Ovarian Tissue Cryopreservation for Fertility Preservation

Description

The goal of this observational study is to learn about fertility preservation for pre-pubertal, peri-pubertal, and adult participants that are unable to pursue clinical standard of care fertility preservation such as egg (oocyte) and embryo cryopreservation. In addition, this study will provide research tissue for the following Specific Aims: 1. To optimize techniques for cryopreservation of ovarian tissues from patients at significant risk for infertility. 2. To investigate factors affecting successful maturation ovarian tissue. Participants will undergo a surgical procedure to remove an ovary (oophorectomy) to preserve their gonadal tissue for fertility preservation.

Conditions

Cancer, Autoimmune Diseases

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Study Overview

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Study Details

Study overview

The goal of this observational study is to learn about fertility preservation for pre-pubertal, peri-pubertal, and adult participants that are unable to pursue clinical standard of care fertility preservation such as egg (oocyte) and embryo cryopreservation. In addition, this study will provide research tissue for the following Specific Aims: 1. To optimize techniques for cryopreservation of ovarian tissues from patients at significant risk for infertility. 2. To investigate factors affecting successful maturation ovarian tissue. Participants will undergo a surgical procedure to remove an ovary (oophorectomy) to preserve their gonadal tissue for fertility preservation.

Ovarian Tissue Cryopreservation for Fertility Preservation in Patients Facing Infertility-causing Diseases or Treatment Regimens

Ovarian Tissue Cryopreservation for Fertility Preservation

Condition
Cancer
Intervention / Treatment

-

Contacts and Locations

Pittsburgh

Magee-Womens Hospital, Pittsburgh, Pennsylvania, United States, 15213

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Be female age less than 40 years old.
  • * Unable or unwilling to make use of oocyte or embryo banking alone.
  • * Be scheduled to undergo surgery, chemotherapy, drug treatment and/or radiation for the treatment or prevention of a medical condition or malignancy with risk of causing permanent and complete loss of subsequent ovarian function.
  • * Or, have a medical condition or malignancy that requires removal of all or part of one or both ovaries.
  • * Or, Have newly diagnosed or recurrent disease. Those who were not enrolled at the time of initial diagnosis (i.e., patients with recurrent disease) are eligible if they have not previously received therapy that is viewed as likely to result in complete and permanent loss of ovarian function.
  • * Have two ovaries if undergoing elective removal of an ovary for fertility preservation only.
  • * Diagnosed with psychological, psychiatric, or other conditions which prevent giving fully informed consent.
  • * Diagnosed with an underlying medical condition that significantly increases their risk of complications from anesthesia and surgery.

Ages Eligible for Study

to 39 Years

Sexes Eligible for Study

FEMALE

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Pittsburgh,

Kyle Orwig, PhD, PRINCIPAL_INVESTIGATOR, University of Pittsburgh/ University of Pittsburgh Medical Center

Study Record Dates

2031-01