RECRUITING

Immune Function and the Progression to T1D

Conditions

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

To elucidate the mechanisms by which type 1 diabetes-associated genes; IFIH1, TYK2, IKZF4, as well as total genetic risk, impart functional immunoregulatory abnormalities that result in expansion of self-reactive adaptive immune cells, defective regulatory/effector mechanisms in T cells, inflammatory antigen presenting cells, and abnormal immune function in T cells and B cells.

Official Title

Immune Function and the Progression to Type 1 Diabetes:

Quick Facts

Study Start:2005-01-01
Study Completion:2085-01-01
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05899439

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:0 Years to 100 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Yes
Standard Ages:CHILD, ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. Age 18 years or older
  2. Willing and able to provide informed consent
  3. Able to understand and follow study procedures
  4. Stable medical condition
  1. Pregnancy or breastfeeding
  2. Severe psychiatric disorders
  3. Active substance abuse
  4. Unstable medical conditions
  5. Inability to comply with study requirements

Contacts and Locations

Study Contact

Jennifer L Hosford, MPH
CONTACT
352-294-5759
jennifer.hosford@peds.ufl.edu
Kieran McGrail
CONTACT
(352) 273-9299
mcgrail@pathology.ufl.edu

Study Locations (Sites)

Kieran McGrail
Gainesville, Florida, 32610
United States
The Ohio State University
Columbus, Ohio, 43210
United States
Baylor College of Medicine, Center for Research Advancement - Texas Children's Hospital
Houston, Texas, 77030
United States

Collaborators and Investigators

Sponsor: University of Florida

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2005-01-01
Study Completion Date2085-01-01

Study Record Updates

Study Start Date2005-01-01
Study Completion Date2085-01-01

Terms related to this study

Additional Relevant MeSH Terms

  • Type 1 Diabetes