RECRUITING

Safety, Tolerability, and Preliminary Efficacy of CJRB-101 With Pembrolizumab in Subjects With Selected Types of Advanced or Metastatic Cancer

Conditions

NSCLC HNSCC Melanoma Metastatic Cancer Advanced Solid Tumor Advanced Cancer Live Biotherapeutic Product Keytruda CJRB-101 metastatic Immune checkpoint inhibitor Pembrolizumab CJB-101-01 anti-PD1 anti-PDL1

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Study CJB-101-01 will be conducted at multiple centers in the USA and Republic of Korea as an open-label safety and preliminary efficacy study of CJRB-101 in combination with pembrolizumab in subjects with selected types of advanced or metastatic cancer. The proposed study intends to address the unmet medical needs of low response rate and refractoriness to immune checkpoint inhibitors typically observed in this subject population by performing assessments of response, dose limiting toxicities, pharmacodynamic, and the effect on microbiome biomarkers at different dose levels of CJRB-101 combined with pembrolizumab.

Official Title

Phase 1/2 Open Label, Safety and Preliminary Efficacy Study of a Live Biotherapeutic Product (CJRB-101) in Combination With Pembrolizumab in Subjects With Selected Types of Advanced or Metastatic Cancer

Quick Facts

Study Start:2023-09-11

Study Completion:2027-10

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:RECRUITING

Study ID

NCT05877430

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:No

Standard Ages:ADULT, OLDER_ADULT

Inclusion Criteria	Exclusion Criteria
1. Willing and able to provide informed consent 2. ≥18 years of age at the time of signing the informed consent form 3. Pathologically documented histological or cytological evidence of NSCLC, HNSCC, or melanoma. 4. Has at least 1 measurable target lesion per RECIST v1.1 that has not been resected/biopsied/or irradiated before enrollment in the study 5. Diagnosis of locally advanced unresectable or metastatic NSCLC, HNSCC, or melanoma in subjects who are ICI treatment-naive or relapsed/refractory, including PD-1/PD-L1 inhibitors 6. ICI treatment-naive subjects must meet the following criteria: 1. NSCLC: Subjects with metastatic or with unresectable, recurrent NSCLC whose tumors must have no EGFR or ALK genomic aberrations and express PD-L1 \[TPS≥50%\] 2. HNSCC: Subjects with metastatic or with unresectable, recurrent HNSCC whose tumors express PD-L1 \[CPS ≥20\] 3. Melanoma: Irrespective of PD-L1 result and BRAF V600 mutation 4. Subjects has not received prior systemic treatment for their metastatic tumor. Subjects who received adjuvant or neoadjuvant therapy are eligible if the adjuvant/neoadjuvant therapy was completed at least 6 months before the development of metastatic disease. 7. ICI treatment-refractory subjects as defined by the following criteria: 1. Has received at least 2 cycles of anti-PD-(L)1 therapy either as monotherapy or in combination 2. Has demonstrated disease progression after ICI treatment by RECIST v1.1 3. Has received less than three lines of systemic therapy for metastatic tumor 8. ECOG performance status of 0 or 1 9. Be willing to provide archival tissue or fresh biopsy 10. Have adequate organ function 11. All Grade 3 or greater AEs resolved earlier to Grade 2 or less	1. Cancer type and genomic tumor aberrations: 1. NSCLC subjects with EGFR or ALK genomic tumor aberrations 2. HNSCC subjects with nasopharyngeal cancer 2. For ICI refractory/relapsed subjects: Immune related AEs ≥Grade 3 that led to discontinuation of prior immune-modulatory agents including PD-1/PD-L1 inhibitors 3. With uncontrolled or untreated brain metastasis or leptomeningeal disease 4. Active autoimmune disease that has required systemic treatment in the past 2 years 5. Received a fecal transplant 6. Concurrent participation in another interventional clinical study or use of another investigational agent within 30 days of study consent 7. Contraindication to IV contrast that cannot be managed with pre-medication 8. Female subjects who are pregnant or breastfeeding 9. Male subjects who are unwilling or unable to use an acceptable method of birth control to avoid pregnancy 10. Has a known inability for oral intake of capsules 11. Has received a live vaccine within 4 weeks of start of the study treatment 12. Diagnosis of prior immunodeficiency or organ transplant requiring immunosuppressive therapy 13. Has received whole blood transfusion, blood component transfusion, or colony stimulating factors within 1 week prior to the 1st dose of study treatment 14. In the judgment of the investigator, subjects unlikely to comply with study procedures, restrictions and requirements 15. Has active interstitial lung disease (ILD)/pneumonitis or a history of ILD/pneumonitis requiring treatment with systemic steroids 16. Have allergy to clindamycin, erythromycin, and ampicillin 17. Has signs and symptoms of colitis at screening 18. Infection requiring systemic antibacterial, antifungal, or antiviral therapy within 14 days before study treatment (Note: Antiviral therapy is permitted for subjects with chronic HBV or HCV infection) 19. Untreated chronic hepatitis B or chronic HBV carriers with HBV DNA\>500 IU/mL (or \>2500 copies/mL) at screening (Note: Inactive hepatitis B surface antigen (HbsAg) carriers, treated and stable hepatitis B (HBV DNA \< 500 IU/mL or \< 2500 copies/mL) can be enrolled. Subjects with detectable HbsAg or detectable HBV DNA should be managed per treatment guidelines. Subjects receiving antivirals at screening should have been treated for \> 2 weeks before study treatment.) 20. With active hepatitis C (Note: Subjects with a negative HCV antibody test at screening or positive HCV antibody test followed by a negative HCV ribonucleic acid (RNA) test at screening are eligible. The HCV RNA test will be performed only for subjects testing positive for HCV antibody. Subjects receiving antivirals at screening should have been treated for \> 2 weeks before study treatment.) 21. Known history of HIV infection 22. History of active inflammatory bowel disease with diarrhea believed to be caused by active inflammatory bowel disease in the past 12 months 23. Major surgery for any reason, except diagnostic biopsy, within 4 weeks of study informed consent and or if the subject has not fully recovered from the surgery within 4 weeks of informed consent 24. History of major gastrointestinal surgery 25. History or current evidence of any condition, therapy, or laboratory abnormality that might confound the results of the trial 26. Currently active, clinically significant cardiovascular disease 27. Known active intravenous drug or alcohol abuse or use of other drugs of abuse 28. Has any contraindication as mentioned in the recent Keytruda, Highlights of Prescribing Information (pembrolizumab)

