Improvement of Reproductive Function in Men With Spinal Cord Injury (SCI)

Description

This is a study of infertility which often occurs in men with spinal cord injury. Most men with spinal cord injury have a normal sperm count but abnormally low sperm motility - which means that the sperm does not swim well. This study will determine if a medicine given by mouth will improve sperm motility in men with spinal cord injuries. The medicine is called probenecid.

Conditions

Infertility, Male

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Study Overview

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Study Details

Study overview

This is a study of infertility which often occurs in men with spinal cord injury. Most men with spinal cord injury have a normal sperm count but abnormally low sperm motility - which means that the sperm does not swim well. This study will determine if a medicine given by mouth will improve sperm motility in men with spinal cord injuries. The medicine is called probenecid.

Improvement of Reproductive Function in Men With Spinal Cord Injury (SCI)

Improvement of Reproductive Function in Men With Spinal Cord Injury (SCI)

Condition
Infertility, Male
Intervention / Treatment

-

Contacts and Locations

Miami

University of Miami, Miami, Florida, United States, 33136

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • 1. Subject has a traumatic spinal cord injury.
  • 2. Subject is male and is 18 years or older.
  • 1. Subject has been injured less than 1 year.
  • 2. The subject is known to be azoospermic.
  • 3. The subject has an indwelling urethral Foley catheter.
  • 4. Subject is under the age of 18 years.
  • 5. Subject has an unstable medical condition including, but not limited to, Crohn's disease, ulcerative colitis, colon cancer or has other conditions deemed to be exclusionary per the Investigator.
  • 6. Subject is unable to consent or comprehend the procedures and their implications.
  • 7. Subject has a permanent implanted electrical device, i.e., cardiac pacemaker, phrenic nerve stimulator, spinal cord stimulator, etc.
  • 8. Any subject for whom the procedure or medication is otherwise contraindicated.
  • 9. Subject has hypersensitivity to probenecid.
  • 10. Subject has a history of uric acid kidney stones and/or peptic ulcer.
  • 11. The subject has had a febrile Urinary Tract Infection (UTI) within the 2 months prior to enrollment.
  • 12. The subject is taking methotrexate, aspirin, other salicylates, or anti-inflammatory medicines.
  • 13. The subject has a history of Glucose-6-phosphate dehydrogenase (G6PD) deficiency.

Ages Eligible for Study

18 Years to

Sexes Eligible for Study

MALE

Accepts Healthy Volunteers

No

Collaborators and Investigators

University of Miami,

Emad Ibrahim, MD, PRINCIPAL_INVESTIGATOR, University of Miami

Study Record Dates

2028-12-31