COMPLETED

The Impact of Exercise on Subthalamic Nucleus Neural Activity in Parkinson's Disease

Conditions

Parkinson Disease Deep Brain Stimulation

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Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Fifteen PwPD who have undergone DBS surgery and utilize the Percept system will complete a FE and VE exercise session on a stationary cycle while Off antiparkinsonian medication. Bilateral neural activity of the STN will be continuously recorded for 130 minutes (pre-, during FE or VE and post-exercise). The Movement Disorders Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) III Motor Exam and upper extremity force-tracking task will be used to determine motor response to exercise.

Official Title

The Impact of Exercise on Subthalamic Nucleus Neural Activity in Parkinson's Disease

Quick Facts

Study Start:2023-08-15

Study Completion:2024-09-20

Study Type:Not specified

Phase:Not Applicable

Enrollment:Not specified

Status:COMPLETED

Study ID

NCT05905302

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:18 Years

Sexes Eligible for Study:ALL

Accepts Healthy Volunteers:No

Standard Ages:ADULT, OLDER_ADULT

Inclusion Criteria	Exclusion Criteria
1. Adult with a diagnosis of PD by a movement disorders neurologist 2. Previous placement, at least six months, of bilateral Medtronic Precept DBS as standard of care treatment for their PD. 3. Stable and clinically optimized DBS parameters for three months prior to enrollment. 4. Demonstrate the ability to safely mount and dismount a recumbent exercise cycle with an upright back. 5. Willingness to withhold antiparkinsonian medication and DBS stimulation. 6. Exercise clearance using the American College of Sports Medicine (ACSM) Pre-participation Health Screen: a. If the ACSM screen recommends medical clearance, the subject must obtain medical clearance by their health care provider prior to participation; b. Those who choose not to obtain physician clearance will not be eligible for participation.	1. Diagnosis of dementia or any neurocognitive impairment that compromises the ability to provide informed consent. 2. A musculoskeletal issue that limits one's ability to cycle 3. Neurological disease other than Parkinson's disease (i.e. multiple sclerosis, stroke) that impacts motor or cognitive function 4. Uncontrolled cardiovascular risk factor such as a current cardiac arrhythmia, uncontrolled hypertension, untreated deep vein thrombosis, etc.

Inclusion Criteria

Exclusion Criteria

1. Adult with a diagnosis of PD by a movement disorders neurologist
2. Previous placement, at least six months, of bilateral Medtronic Precept DBS as standard of care treatment for their PD.
3. Stable and clinically optimized DBS parameters for three months prior to enrollment.
4. Demonstrate the ability to safely mount and dismount a recumbent exercise cycle with an upright back.
5. Willingness to withhold antiparkinsonian medication and DBS stimulation.
6. Exercise clearance using the American College of Sports Medicine (ACSM) Pre-participation Health Screen: a. If the ACSM screen recommends medical clearance, the subject must obtain medical clearance by their health care provider prior to participation; b. Those who choose not to obtain physician clearance will not be eligible for participation.

1. Diagnosis of dementia or any neurocognitive impairment that compromises the ability to provide informed consent.
2. A musculoskeletal issue that limits one's ability to cycle
3. Neurological disease other than Parkinson's disease (i.e. multiple sclerosis, stroke) that impacts motor or cognitive function
4. Uncontrolled cardiovascular risk factor such as a current cardiac arrhythmia, uncontrolled hypertension, untreated deep vein thrombosis, etc.

Contacts and Locations

Principal Investigator

Jay Alberts, PhD

PRINCIPAL_INVESTIGATOR

Staff

Study Locations (Sites)

Cleveland Clinic

Cleveland, Ohio, 44195

United States

Collaborators and Investigators

Sponsor: Jay Alberts

Jay Alberts, PhD, PRINCIPAL_INVESTIGATOR, Staff

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-08-15

Study Completion Date2024-09-20

Study Record Updates

Study Start Date2023-08-15

Study Completion Date2024-09-20

Terms related to this study

Additional Relevant MeSH Terms

Parkinson Disease
Deep Brain Stimulation