RECRUITING

Disruptions of Brain Networks and Sleep by Electroconvulsive Therapy

Study Overview

This clinical trial focuses on testing the efficacy of different digital interventions to promote re-engagement in cancer-related long-term follow-up care for adolescent and young adult (AYA) survivors of childhood cancer.

Description

Electroconvulsive therapy (ECT) alleviates treatment-resistant depression (TRD) through repeated generalized seizures. The goal of this study is to evaluate how ECT impacts sleep-wake regulation and efficiency of information transfer in functional networks in different states of arousal.

Official Title

Disruptions of Brain Networks and Sleep by Electroconvulsive Therapy

Quick Facts

Study Start:2023-03-07
Study Completion:2027-07-31
Study Type:Not specified
Phase:Not Applicable
Enrollment:Not specified
Status:RECRUITING

Study ID

NCT05905705

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Ages Eligible for Study:21 Years to 65 Years
Sexes Eligible for Study:ALL
Accepts Healthy Volunteers:Not specified
Standard Ages:ADULT, OLDER_ADULT
Inclusion CriteriaExclusion Criteria
  1. * Referral for initial ECT index course for Treatment-Resistant Depression (TRD), unipolar major depressive disorder or bipolar depression. Historic failure of response or remission to at least two antidepressant medications of sufficient dose and duration will be used for TRD diagnostic.
  1. * Diagnoses of schizophrenia or schizoaffective disorders.
  2. * Subjects who are unable to tolerate the Dreem device for sleep recordings will be excluded from the study.

Contacts and Locations

Study Contact

Robby Greenspan
CONTACT
314-273-6129
greenspan@wustl.edu
MohammadMehdi Kafashan
CONTACT
314-273-8848
kafashan@wustl.edu

Principal Investigator

MohammadMehdi Kafashan
PRINCIPAL_INVESTIGATOR
Washington University School of Medicine in St. Louis

Study Locations (Sites)

Washington University School of Medicine/Barnes-Jewish Hospital
Saint Louis, Missouri, 63110
United States

Collaborators and Investigators

Sponsor: Washington University School of Medicine

  • MohammadMehdi Kafashan, PRINCIPAL_INVESTIGATOR, Washington University School of Medicine in St. Louis

Study Record Dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Registration Dates

Study Start Date2023-03-07
Study Completion Date2027-07-31

Study Record Updates

Study Start Date2023-03-07
Study Completion Date2027-07-31

Terms related to this study

Additional Relevant MeSH Terms

  • Treatment Resistant Depression