Inclusion Criteria

Exclusion Criteria

1. Willing and able to provide informed consent
2. ≥18 years of age at the time of signing the informed consent form
3. Pathologically documented histological or cytological evidence of NSCLC, HNSCC, or melanoma.
4. Has at least 1 measurable target lesion per RECIST v1.1 that has not been resected/biopsied/or irradiated before enrollment in the study
5. Diagnosis of locally advanced unresectable or metastatic NSCLC, HNSCC, or melanoma in subjects who are ICI treatment-naive or relapsed/refractory, including PD-1/PD-L1 inhibitors
6. ICI treatment-naive subjects must meet the following criteria:
1. NSCLC: Subjects with metastatic or with unresectable, recurrent NSCLC whose tumors must have no EGFR or ALK genomic aberrations and express PD-L1 \[TPS≥50%\]
2. HNSCC: Subjects with metastatic or with unresectable, recurrent HNSCC whose tumors express PD-L1 \[CPS ≥20\]
3. Melanoma: Irrespective of PD-L1 result and BRAF V600 mutation
4. Subjects has not received prior systemic treatment for their metastatic tumor. Subjects who received adjuvant or neoadjuvant therapy are eligible if the adjuvant/neoadjuvant therapy was completed at least 6 months before the development of metastatic disease.
7. ICI treatment-refractory subjects as defined by the following criteria:
1. Has received at least 2 cycles of anti-PD-(L)1 therapy either as monotherapy or in combination
2. Has demonstrated disease progression after ICI treatment by RECIST v1.1
3. Has received less than three lines of systemic therapy for metastatic tumor
8. ECOG performance status of 0 or 1
9. Be willing to provide archival tissue or fresh biopsy
10. Have adequate organ function
11. All Grade 3 or greater AEs resolved earlier to Grade 2 or less

