Allopurinol Improves Heart Function in African Americans With Resistant Hypertension

Description

African American adults in the United States have the highest prevalence rate of high blood pressure (hypertension) and heart failure in the world. African Americans with treatment resistant hypertension have higher levels of the enzyme - xanthine oxidase compared to Caucasians. This trial will test if administration of the xanthine oxidase inhibitor - Allopurinol (commonly used in the treatment of gout), given over a period of 8 weeks, will improve heart function, exercise ability and quality of life in African American Veterans with resistant hypertension.

Conditions

Heart Failure Preserved Ejection Fraction, Resistant Hypertension

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Study Overview

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Study Details

Study overview

African American adults in the United States have the highest prevalence rate of high blood pressure (hypertension) and heart failure in the world. African Americans with treatment resistant hypertension have higher levels of the enzyme - xanthine oxidase compared to Caucasians. This trial will test if administration of the xanthine oxidase inhibitor - Allopurinol (commonly used in the treatment of gout), given over a period of 8 weeks, will improve heart function, exercise ability and quality of life in African American Veterans with resistant hypertension.

Allopurinol Improves Diastolic Function in African Americans With Resistant Hypertension

Allopurinol Improves Heart Function in African Americans With Resistant Hypertension

Condition
Heart Failure Preserved Ejection Fraction
Intervention / Treatment

-

Contacts and Locations

Birmingham

Birmingham VA Medical Center, Birmingham, AL, Birmingham, Alabama, United States, 35233-1927

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Veteran
  • 2. African American
  • 3. Resistant hypertension diagnosis (defined as blood pressure greater than 140/90 mmHg at 2 clinic visits despite the use of 3 antihypertensive medications at pharmacologically effective doses)
  • 4. Locale - Birmingham, AL and surrounding areas
  • 1. History of heart failure
  • 2. Chronic kidney disease (estimated creatinine clearance \< 60 ml/min)
  • 3. Chronic steroid therapy
  • 4. Known coronary artery disease
  • 5. Known causes of secondary hypertension
  • 6. Already taking Allopurinol
  • 1. Claustrophobia
  • 2. Cardiac implantable electronic device (permanent pacemaker and/or intracardiac defibrillator)
  • 3. Metal clips and/devices or other item that specifically prohibit safe CMR

Ages Eligible for Study

18 Years to 75 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

VA Office of Research and Development,

Louis J Dellitalia, MD, PRINCIPAL_INVESTIGATOR, Birmingham VA Medical Center, Birmingham, AL

Study Record Dates

2026-05-31