Disruptions of Brain Networks and Sleep by Electroconvulsive Therapy

Description

Electroconvulsive therapy (ECT) alleviates treatment-resistant depression (TRD) through repeated generalized seizures. The goal of this study is to evaluate how ECT impacts sleep-wake regulation and efficiency of information transfer in functional networks in different states of arousal.

Conditions

Treatment Resistant Depression

Talk to us

Study Overview

On this page

Study Details

Study overview

Electroconvulsive therapy (ECT) alleviates treatment-resistant depression (TRD) through repeated generalized seizures. The goal of this study is to evaluate how ECT impacts sleep-wake regulation and efficiency of information transfer in functional networks in different states of arousal.

Disruptions of Brain Networks and Sleep by Electroconvulsive Therapy

Disruptions of Brain Networks and Sleep by Electroconvulsive Therapy

Condition
Treatment Resistant Depression
Intervention / Treatment

-

Contacts and Locations

Saint Louis

Washington University School of Medicine/Barnes-Jewish Hospital, Saint Louis, Missouri, United States, 63110

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

For general information about clinical research, read Learn About Studies.

Eligibility Criteria

  • * Referral for initial ECT index course for Treatment-Resistant Depression (TRD), unipolar major depressive disorder or bipolar depression. Historic failure of response or remission to at least two antidepressant medications of sufficient dose and duration will be used for TRD diagnostic.
  • * Diagnoses of schizophrenia or schizoaffective disorders.
  • * Subjects who are unable to tolerate the Dreem device for sleep recordings will be excluded from the study.

Ages Eligible for Study

21 Years to 65 Years

Sexes Eligible for Study

ALL

Accepts Healthy Volunteers

No

Collaborators and Investigators

Washington University School of Medicine,

MohammadMehdi Kafashan, PRINCIPAL_INVESTIGATOR, Washington University School of Medicine in St. Louis

Study Record Dates

2027-07-31