1. Cancer type and genomic tumor aberrations:
1. NSCLC subjects with EGFR or ALK genomic tumor aberrations
2. HNSCC subjects with nasopharyngeal cancer
2. For ICI refractory/relapsed subjects: Immune related AEs ≥Grade 3 that led to discontinuation of prior immune-modulatory agents including PD-1/PD-L1 inhibitors
3. With uncontrolled or untreated brain metastasis or leptomeningeal disease
4. Active autoimmune disease that has required systemic treatment in the past 2 years
5. Received a fecal transplant
6. Concurrent participation in another interventional clinical study or use of another investigational agent within 30 days of study consent
7. Contraindication to IV contrast that cannot be managed with pre-medication
8. Female subjects who are pregnant or breastfeeding
9. Male subjects who are unwilling or unable to use an acceptable method of birth control to avoid pregnancy
10. Has a known inability for oral intake of capsules
11. Has received a live vaccine within 4 weeks of start of the study treatment
12. Diagnosis of prior immunodeficiency or organ transplant requiring immunosuppressive therapy
13. Has received whole blood transfusion, blood component transfusion, or colony stimulating factors within 1 week prior to the 1st dose of study treatment
14. In the judgment of the investigator, subjects unlikely to comply with study procedures, restrictions and requirements
15. Has active interstitial lung disease (ILD)/pneumonitis or a history of ILD/pneumonitis requiring treatment with systemic steroids
16. Have allergy to clindamycin, erythromycin, and ampicillin
17. Has signs and symptoms of colitis at screening
18. Infection requiring systemic antibacterial, antifungal, or antiviral therapy within 14 days before study treatment (Note: Antiviral therapy is permitted for subjects with chronic HBV or HCV infection)
19. Untreated chronic hepatitis B or chronic HBV carriers with HBV DNA\>500 IU/mL (or \>2500 copies/mL) at screening (Note: Inactive hepatitis B surface antigen (HbsAg) carriers, treated and stable hepatitis B (HBV DNA \< 500 IU/mL or \< 2500 copies/mL) can be enrolled. Subjects with detectable HbsAg or detectable HBV DNA should be managed per treatment guidelines. Subjects receiving antivirals at screening should have been treated for \> 2 weeks before study treatment.)
20. With active hepatitis C (Note: Subjects with a negative HCV antibody test at screening or positive HCV antibody test followed by a negative HCV ribonucleic acid (RNA) test at screening are eligible. The HCV RNA test will be performed only for subjects testing positive for HCV antibody. Subjects receiving antivirals at screening should have been treated for \> 2 weeks before study treatment.)
21. Known history of HIV infection
22. History of active inflammatory bowel disease with diarrhea believed to be caused by active inflammatory bowel disease in the past 12 months
23. Major surgery for any reason, except diagnostic biopsy, within 4 weeks of study informed consent and or if the subject has not fully recovered from the surgery within 4 weeks of informed consent
24. History of major gastrointestinal surgery
25. History or current evidence of any condition, therapy, or laboratory abnormality that might confound the results of the trial
26. Currently active, clinically significant cardiovascular disease
27. Known active intravenous drug or alcohol abuse or use of other drugs of abuse
28. Has any contraindication as mentioned in the recent Keytruda, Highlights of Prescribing Information (pembrolizumab)

Contacts and Locations

Study Contact

Hyun Kim

CONTACT

+82-2-6078-3456

clinical.development@cj.net

Study Locations (Sites)

University of California, Irvine

Irvine, California, 92697

United States

University of Pittsburgh

Pittsburgh, Pennsylvania, 15260

United States

Collaborators and Investigators

Sponsor: CJ Bioscience, Inc.

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-09-11

Study Completion Date2027-10

Study Record Updates

Study Start Date2023-09-11

Study Completion Date2027-10

Terms related to this study

Keywords Provided by Researchers

Live Biotherapeutic Product
Keytruda
CJRB-101
metastatic
Immune checkpoint inhibitor
Pembrolizumab
CJB-101-01
anti-PD1
anti-PDL1

Additional Relevant MeSH Terms

NSCLC
HNSCC
Melanoma
Metastatic Cancer
Advanced Solid Tumor
Advanced Cancer