Accelerated rTMS for Post-Stroke Apathy

Description

This pilot study will investigate the safety, feasibility, tolerability, and preliminary efficacy of accelerated high-dose repetitive transcranial magnetic stimulation (rTMS) targeting the medial prefrontal cortex (mPFC) to address apathy symptoms in individuals with chronic stroke.

Conditions

Apathy, Stroke Sequelae, Stroke (CVA) or TIA, Stroke/Brain Attack, Motivation, Abulia

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Study Overview

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Study Details

Study overview

This pilot study will investigate the safety, feasibility, tolerability, and preliminary efficacy of accelerated high-dose repetitive transcranial magnetic stimulation (rTMS) targeting the medial prefrontal cortex (mPFC) to address apathy symptoms in individuals with chronic stroke.

Accelerated rTMS for Post-Stroke Apathy: Targeting Amotivation Toward Improving Whole Health and Rehabilitation Engagement

Accelerated rTMS for Post-Stroke Apathy

Condition
Apathy
Intervention / Treatment

-

Contacts and Locations

Charleston

Medical University of South Carolina Brain Stimulation Lab, Charleston, South Carolina, United States, 29403

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. 40 years old or greater
  • 2. Right- or left-hemisphere ischemic or hemorrhagic stroke with at least 6 months chronicity
  • 3. Symptomatic apathy as confirmed by (A) total score on the Apathy Evaluation Scale (AES) of ≥39 as rated by the participant or caregiver informant
  • 4. Intact cortex under the coil at the stimulation target site confirmed by neuroimaging
  • 5. Ability to participate in psychometric testing and cognitive tasks
  • 1. Primary extra-axial hemorrhage (subdural or subarachnoid) without ischemic stroke or intraparenchymal hemorrhage
  • 2. Concomitant neurological disorders affecting motor or cognitive function (e.g. dementia)
  • 3. Moderate or severe global aphasia
  • 4. Visual impairment precluding completion of cognitive tasks
  • 5. Presence of contraindications to MRI or TMS including electrically, magnetically or mechanically activated metal or nonmetal implants such as cardiac pacemakers, intracerebral vascular clips, or any other electrically sensitive support system;
  • 6. Pregnancy (to be later confirmed by UPT in any premenopausal female participants)
  • 7. History of a seizure disorder
  • 8. Preexisting scalp lesion, wound, bone defect, or hemicraniectomy
  • 9. Claustrophobia precluding the ability to undergo an MRI
  • 10. Active substance use disorder
  • 11. Psychotic disorders
  • 12. Bipolar 1 Disorder
  • 13. Acute suicidality as assessed by the Columbia Suicide Severity Rating Scale (C-SSRS) or suicide attempt in the previous year

Ages Eligible for Study

40 Years to

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Medical University of South Carolina,

Parneet Grewal, MD, PRINCIPAL_INVESTIGATOR, Medical University of South Carolina

Study Record Dates

2025-05-30