RECRUITING

Improving Cognition Through Telehealth Aerobic Exercise and Cognitive Training After a First Schizophrenia Episode

Conditions

Schizophrenia Schizophreniform Disorder Schizoaffective Disorder First-Episode Schizophrenia Cognitive Remediation Physical Exercise Brain Derived Neurotrophic Factor Telehealth Intervention Moderated Online Social Therapy (MOST)Motivational Text Messaging Program (Chorus)

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

The participants in the study will receive psychiatric treatment at the UCLA Aftercare Research Program. All participants in this 12-month RCT will receive cognitive training. Half of the patients will also be randomly assigned to the aerobic exercise and strength training condition, and the other half will be randomly assigned to the Healthy Living Group condition. The primary outcome measures are improvement in cognition and level of engagement in the in-group and at-home exercise sessions. Increases in the level of the patient's serum brain-derived neurotropic factor (specifically Mature BDNF) which causes greater brain neuroplasticity and is indicator of engagement in aerobic exercise, will be measured early in the treatment phase in order to confirm engagement of this target. In order to demonstrate the feasibility and portability of this intervention outside of academic research programs, the interventions will be provided via videoconferencing. The proposed study will incorporate additional methods to maximize participation in the exercise condition, including the use of the Moderated Online Social Therapy (MOST) platform to enhance motivation for treatment based on Self-Determination Theory principles, and a "bridging" group to help the participants generalize gains to everyday functioning. In addition, the exercise group participants will receive personally tailored text reminders to exercise.

Official Title

Improving Cognition Through Telehealth Aerobic Exercise and Cognitive Training After a First Schizophrenia Episode

Quick Facts

Study Start:2023-05-23

Study Completion:2028-05-31

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:RECRUITING

Study ID

NCT05890183

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years to 45 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:No

Standard Ages:ADULT

Inclusion Criteria	Exclusion Criteria
1. a first episode of a psychotic illness that began within the past two years; 2. a diagnosis by DSM-5 of schizophrenia, schizoaffective disorder, or schizophreniform disorder; 3. age 18 to 45 years of age; 4. sufficient acculturation and fluency in the English language to avoid invalidating research measures; and 5. residence likely to be within commuting distance of the UCLA Aftercare Research Program.	1. premorbid IQ less than 70; 2. evidence of a known neurological disorder (e.g., epilepsy) or significant head injury; 3. evidence of moderate or severe substance use disorder within the six months prior to the first episode or evidence of a substance-induced psychosis.

Inclusion Criteria

Exclusion Criteria

1. a first episode of a psychotic illness that began within the past two years;
2. a diagnosis by DSM-5 of schizophrenia, schizoaffective disorder, or schizophreniform disorder;
3. age 18 to 45 years of age;
4. sufficient acculturation and fluency in the English language to avoid invalidating research measures; and
5. residence likely to be within commuting distance of the UCLA Aftercare Research Program.

1. premorbid IQ less than 70;
2. evidence of a known neurological disorder (e.g., epilepsy) or significant head injury;
3. evidence of moderate or severe substance use disorder within the six months prior to the first episode or evidence of a substance-induced psychosis.

Contacts and Locations

Study Contact

Rebecca Zornitsky, MSc

CONTACT

(424) 225-1779

RZornitsky@mednet.ucla.edu

Joseph Ventura, PhD

CONTACT

(310) 206-3142

JVentura@mednet.ucla.edu

Principal Investigator

Keith H Nuechterlein, PhD

PRINCIPAL_INVESTIGATOR

University of California, Los Angeles

Study Locations (Sites)

UCLA Aftercare Research Program

Los Angeles, California, 90095-6968

United States

Collaborators and Investigators

Sponsor: University of California, Los Angeles

Keith H Nuechterlein, PhD, PRINCIPAL_INVESTIGATOR, University of California, Los Angeles

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-05-23

Study Completion Date2028-05-31

Study Record Updates

Study Start Date2023-05-23

Study Completion Date2028-05-31

Terms related to this study

Keywords Provided by Researchers

First-Episode Schizophrenia
Cognitive Remediation
Physical Exercise
Brain Derived Neurotrophic Factor
Telehealth Intervention
Moderated Online Social Therapy (MOST)
Motivational Text Messaging Program (Chorus)

Additional Relevant MeSH Terms

Schizophrenia
Schizophreniform Disorder
Schizoaffective Disorder