Vibrotactile Coordinated Reset: a Non-invasive Treatment for Parkinson's Disease 2

Eligibility Criteria

• 1. Between the ages of 45-85
• 2. Diagnosis of idiopathic Parkinson's disease from movement disorders neurologist with the United Kingdom Brain Bank criteria of bradykinesia and one or more of the following: rest tremor, rigidity, and balance problems not from visual, vestibular, cerebellar, or proprioceptive conditions
• 3. Bilateral, moderate-stage impairment, as defined as Hoehn \& Yahr Stages II-IV in the on-medication state
• 4. Able to walk and stand unassisted
• 5. Participants must be on a stable regimen of PD medication (at least 4 weeks prior to enrollment)
• 6. Responsive to levodopa (self-reported)
• 7. Willing to keep exercise and medication regimen as stable as possible for the duration of the study
• 8. Able to provide informed consent
• 9. Independently, or with social support, able to use technology and access virtual meeting if needed to troubleshoot technology
• 10. Participants must speak English and can communicate with staff
• 11. Patients live close to or in the area of where the clinic is located and are able to travel to the clinic for all screening and assessment appointments.
• 1. Severe depression or suicide ideation (as assessed with Beck Depression Inventory (BDI), BDI \<28, and Columbia Suicide Severity Rating scale (SSRS), C-SSRS \< 4)
• 2. Presence of other neurological or musculoskeletal disorders as determined by the physician during screening.
• 3. Participation in another drug, device, biologic, or intervention trial concurrently or within the preceding 2-month
• 4. Physical limitations unrelated to Parkinson's disease
• 5. Recent change or addition of psychoactive medications for non-parkinsonian treatments
• 6. Any kind of brain surgery or neurostimulators
• 7. Pregnancy, breastfeeding, or lack of reliable contraception in women of childbearing age