To elucidate the mechanisms by which type 1 diabetes-associated genes; IFIH1, TYK2, IKZF4, as well as total genetic risk, impart functional immunoregulatory abnormalities that result in expansion of self-reactive adaptive immune cells, defective regulatory/effector mechanisms in T cells, inflammatory antigen presenting cells, and abnormal immune function in T cells and B cells.
Type 1 Diabetes
To elucidate the mechanisms by which type 1 diabetes-associated genes; IFIH1, TYK2, IKZF4, as well as total genetic risk, impart functional immunoregulatory abnormalities that result in expansion of self-reactive adaptive immune cells, defective regulatory/effector mechanisms in T cells, inflammatory antigen presenting cells, and abnormal immune function in T cells and B cells.
Immune Function and the Progression to T1D
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Kieran McGrail, Gainesville, Florida, United States, 32610
The Ohio State University, Columbus, Ohio, United States, 43210
Baylor College of Medicine, Center for Research Advancement - Texas Children's Hospital, Houston, Texas, United States, 77030
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0 Years to 100 Years
ALL
Yes
University of Florida,
2085-01-01