A SMART Trial of Adaptive Exercises to Optimize Aerobic-Fitness Responses

Description

The goal of this clinical trial is to test 6 months of aerobic exercise in older adults who are 65 years or older and have mild cognitive impairment (MCI) or probable/possible mild Alzheimer's Disease. The main questions it aims to answer are: * test the effects of aerobic exercise on aerobic fitness, white matter hyperintensity (WMH) volume, and patient-centered outcomes; * identify the best exercise to improve aerobic fitness and reduce non-responses over 6 months; and * examines the mechanisms of aerobic exercise's action on memory in older adults with early AD. Participants will receive 6 months of supervised exercise, undergo cognitive data collection and exercise testing 5 times over a year span, have an MRI brain scan 3 times over a one-year span, and have monthly follow-up discussions on health and wellness.

Conditions

Mild Cognitive Impairment, Alzheimer Disease, Cognitive Impairment, Cognitive Decline, Memory Loss, Memory Impairment

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Study Overview

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Study Details

Study overview

The goal of this clinical trial is to test 6 months of aerobic exercise in older adults who are 65 years or older and have mild cognitive impairment (MCI) or probable/possible mild Alzheimer's Disease. The main questions it aims to answer are: * test the effects of aerobic exercise on aerobic fitness, white matter hyperintensity (WMH) volume, and patient-centered outcomes; * identify the best exercise to improve aerobic fitness and reduce non-responses over 6 months; and * examines the mechanisms of aerobic exercise's action on memory in older adults with early AD. Participants will receive 6 months of supervised exercise, undergo cognitive data collection and exercise testing 5 times over a year span, have an MRI brain scan 3 times over a one-year span, and have monthly follow-up discussions on health and wellness.

Precision Medicine in Alzheimer's Disease: A SMART Trial of Adaptive Exercises and Their Mechanisms of Action Using AT(N) Biomarkers to Optimize Aerobic-Fitness Responses (The FIT-AD SMART Trial)

A SMART Trial of Adaptive Exercises to Optimize Aerobic-Fitness Responses

Condition
Mild Cognitive Impairment
Intervention / Treatment

-

Contacts and Locations

Phoenix

Arizona State University, Phoenix, Arizona, United States, 85004

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Clinical diagnosis of MCI or probable and possible mild AD dementia according to 2011 Alzheimer's association-NIA criteria.
  • * Community-dwelling, e.g., homes and assisted living
  • * Age 65 years and older
  • * Medical clearance from PCP or cardiovascular provider
  • * Have a qualified study partner
  • * Agree to the blood draws
  • * Verified MRI safety
  • * Age 18 or older
  • * Contact with participant ≥ 2 times per week for ≥ 6 months
  • * Know the participant's memory status and ability to perform activities of daily living
  • * Consent to participant
  • * Resting HR ≤ 50 or ≥ 100 beats/min after 5-minutes of quiet resting
  • * American College of Sports Medicine contraindications to exercise
  • * New, unevaluated symptoms or diseases a healthcare provider has not evaluated
  • * Abnormal cardiac condition uncovered during VO2peak testing
  • * Enrollment in another intervention that aims at improving cognition
  • * Moderate to strenuous exercise ≥150 minutes a week in the previous 6 months
  • * ≥ 2 anti-depression medications, or poorly managed or unstable depression
  • * Poorly managed or unstable anxiety
  • * none

Ages Eligible for Study

65 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Arizona State University,

Fang Yu, PhD, PRINCIPAL_INVESTIGATOR, Arizona State University

Study Record Dates

2028-06-30