind, randomized, crossover trial aims to test the hypothesis that longer-term indoor air filtration intervention can slow atherothrombosis progression by reducing indoor fine particulate matter (PM2.5) exposure in adults with ischemic heart disease history.

Conditions

Air Pollution, Atherosclerosis

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Study Overview

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Study Details

Study overview

This double-blind, randomized, crossover trial aims to test the hypothesis that longer-term indoor air filtration intervention can slow atherothrombosis progression by reducing indoor fine particulate matter (PM2.5) exposure in adults with ischemic heart disease history.

Slowing Atherothrombosis Progression Through Indoor Air Filtration: A Crossover Trial in Hispanic and Non-Hispanic Adults With Ischemic Heart Disease History

Using Indoor Air Filtration to Slow Atherothrombosis Progression in Adults With Ischemic Heart Disease History

Condition
Air Pollution
Intervention / Treatment

-

Contacts and Locations

Los Angeles

Keck School of Medicine, University of Southern California, Los Angeles, California, United States, 90033

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Age between 65 and 84 years old;
  • * Weight ≥ 110 pounds;
  • * Nonsmokers for at least 1 year;
  • * Have ischemic heart disease history, clinically stable for 6 months, without any deterioration in symptoms or episodes of angina based on past electronic medical records;
  • * Both English and Spanish speaking participants will be included in the recruitment;
  • * Live in the Los Angeles County.
  • * Have history of degenerative disease of the nervous system such as dementia and Alzheimer's;
  • * Currently have active cancer treatments;
  • * The residential house has already had HEPA filters;
  • * Participants will move out from the current residential address in the next 2 years;
  • * Participants will spend more than 1 month living outside the primary home;
  • * Have any health conditions that prohibit collecting health and covariate data and biospecimens;
  • * Participants' residential houses are not feasible for setting up air purifiers and air pollutants monitors.

Ages Eligible for Study

65 Years to 84 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Southern California,

Zhanghua Chen, PhD, PRINCIPAL_INVESTIGATOR, University of Southern California

Junfeng Zhang, PhD, PRINCIPAL_INVESTIGATOR, Duke University

Study Record Dates

2027-06-30