Impact of Yo-Yo Sleep on Cardiometabolic Health

Description

The goal of this clinical trial is to test the impact of repeated intermittent short sleep, with short sleep maintained 5 days per week followed by 2 days of prolonged sleep, compared to daily adequate sleep, on energy balance and cardiometabolic risk. A secondary goal of this research is to determine if maintaining a constant midpoint of sleep while undergoing intermittent short sleep, leads to better outcomes than intermittent short sleep with a 2-hour delay in sleep midpoint. The aims of this research will be tested in the context of a 3-group, parallel-arm, outpatient intervention of 4 weeks in duration, in young-to-middle-aged adults (aged 18-49 years).

Conditions

Cardiometabolic Syndrome, Obesity

Study Overview

Study Details

Study overview

The goal of this clinical trial is to test the impact of repeated intermittent short sleep, with short sleep maintained 5 days per week followed by 2 days of prolonged sleep, compared to daily adequate sleep, on energy balance and cardiometabolic risk. A secondary goal of this research is to determine if maintaining a constant midpoint of sleep while undergoing intermittent short sleep, leads to better outcomes than intermittent short sleep with a 2-hour delay in sleep midpoint. The aims of this research will be tested in the context of a 3-group, parallel-arm, outpatient intervention of 4 weeks in duration, in young-to-middle-aged adults (aged 18-49 years).

Impact of Yo-Yo Sleep on Cardiometabolic Health

Impact of Yo-Yo Sleep on Cardiometabolic Health

Condition
Cardiometabolic Syndrome
Intervention / Treatment

-

Contacts and Locations

New York

Columbia University Irving Medical Center, New York, New York, United States, 10032

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Aged 18 to 49 years
  • * BMI 20-29.9 kg/m2
  • * Habitually sleeping 7-9 hours/night without sleep aids or naps
  • * Sleep disorders
  • * Psychiatric disorders (including eating disorders) and seasonal affective disorder
  • * Pregnancy (current/prior year)
  • * Breastfeeding
  • * Smokers (Any cigarette smoking or ex-smokers \<3years)
  • * Diabetes
  • * Elevated blood pressure, taking beta-blockers
  • * Individuals taking anti-coagulants or anti-platelets
  • * Recent weight change or participation in a weight loss program or have ever had bariatric surgery or other weight loss or gastrointestinal procedure.
  • * Travel across time zones; shift work (non-traditional hours)

Ages Eligible for Study

18 Years to 49 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

Yes

Collaborators and Investigators

Columbia University,

Marie-Pierre St-Onge, PhD, PRINCIPAL_INVESTIGATOR, Columbia University

Study Record Dates

2028-06